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Fig. 9 | Nutrition & Metabolism

Fig. 9

From: Mice subjected to aP2-Cre mediated ablation of microsomal triglyceride transfer protein are resistant to high fat diet induced obesity

Fig. 9

A-Mttp −/− mice absorb fewer lipids after a fat tolerance test. Control Mttp fl/fl and A-Mttp −/− mice were fed 60 % HFD for 15 weeks. (a) Postprandial triglyceridemic response was measured in control Mttp fl/fl and A-Mttp −/− mice. Plasma triglyceride concentration was measured at baseline (4 h fasting) and at 2 h and 4 h following oral challenge of 200 μl olive oil. Data are represented as mean ± SD (N = 3). (b) After 4 h fasting, mice were injected with P407 in the intraperitoneal cavity to block lipase activity in the circulation. After 30 min, mice were administered 200 μl olive oil (oral gavage) and plasma triglycerides were measured before and at 2 h and 4 h post oil bolus. Data are represented as mean ± SD (N = 4). *, p < 0.05 and **, p < 0.01

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