Fig. 2

Glucose and insulin sensitivity related parameters. a Plasma glucose levels (Glu, n = 15-18); (b) Glucose tolerance test (GTT, n = 15-16); (c) Area under curve of glucose tolerance test; (d) serum insulin levels (n = 12); (e) Insulin tolerance test (ITT, n = 12); (f) Area under curve of insulin tolerance test; (g) Representative Western blot images for the proteins in liver; h The quantification by densitometry of phosphorylated AKT (p-AKT) normalized to total (n = 6); (i) The quantification by densitometry of IRS1 (n = 6); (j) Related gene expressions of insulin sensitivity in the liver (n = 12). WT, wild type mice; SKO, seipin knockout mice; NC, normal chow diet;D/E, DHA/EPA 3:1 diet. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, SKO NC group compared with WT NC group; #P < 0.05, ##P < 0.01, ###P < 0.001, SKO D/E group compared with SKO NC group