|
M2
|
ND
|
HF
|
HFD
|
HFHF
|
|---|
|
Weight (g)
|
442 ± 610
|
462 ± 8
|
543 ± 14*
|
553 ± 14*
|
|
Fasting Leptin (ng/mL)
|
8.19 ± 0.44
|
10.84 ± 0.75**
|
20.86 ± 0.79***
|
17.05 ± 1.68***
a
|
|
Fasting glycaemia (mg/dL)
|
89 ± 4
|
102 ± 6
|
128 ± 6***
|
112 ± 6**
|
|
Peptide-C (pmol/L) Fasting
|
1027.8 ± 71.4
|
2340.2 ± 73.7***
|
1404.5 ± 73.7***
|
2282.6 ± 187.9***
|
|
Non-fasting
|
1974.5 ± 163.8
|
5222.9 ± 374.1***
|
3578.2 ± 256***
|
4531.3 ± 432.8***
|
|
Insulin resistance (HOMA2-IR)
|
2.20 ± 0.15
|
3.35 ± 0.33
|
6.59 ± 0.67***
|
5.36 ± 0.79*
|
|
Total cholesterol (mM)
|
2.92 ± 0.41
|
4.0 ± 0.80
|
3.44 ± 0.48
|
5.03 ± 0.73*
|
- Effects of diet on body weight and metabolic parameters during the study, after 2 (M2) of normal diet (ND), normal diet + fructose (HF), high fat diet (HFD) and HFD + fructose (HFHF). In bold significant difference with age-matched ND rats and abetween HFD- and HFHF-rats. *p<0.05, **p<0.01, ***p<0.001
