TY - JOUR AU - Cronise, R. J. AU - Sinclair, D. A. AU - Bremer, A. A. PY - 2014 DA - 2014// TI - The “metabolic winter” hypothesis: a cause of the current epidemics of obesity and cardiometabolic disease JO - Metab Syndr Relat Disord VL - 12 UR - https://doi.org/10.1089/met.2014.0027 DO - 10.1089/met.2014.0027 ID - Cronise2014 ER - TY - JOUR AU - Fock, K. M. AU - Khoo, J. PY - 2013 DA - 2013// TI - Diet and exercise in management of obesity and overweight JO - J Gastroenterol Hepatol VL - 28 UR - https://doi.org/10.1111/jgh.12407 DO - 10.1111/jgh.12407 ID - Fock2013 ER - TY - JOUR AU - O’Neill, S. AU - O’Driscoll, L. PY - 2015 DA - 2015// TI - Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies JO - Obes Rev VL - 16 UR - https://doi.org/10.1111/obr.12229 DO - 10.1111/obr.12229 ID - O’Neill2015 ER - TY - JOUR AU - Herpen, N. A. AU - Schrauwen-Hinderling, V. B. PY - 2008 DA - 2008// TI - Lipid accumulation in non-adipose tissue and lipotoxicity JO - Physiol Behav VL - 94 UR - https://doi.org/10.1016/j.physbeh.2007.11.049 DO - 10.1016/j.physbeh.2007.11.049 ID - Herpen2008 ER - TY - JOUR AU - Krahmer, N. AU - Farese, R. V. AU - Walther, T. C. PY - 2013 DA - 2013// TI - Balancing the fat: lipid droplets and human disease JO - EMBO Mol Med VL - 5 UR - https://doi.org/10.1002/emmm.201100671 DO - 10.1002/emmm.201100671 ID - Krahmer2013 ER - TY - JOUR AU - Angulo, P. PY - 2002 DA - 2002// TI - Nonalcoholic fatty liver disease JO - N Engl J Med VL - 346 UR - https://doi.org/10.1056/NEJMra011775 DO - 10.1056/NEJMra011775 ID - Angulo2002 ER - TY - JOUR AU - Berlanga, A. AU - Guiu-Jurado, E. AU - Porras, J. A. AU - Auguet, T. PY - 2014 DA - 2014// TI - Molecular pathways in non-alcoholic fatty liver disease JO - Clin Exp Gastroenterol VL - 7 ID - Berlanga2014 ER - TY - JOUR AU - Cohen, J. C. AU - Horton, J. D. AU - Hobbs, H. H. PY - 2011 DA - 2011// TI - Human fatty liver disease: old questions and new insights JO - Science VL - 332 UR - https://doi.org/10.1126/science.1204265 DO - 10.1126/science.1204265 ID - Cohen2011 ER - TY - JOUR AU - Bradbury, M. W. AU - Berk, P. D. PY - 2004 DA - 2004// TI - Lipid metabolism in hepatic steatosis JO - Clin Liver Dis VL - 8 UR - https://doi.org/10.1016/j.cld.2004.04.005 DO - 10.1016/j.cld.2004.04.005 ID - Bradbury2004 ER - TY - JOUR AU - Gruben, N. AU - Shiri-Sverdlov, R. AU - Koonen, D. P. AU - Hofker, M. H. PY - 1842 DA - 1842// TI - Nonalcoholic fatty liver disease: A main driver of insulin resistance or a dangerous liaison? JO - Biochim Biophys Acta VL - 2014 ID - Gruben1842 ER - TY - JOUR AU - Casas-Agustench, P. AU - Lopez-Uriarte, P. AU - Bullo, M. AU - Ros, E. AU - Gomez-Flores, A. AU - Salas-Salvado, J. PY - 2009 DA - 2009// TI - Acute effects of three high-fat meals with different fat saturations on energy expenditure, substrate oxidation and satiety JO - Clin Nutr VL - 28 UR - https://doi.org/10.1016/j.clnu.2008.10.008 DO - 10.1016/j.clnu.2008.10.008 ID - Casas-Agustench2009 ER - TY - JOUR AU - Buettner, R. AU - Parhofer, K. G. AU - Woenckhaus, M. AU - Wrede, C. E. AU - Kunz-Schughart, L. A. AU - Scholmerich, J. PY - 2006 DA - 2006// TI - Defining high-fat-diet rat models: metabolic and molecular effects of different fat types JO - J Mol Endocrinol VL - 36 UR - https://doi.org/10.1677/jme.1.01909 DO - 10.1677/jme.1.01909 ID - Buettner2006 ER - TY - JOUR AU - Jen, K. L. AU - Buison, A. AU - Pellizzon, M. AU - Ordiz, F. AU - Santa Ana, L. AU - Brown, J. PY - 2003 DA - 2003// TI - Differential effects of fatty acids and exercise on body weight regulation and metabolism in female Wistar rats JO - Exp Biol Med (Maywood) VL - 228 ID - Jen2003 ER - TY - JOUR AU - Kremmyda, L. S. AU - Tvrzicka, E. AU - Stankova, B. AU - Zak, A. PY - 2011 DA - 2011// TI - Fatty acids as biocompounds: their role in human metabolism, health and disease: a review. part 2: fatty acid physiological roles and applications in human health and disease JO - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub VL - 155 UR - https://doi.org/10.5507/bp.2011.052 DO - 10.5507/bp.2011.052 ID - Kremmyda2011 ER - TY - JOUR AU - Suburu, J. AU - Gu, Z. AU - Chen, H. AU - Chen, W. AU - Zhang, H. AU - Chen, Y. Q. PY - 2013 DA - 2013// TI - Fatty acid metabolism: Implications for diet, genetic variation, and disease JO - Food Biosci VL - 4 UR - https://doi.org/10.1016/j.fbio.2013.07.003 DO - 10.1016/j.fbio.2013.07.003 ID - Suburu2013 ER - TY - JOUR AU - Austin, G. L. AU - Ogden, L. G. AU - Hill, J. O. PY - 2011 DA - 2011// TI - Trends in carbohydrate, fat, and protein intakes and association with energy intake in normal-weight, overweight, and obese individuals: 1971-2006 JO - Am J Clin Nutr VL - 93 UR - https://doi.org/10.3945/ajcn.110.000141 DO - 10.3945/ajcn.110.000141 ID - Austin2011 ER - TY - JOUR AU - Berry, S. E. PY - 2009 DA - 2009// TI - Triacylglycerol structure and interesterification of palmitic and stearic acid-rich fats: an overview and implications for cardiovascular disease JO - Nutr Res Rev VL - 22 UR - https://doi.org/10.1017/S0954422409369267 DO - 10.1017/S0954422409369267 ID - Berry2009 ER - TY - JOUR AU - Bosch, J. AU - Berg, S. A. AU - Bijland, S. AU - Voshol, P. J. AU - Havekes, L. M. AU - Romijn, H. A. PY - 2011 DA - 2011// TI - High-fat diets rich in medium- versus long-chain fatty acids induce distinct patterns of tissue specific insulin resistance JO - J Nutr Biochem VL - 22 UR - https://doi.org/10.1016/j.jnutbio.2010.03.004 DO - 10.1016/j.jnutbio.2010.03.004 ID - Bosch2011 ER - TY - JOUR AU - Leyton, J. AU - Drury, P. J. AU - Crawford, M. A. PY - 1987 DA - 1987// TI - Differential oxidation of saturated and unsaturated fatty acids in vivo in the rat JO - Br J Nutr VL - 57 UR - https://doi.org/10.1079/BJN19870046 DO - 10.1079/BJN19870046 ID - Leyton1987 ER - TY - JOUR AU - Pai, T. AU - Yeh, Y. Y. PY - 1996 DA - 1996// TI - Stearic acid unlike shorter-chain saturated fatty acids is poorly utilized for triacylglycerol synthesis and beta-oxidation in cultured rat hepatocytes JO - Lipids VL - 31 UR - https://doi.org/10.1007/BF02522615 DO - 10.1007/BF02522615 ID - Pai1996 ER - TY - JOUR AU - DeLany, J. P. AU - Windhauser, M. M. AU - Champagne, C. M. AU - Bray, G. A. PY - 2000 DA - 2000// TI - Differential oxidation of individual dietary fatty acids in humans JO - Am J Clin Nutr VL - 72 ID - DeLany2000 ER - TY - JOUR AU - Pai, T. AU - Yeh, Y. Y. PY - 1997 DA - 1997// TI - Stearic acid modifies very low density lipoprotein lipid composition and particle size differently from shorter-chain saturated fatty acids in cultured rat hepatocytes JO - Lipids VL - 32 UR - https://doi.org/10.1007/s11745-997-0018-z DO - 10.1007/s11745-997-0018-z ID - Pai1997 ER - TY - JOUR AU - Bruce, J. S. AU - Salter, A. M. PY - 1996 DA - 1996// TI - Metabolic fate of oleic acid, palmitic acid and stearic acid in cultured hamster hepatocytes JO - Biochem J VL - 316 UR - https://doi.org/10.1042/bj3160847 DO - 10.1042/bj3160847 ID - Bruce1996 ER - TY - JOUR AU - Hommelberg, P. P. AU - Plat, J. AU - Langen, R. C. AU - Schols, A. M. AU - Mensink, R. P. PY - 2009 DA - 2009// TI - Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent JO - Am J Physiol Endocrinol Metab VL - 296 UR - https://doi.org/10.1152/ajpendo.00436.2007 DO - 10.1152/ajpendo.00436.2007 ID - Hommelberg2009 ER - TY - JOUR AU - Berg, S. A. AU - Guigas, B. AU - Bijland, S. AU - Ouwens, M. AU - Voshol, P. J. AU - Frants, R. R. PY - 2010 DA - 2010// TI - High levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity JO - Nutr Metab (Lond) VL - 7 UR - https://doi.org/10.1186/1743-7075-7-24 DO - 10.1186/1743-7075-7-24 ID - Berg2010 ER - TY - JOUR AU - Samuel, V. T. AU - Petersen, K. F. AU - Shulman, G. I. PY - 2010 DA - 2010// TI - Lipid-induced insulin resistance: unravelling the mechanism JO - Lancet VL - 375 UR - https://doi.org/10.1016/S0140-6736(10)60408-4 DO - 10.1016/S0140-6736(10)60408-4 ID - Samuel2010 ER - TY - JOUR AU - Szczepaniak, L. S. AU - Nurenberg, P. AU - Leonard, D. AU - Browning, J. D. AU - Reingold, J. S. AU - Grundy, S. PY - 2005 DA - 2005// TI - Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population JO - Am J Physiol Endocrinol Metab VL - 288 UR - https://doi.org/10.1152/ajpendo.00064.2004 DO - 10.1152/ajpendo.00064.2004 ID - Szczepaniak2005 ER - TY - JOUR AU - Hamilton, G. AU - Yokoo, T. AU - Bydder, M. AU - Cruite, I. AU - Schroeder, M. E. AU - Sirlin, C. B. PY - 2011 DA - 2011// TI - In vivo characterization of the liver fat 1H MR spectrum JO - NMR Biomed VL - 24 UR - https://doi.org/10.1002/nbm.1622 DO - 10.1002/nbm.1622 ID - Hamilton2011 ER - TY - JOUR AU - Marsman, H. A. AU - Werven, J. R. AU - Nederveen, A. J. AU - Kate, F. J. AU - Heger, M. AU - Stoker, J. PY - 2010 DA - 2010// TI - Noninvasive quantification of hepatic steatosis in rats using 3.0 T 1H-magnetic resonance spectroscopy JO - J Magn Reson Imaging VL - 32 UR - https://doi.org/10.1002/jmri.22064 DO - 10.1002/jmri.22064 ID - Marsman2010 ER - TY - JOUR AU - Jonkers, R. A. AU - Geraedts, T. R. AU - Loon, L. J. AU - Nicolay, K. AU - Prompers, J. J. PY - 2012 DA - 2012// TI - Multitissue assessment of in vivo postprandial intracellular lipid partitioning in rats using localized 1H-[13C] magnetic resonance spectroscopy