Fig. 3

Lipolysis rates (in the basal and isoproterenol-stimulated conditions) of apoCIII transgenic (Tg) and non-transgenic (NTg) mice after 8 weeks of high fat diet measured in isolated adipocytes (a-b) (n = 6, two independent experiments) and in vivo (c-e) (n = 13-15). Adipocytes (10⁶) isolated from fed mice were incubated for 1.5 hours at 37°C in the presence of 0.2 U/ml adenosine deaminase, with or without 10⁻⁵ M isoproterenol. Lipolysis index in fed mice is estimated as the ratio of glycerol plasma levels in the isoproterenol-stimulated over basal conditions. Mean ± SE. Student’s t test, *P ≤ 0.05; **P ≤ 0.01