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Table 3 Evolution of metabolic parameters during the study

From: High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications

M8 ND HF HFD HFHF
Weight (g) 617 ± 9 680 ± 22 863 ± 70*** 863 ± 72***
Fasting Leptin (ng/mL) 22.41 ± 1.48 26.13 ± 1.45 91.17 ± 13.8** 124.11 ± 5.09** b
Fasting glycaemia (mg/dL) 124 ± 5 122 ± 4 116 ± 2 137 ± 2* b
Peptide-C (pmol/L) Fasting 1871.8 ± 259 2060.7 ± 180.0 2730 ± 365.1 3937.3 ± 4953.1*
Non-fasting 3534.8 ± 185.8 6081.3 ± 987.2 6615 ± 828.3* 12411.7 ± 2072.4** a
Insulin resistance (HOMA2-IR) 4.53 ± 0.62 4.97 ± 0.44 5.7 ± 0.82 9.78 ± 1.24***
Total cholesterol (mM) 1.76 ± 0.24 2.44 ± 0.51 3.0 ± 0.59 4.23 ± 0.47*
  1. Effects of diet on body weight and metabolic parameters during the study, after 8 months (M8) of normal diet (ND), normal diet + fructose (HF), high fat diet (HFD) and HFD + fructose (HFHF). In bold significant difference with * vs. age-matched ND rats and a, bbetween HFD- and HFHF-rats. *p<0.05; **p<0.01; ***p<0.001 and a p<0.05 and b p<0.001