JO - Magn Reson Med VL - 68 UR - https://doi.org/10.1002/mrm.23321 DO - 10.1002/mrm.23321 ID - Jonkers2012 ER - TY - JOUR AU - Jonkers, R. A. AU - Loon, L. J. AU - Nicolay, K. AU - Prompers, J. J. PY - 2013 DA - 2013// TI - In vivo postprandial lipid partitioning in liver and skeletal muscle in prediabetic and diabetic rats JO - Diabetologia VL - 56 UR - https://doi.org/10.1007/s00125-012-2792-x DO - 10.1007/s00125-012-2792-x ID - Jonkers2013 ER - TY - JOUR AU - Zambon, A. AU - Hashimoto, S. I. AU - Brunzell, J. D. PY - 1993 DA - 1993// TI - Analysis of techniques to obtain plasma for measurement of levels of free fatty acids JO - J Lipid Res VL - 34 ID - Zambon1993 ER - TY - JOUR AU - Garwood, M. AU - DelaBarre, L. PY - 2001 DA - 2001// TI - The return of the frequency sweep: designing adiabatic pulses for contemporary NMR JO - J Magn Reson VL - 153 UR - https://doi.org/10.1006/jmre.2001.2340 DO - 10.1006/jmre.2001.2340 ID - Garwood2001 ER - TY - JOUR AU - Rothman, D. L. AU - Behar, K. L. AU - Hetherington, H. P. AU - Hollander, J. A. AU - Bendall, M. R. AU - Petroff, O. A. PY - 1985 DA - 1985// TI - 1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo JO - Proc Natl Acad Sci U S A VL - 82 UR - https://doi.org/10.1073/pnas.82.6.1633 DO - 10.1073/pnas.82.6.1633 ID - Rothman1985 ER - TY - JOUR AU - Graaf, R. A. AU - Brown, P. B. AU - Mason, G. F. AU - Rothman, D. L. AU - Behar, K. L. PY - 2003 DA - 2003// TI - Detection of [1,6-13C2]-glucose metabolism in rat brain by in vivo 1H-[13C]-NMR spectroscopy JO - Magn Reson Med VL - 49 UR - https://doi.org/10.1002/mrm.10348 DO - 10.1002/mrm.10348 ID - Graaf2003 ER - TY - JOUR AU - Graaf, R. A. AU - Nicolay, K. PY - 1998 DA - 1998// TI - Adiabatic water suppression using frequency selective excitation JO - Magn Reson Med VL - 40 UR - https://doi.org/10.1002/mrm.1910400508 DO - 10.1002/mrm.1910400508 ID - Graaf1998 ER - TY - JOUR AU - Mildaziene, V. AU - Nauciene, Z. AU - Baniene, R. AU - Grigiene, J. PY - 2002 DA - 2002// TI - Multiple effects of 2,2’,5,5’-tetrachlorobiphenyl on oxidative phosphorylation in rat liver mitochondria JO - Toxicol Sci VL - 65 UR - https://doi.org/10.1093/toxsci/65.2.220 DO - 10.1093/toxsci/65.2.220 ID - Mildaziene2002 ER - TY - JOUR AU - Reaven, G. M. PY - 2009 DA - 2009// TI - Insulin secretory function in type 2 diabetes: Does it matter how you measure it? JO - J Diabetes VL - 1 UR - https://doi.org/10.1111/j.1753-0407.2009.00016.x DO - 10.1111/j.1753-0407.2009.00016.x ID - Reaven2009 ER - TY - JOUR AU - Reinauer, H. AU - Gries, F. A. AU - Hubinger, A. AU - Knode, O. AU - Severing, K. AU - Susanto, F. PY - 1990 DA - 1990// TI - Determination of glucose turnover and glucose oxidation rates in man with stable isotope tracers JO - J Clin Chem Clin Biochem VL - 28 ID - Reinauer1990 ER - TY - JOUR AU - Hussaarts, L. AU - Garcia-Tardon, N. AU - Beek, L. AU - Heemskerk, M. M. AU - Haeberlein, S. AU - Zon, G. C. PY - 2015 DA - 2015// TI - Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice JO - FASEB J VL - 29 UR - https://doi.org/10.1096/fj.14-266239 