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Table 2 Evolution of metabolic parameters during the study

From: High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications

M2 ND HF HFD HFHF
Weight (g) 442 ± 610 462 ± 8 543 ± 14* 553 ± 14*
Fasting Leptin (ng/mL) 8.19 ± 0.44 10.84 ± 0.75** 20.86 ± 0.79*** 17.05 ± 1.68*** a
Fasting glycaemia (mg/dL) 89 ± 4 102 ± 6 128 ± 6*** 112 ± 6**
Peptide-C (pmol/L) Fasting 1027.8 ± 71.4 2340.2 ± 73.7*** 1404.5 ± 73.7*** 2282.6 ± 187.9***
Non-fasting 1974.5 ± 163.8 5222.9 ± 374.1*** 3578.2 ± 256*** 4531.3 ± 432.8***
Insulin resistance (HOMA2-IR) 2.20 ± 0.15 3.35 ± 0.33 6.59 ± 0.67*** 5.36 ± 0.79*
Total cholesterol (mM) 2.92 ± 0.41 4.0 ± 0.80 3.44 ± 0.48 5.03 ± 0.73*
  1. Effects of diet on body weight and metabolic parameters during the study, after 2 (M2) of normal diet (ND), normal diet + fructose (HF), high fat diet (HFD) and HFD + fructose (HFHF). In bold significant difference with age-matched ND rats and abetween HFD- and HFHF-rats. *p<0.05, **p<0.01, ***p<0.001