Hepatic S1P deficiency lowers plasma cholesterol levels in apoB-containing lipoproteins when LDLR function is compromised

Table 3 SREBP1 and SREBP 2 gene expression in livers of mice with SREBP1c-N overexpression

Parameter	S1P^f/fLuci	S1P^f/fCre	S1P^f/fCre + N-SREBP1c
Number and sex	4 males	4 males	4 males
SREBP1c mRNA %^#	100 ± 14	43 ± 9	392 ± 42*
SREBP2 mRNA %^#	100 ± 27	50 ± 5.3	88 ± 13*

Hepatic mRNA levels of SREBP1c and SREBP2 in the experiment presented in Fig. 6e. Each value represents the mean ± the SD of 4 mice. The statistical significance (Student’s t test) between S1P^f/fCre and S1P^f/fCre + N-SREBP1c was calculated. *P < 0.05 ^#mRNA expression is expressed as a % of the corresponding S1P^f/f Luci value

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