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Table 3 Evolution of metabolic parameters during the study

From: High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications

M8

ND

HF

HFD

HFHF

Weight (g)

617 ± 9

680 ± 22

863 ± 70***

863 ± 72***

Fasting Leptin (ng/mL)

22.41 ± 1.48

26.13 ± 1.45

91.17 ± 13.8**

124.11 ± 5.09** b

Fasting glycaemia (mg/dL)

124 ± 5

122 ± 4

116 ± 2

137 ± 2* b

Peptide-C (pmol/L) Fasting

1871.8 ± 259

2060.7 ± 180.0

2730 ± 365.1

3937.3 ± 4953.1*

Non-fasting

3534.8 ± 185.8

6081.3 ± 987.2

6615 ± 828.3*

12411.7 ± 2072.4** a

Insulin resistance (HOMA2-IR)

4.53 ± 0.62

4.97 ± 0.44

5.7 ± 0.82

9.78 ± 1.24***

Total cholesterol (mM)

1.76 ± 0.24

2.44 ± 0.51

3.0 ± 0.59

4.23 ± 0.47*

  1. Effects of diet on body weight and metabolic parameters during the study, after 8 months (M8) of normal diet (ND), normal diet + fructose (HF), high fat diet (HFD) and HFD + fructose (HFHF). In bold significant difference with * vs. age-matched ND rats and a, bbetween HFD- and HFHF-rats. *p<0.05; **p<0.01; ***p<0.001 and a p<0.05 and b p<0.001
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Nutrition & Metabolism

ISSN: 1743-7075

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