Fig. 1
From: Review: Miglitol has potential as a therapeutic drug against obesity
Orally administered miglitol enters the circulation where it directly enhances the β3-aderenergic signaling of brown adipose tissue (BAT). Based on Sugimoto et al. [15], Sasaki et al. [18] and Sell et al. [24]. βAR: beta adrenergic signaling; AC: adenylyl cyclase; cAMP: cyclic adenosine 3′,5′-monophosphate; PKA: protein kinase A; p38αMAPK: p38 α-mitogen-activated protein kinase; PGC1α: peroxisome proliferator-activated receptor gamma coactivator 1α; PPAR: peroxisome proliferator-activated receptor; RXR: retinoid X receptor; PPRE: PPAR response element; CREB: cAMP response element binding protein; CRE: cAMP response element; HSL: hormone-sensitive lipase; UCP1: uncoupling protein 1; LPL: lipoprotein lipase; TG: triglyceride; FFA: free fatty acids