Table 3 Identification of plasma metabolites at baseline and 12-week follow-up

L-Valine

C₅H₁₁NO₂

118.0868

1,338,114 ± 39,666

1,323,676 ± 36,213

1,328,470 ± 41,793

1,376,655 ± 34,768

0.7807

0.1901

1.0144

L-Leucine

C₆H₁₃NO₂

132.1025

3,130,607 ± 99,839

3,098,031 ± 98,593

3,130,777 ± 107,368

3,166,315 ± 85,278

0.4904

0.5781

0.7853

L-Phenylalanine

C₉H₁₁NO₂

166.0868

1,984,169 ± 49,821

1,914,567 ± 45,393

1,997,467 ± 84,582

1,975,319 ± 41,491

0.6137

1.1072

0.7382

Oleamide

C₁₈H₃₅NO

282.2797

11,074,949 ± 815,519

11,182,173 ± 1,054,856

11,348,184 ± 805,164

12,102,398 ± 709,965

8.4316

19.2720

6.6270

C17 Sphinganine

C₁₇H₃₇NO₂

288.2903

323,013 ± 20,549

441,137 ± 24,748^*

333,258 ± 29,775

355,950 ± 25,250

0.9135

1.3462

0.1114

(4E,8E,10E-d18:3) Sphingosine

C₁₈H₃₃NO₂

296.2590

420,731 ± 59,507

832,979 ± 152,996

608,061 ± 81,037

754,737 ± 66,758

1.5120

8.8050

2.2736

Anandamide (18:4, n-3)

C₂₀H₃₃NO₂

320.2590

170,194 ± 28,584

237,343 ± 31,518

209,059 ± 26,262

213,643 ± 16,101

0.1156

1.4954

0.5840

LysoPC (14:0)

C₂₂H₄₆NO₇P

468.3090

480,474 ± 33,898

503,684 ± 38,015

625,962 ± 45,904

537,767 ± 45,983

1.5352

0.7142

0.2242

LysoPC (16:1)

C₂₄H₄₈NO₇P

494.3247

1,133,250 ± 77,052

1,033,013 ± 69,288

1,261,066 ± 78,064

1,127,811 ± 88,549

2.3243

1.4177

1.0354

LysoPC (16:0)

C₂₄H₅₀NO₇P

496.3403

15,953,932 ± 573,566

15,910,457 ± 684,453

16,830,932 ± 686,817

15,967,767 ± 537,944

15.3974

7.7607

4.7470

LysoPC (17:0)

C₂₅H₅₂NO₇P

510.3560

689,578 ± 58,089

710,335 ± 73,384

758,848 ± 49,685

733,637 ± 53,343

0.5841

1.3389

0.1217

LysoPC (18:3)

C₂₆H₄₈NO₇P

518.3247

620,814 ± 20,714

591,900 ± 19,836

658,460 ± 22,577

675,799 ± 31,645

0.1217

0.3985

1.1643

LysoPC (18:2)

C₂₆H₅₀NO₇P

520.3403

6,388,637 ± 262,115

6,025,486 ± 300,959

6,617,717 ± 260,021

6,878,238 ± 274,508

2.2535

4.8170

15.1889

LysoPC (18:1)

C₂₆H₅₂NO₇P

522.3560

5,375,808 ± 229,038

5,364,828 ± 250,194

5,593,899 ± 214,117

5,425,134 ± 241,245

4.2976

3.7059

4.2779

LysoPC (18:0)

C₂₆H₅₄NO₇P

524.3716

5,661,866 ± 195,118

5,610,496 ± 261,241

5,976,007 ± 255,107

5,830,224 ± 224,489

2.5863

3.3556

5.4463

LysoPC (20:5)

C₂₈H₄₈NO₇P

542.3247

771,884 ± 61,530

784,374 ± 53,112

997,008 ± 89,800

876,925 ± 59,723

2.1218

0.4055

1.2595

LysoPC (20:4)

C₂₈H₅₀NO₇P

544.3403

2,512,566 ± 118,266

2,294,343 ± 118,562

2,188,892 ± 126,719

1,958,744 ± 83,560

2.9839

3.3959

6.5629

LysoPC (22:6)

C₃₀H₅₀NO₇P

568.3403

1,268,789 ± 89,205

1,160,444 ± 72,253

1,322,936 ± 96,792

1,153,481 ± 79,319

1.8183

1.6819

0.2714

SM (d18:0/16:1)

C₃₉H₇₉N₂O₆P

703.5754

918,463 ± 110,095

628,987 ± 81,863

1,046,537 ± 118,533

1,088,608 ± 142,939

0.9346

4.2113

7.9088

Lactosylceramide (d18:1/12:0)

C₄₂H₇₉NO₁₃

806.5630

5,977,825 ± 630,100

8,134,712 ± 703,408

6,832,476 ± 741,718

5,908,934 ± 712,523

4.8718

8.3007

5.9197

¹PCs

44,523,937 ± 2,514,233

44,154,177 ± 1,968,873

43,454,754 ± 2,366,214

50,137,749 ± 2,118,552