DO - 10.1096/fj.14-266239 ID - Hussaarts2015 ER - TY - JOUR AU - Millar, J. S. AU - Cromley, D. A. AU - McCoy, M. G. AU - Rader, D. J. AU - Billheimer, J. T. PY - 2005 DA - 2005// TI - Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339 JO - J Lipid Res VL - 46 UR - https://doi.org/10.1194/jlr.D500019-JLR200 DO - 10.1194/jlr.D500019-JLR200 ID - Millar2005 ER - TY - JOUR AU - Ikemoto, S. AU - Takahashi, M. AU - Tsunoda, N. AU - Maruyama, K. AU - Itakura, H. AU - Ezaki, O. PY - 1996 DA - 1996// TI - High-fat diet-induced hyperglycemia and obesity in mice: differential effects of dietary oils JO - Metabolism VL - 45 UR - https://doi.org/10.1016/S0026-0495(96)90185-7 DO - 10.1016/S0026-0495(96)90185-7 ID - Ikemoto1996 ER - TY - JOUR AU - Lai, M. AU - Chandrasekera, P. C. AU - Barnard, N. D. PY - 2014 DA - 2014// TI - You are what you eat, or are you? The challenges of translating high-fat-fed rodents to human obesity and diabetes JO - Nutr Diabetes VL - 4 UR - https://doi.org/10.1038/nutd.2014.30 DO - 10.1038/nutd.2014.30 ID - Lai2014 ER - TY - JOUR AU - Ciapaite, J. AU - Broek, N. M. AU - Brinke, H. AU - Nicolay, K. AU - Jeneson, J. A. AU - Houten, S. M. PY - 1811 DA - 1811// TI - Differential effects of short- and long-term high-fat diet feeding on hepatic fatty acid metabolism in rats JO - Biochim Biophys Acta VL - 2011 ID - Ciapaite1811 ER - TY - JOUR AU - Teodoro, J. S. AU - Rolo, A. P. AU - Duarte, F. V. AU - Simoes, A. M. AU - Palmeira, C. M. PY - 2008 DA - 2008// TI - Differential alterations in mitochondrial function induced by a choline-deficient diet: understanding fatty liver disease progression JO - Mitochondrion VL - 8 UR - https://doi.org/10.1016/j.mito.2008.07.008 DO - 10.1016/j.mito.2008.07.008 ID - Teodoro2008 ER - TY - JOUR AU - Lionetti, L. AU - Mollica, M. P. AU - Donizzetti, I. AU - Gifuni, G. AU - Sica, R. AU - Pignalosa, A. PY - 2014 DA - 2014// TI - High-lard and high-fish-oil diets differ in their effects on function and dynamic behaviour of rat hepatic mitochondria JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0092753 DO - 10.1371/journal.pone.0092753 ID - Lionetti2014 ER - TY - JOUR AU - Chen, Y. D. AU - Swami, S. AU - Skowronski, R. AU - Coulston, A. AU - Reaven, G. M. PY - 1993 DA - 1993// TI - Differences in postprandial lipemia between patients with normal glucose tolerance and noninsulin-dependent diabetes mellitus JO - J Clin Endocrinol Metab VL - 76 ID - Chen1993 ER - TY - JOUR AU - Chen, Y. D. AU - Coulston, A. M. AU - Zhou, M. Y. AU - Hollenbeck, C. B. AU - Reaven, G. M. PY - 1995 DA - 1995// TI - Why do low-fat high-carbohydrate diets accentuate postprandial lipemia in patients with NIDDM? JO - Diabetes Care VL - 18 UR - https://doi.org/10.2337/diacare.18.1.10 DO - 10.2337/diacare.18.1.10 ID - Chen1995 ER - TY - JOUR AU - Cooper, A. D. PY - 1997 DA - 1997// TI - Hepatic uptake of chylomicron remnants JO - J Lipid Res VL - 38 ID - Cooper1997 ER - TY - JOUR AU - Redgrave, T. G. AU - Callow, M. J. PY - 1990 DA - 1990// TI - The effect of insulin deficiency on the metabolism