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Table 2 Evolution of metabolic parameters during the study

From: High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications

M2

ND

HF

HFD

HFHF

Weight (g)

442 ± 610

462 ± 8

543 ± 14*

553 ± 14*

Fasting Leptin (ng/mL)

8.19 ± 0.44

10.84 ± 0.75**

20.86 ± 0.79***

17.05 ± 1.68*** a

Fasting glycaemia (mg/dL)

89 ± 4

102 ± 6

128 ± 6***

112 ± 6**

Peptide-C (pmol/L) Fasting

1027.8 ± 71.4

2340.2 ± 73.7***

1404.5 ± 73.7***

2282.6 ± 187.9***

Non-fasting

1974.5 ± 163.8

5222.9 ± 374.1***

3578.2 ± 256***

4531.3 ± 432.8***

Insulin resistance (HOMA2-IR)

2.20 ± 0.15

3.35 ± 0.33

6.59 ± 0.67***

5.36 ± 0.79*

Total cholesterol (mM)

2.92 ± 0.41

4.0 ± 0.80

3.44 ± 0.48

5.03 ± 0.73*

  1. Effects of diet on body weight and metabolic parameters during the study, after 2 (M2) of normal diet (ND), normal diet + fructose (HF), high fat diet (HFD) and HFD + fructose (HFHF). In bold significant difference with age-matched ND rats and abetween HFD- and HFHF-rats. *p<0.05, **p<0.01, ***p<0.001