Fig. 3

aP2-Cre mediated MTP ablation reduces body weight and lipid accumulation in the adipose tissue. Mttp ^fl/fl and A-Mttp ^−/− mice were fed a HFD for 24 weeks. At the end of the experiment, control and A-Mttp ^−/− mice were sacrificed and organs collected for MTP mRNA measurement (a) and MTP activity (b). Representative pictures of visceral fat pads and animal morphology are shown in panel (c). Percentages of fat in different adipose tissues by gram body weight are plotted in (d). Body weights were recorded every 2 weeks during the experiment using female (e) and male mice (f). Data for food consumption and body temperature are represented in (g & h). Values are mean of 5–7 mice ± SD from each group. *, p < 0.05; **, p < 0.01; and ***, p < 0.001