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Table 3 SREBP1 and SREBP 2 gene expression in livers of mice with SREBP1c-N overexpression

From: Hepatic S1P deficiency lowers plasma cholesterol levels in apoB-containing lipoproteins when LDLR function is compromised

Parameter S1Pf/fLuci S1Pf/fCre S1Pf/fCre + N-SREBP1c
Number and sex 4 males 4 males 4 males
SREBP1c mRNA %# 100 ± 14 43 ± 9 392 ± 42*
SREBP2 mRNA %# 100 ± 27 50 ± 5.3 88 ± 13*
  1. Hepatic mRNA levels of SREBP1c and SREBP2 in the experiment presented in Fig. 6e. Each value represents the mean ± the SD of 4 mice. The statistical significance (Student’s t test) between S1Pf/fCre and S1Pf/fCre + N-SREBP1c was calculated. *P < 0.05 #mRNA expression is expressed as a % of the corresponding S1Pf/f Luci value