of lipid emulsion models of triacylglycerol-rich lipoproteins in rats JO - Metabolism VL - 39 UR - https://doi.org/10.1016/0026-0495(90)90140-8 DO - 10.1016/0026-0495(90)90140-8 ID - Redgrave1990 ER - TY - JOUR AU - Mamo, J. C. AU - Elsegood, C. L. AU - Umeda, Y. AU - Hirano, T. AU - Redgrave, T. G. PY - 1993 DA - 1993// TI - Effect of probucol on plasma clearance and organ uptake of chylomicrons and VLDLs in normal and diabetic rats JO - Arterioscler Thromb VL - 13 UR - https://doi.org/10.1161/01.ATV.13.2.231 DO - 10.1161/01.ATV.13.2.231 ID - Mamo1993 ER - TY - JOUR AU - Jones, P. J. AU - Pencharz, P. B. AU - Clandinin, M. T. PY - 1985 DA - 1985// TI - Whole body oxidation of dietary fatty acids: implications for energy utilization JO - Am J Clin Nutr VL - 42 ID - Jones1985 ER - TY - JOUR AU - Bonanome, A. AU - Grundy, S. M. PY - 1989 DA - 1989// TI - Intestinal absorption of stearic acid after consumption of high fat meals in humans JO - J Nutr VL - 119 ID - Bonanome1989 ER - TY - JOUR AU - Chavez, J. A. AU - Summers, S. A. PY - 2003 DA - 2003// TI - Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3 T3-L1 adipocytes and C2C12 myotubes JO - Arch Biochem Biophys VL - 419 UR - https://doi.org/10.1016/j.abb.2003.08.020 DO - 10.1016/j.abb.2003.08.020 ID - Chavez2003 ER - TY - JOUR AU - Hotamisligil, G. S. AU - Erbay, E. PY - 2008 DA - 2008// TI - Nutrient sensing and inflammation in metabolic diseases JO - Nat Rev Immunol VL - 8 UR - https://doi.org/10.1038/nri2449 DO - 10.1038/nri2449 ID - Hotamisligil2008 ER - TY - JOUR AU - Schaeffler, A. AU - Gross, P. AU - Buettner, R. AU - Bollheimer, C. AU - Buechler, C. AU - Neumeier, M. PY - 2009 DA - 2009// TI - Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity JO - Immunology VL - 126 UR - https://doi.org/10.1111/j.1365-2567.2008.02892.x DO - 10.1111/j.1365-2567.2008.02892.x ID - Schaeffler2009 ER - TY - JOUR AU - Shi, H. AU - Kokoeva, M. V. AU - Inouye, K. AU - Tzameli, I. AU - Yin, H. AU - Flier, J. S. PY - 2006 DA - 2006// TI - TLR4 links innate immunity and fatty acid-induced insulin resistance JO - J Clin Invest VL - 116 UR - https://doi.org/10.1172/JCI28898 DO - 10.1172/JCI28898 ID - Shi2006 ER - TY - JOUR AU - Funari, S. S. AU - Barcelo, F. AU - Escriba, P. V. PY - 2003 DA - 2003// TI - Effects of oleic acid and its congeners, elaidic and stearic acids, on the structural properties of phosphatidylethanolamine membranes JO - J Lipid Res VL - 44 UR - https://doi.org/10.1194/jlr.M200356-JLR200 DO - 10.1194/jlr.M200356-JLR200 ID - Funari2003 ER - TY - JOUR AU - Hac-Wydro, K. AU - Wydro, P. PY - 2007 DA - 2007// TI - The influence of fatty acids on model cholesterol/phospholipid membranes JO - Chem Phys Lipids VL - 150 UR - https://doi.org/10.1016/j.chemphyslip.2007.06.213 DO - 10.1016/j.chemphyslip.2007.06.213 ID - Hac-Wydro2007 ER - TY - JOUR AU - Maxfield, F. R. AU - Tabas, I. PY - 2005 DA - 2005// TI - Role of cholesterol and lipid organization in disease JO - Nature VL - 438 UR - https://doi.org/10.1038/nature04399 DO - 10.1038/nature04399 ID - Maxfield2005 ER -