Compared to casein, bovine lactoferrin reduces plasma leptin and corticosterone and affects hypothalamic gene expression without altering weight gain or fat mass in high fat diet fed C57/BL6J mice

Table 1 Metabolic parameter assessments over 24 h for mice fed for 13 weeks with either a 10 % kJ low fat diet with 20 % casein (LFD), 40 % kJ fat diet with 20 % casein (HFD), or 40 % kJ fat diet 20 % lactoferrin (Lac)

	LFD	HFD	Lac
Energy Intake (kJ)	35.37 ± 2.94	41.11 ± 3.91	50.18 ± 5.25
VO₂ (ml/min)	1.81 ± 0.03	1.78 ± 0.03	1.71 ± 0.03
Locomotor Activity (Beam breaks)	229.79 ± 9.75	200.12 ± 12.47	196.35 ± 18.90
RER	0.82 ± 0.02^a	0.75 ± 0.01^b	0.76 ± 0.01^b
Insulin (pmol/L)	5.62 ± 0.10	6.74 ± 0.26	6.61 ± 0.59
Glucose (mmol/L)	10.00 ± 0.62	12.01 ± 1.09	11.01 ± 0.99
QUICKI	0.46 ± 0.01	0.44 ± 0.01	0.45 ± 0.00
FFA (nmol/mL)	0.19 ± 0.04	0.46 ± 0.04	0.36 ± 0.07
SAT mass (g)	0.30 ± 0.02	0.95 ± 0.12	0.77 ± 0.10
EAT mass (g)	0.83 ± 0.10	1.65 ± 0.14	1.79 ± 0.26

All data is represented as mean ± SEM (N = 8). Dissimilar letters represent significance (P < 0.05)

ISSN: 1743-7075