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Table 4 Evolution of inflammatory and oxidative parameters during the study

From: High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications

M0 Ctr M0 Ctr
Plasmatic parameters   Hepatic parameters  
 TNFα (pg/mL) 37.30 ± 13.68 Macrophages (% of area) 1.91 ± 0.4
 TAOC (mmol/L trolox equivalent) 10.51 ± 0.29 Oxidative stress (% vs. age-matched ND) 100 ± 22.9
 Lipids peroxidation (μmol/L TBARS) 20.6 ± 3.2 SOD activity (% inhibition rate) 0.97 ± 0.003
   Catalase activity (μmol/L) 0.272 ± 0.03
   Lipids peroxidation (μmol/L TBARS) 23 ± 0.8
M2 ND HF HFD HFHF
Plasmatic parameters     
 TNFα (pg/mL) 23.23 ± 7.82 13.63 ± 3.52 49.03 ± 20.06 13.84 ± 5.46
 TAOC (mmol/L trolox equivalent) 7.64 ± 0.15 7.93 ± 0.16 7.58 ± 0.45 8.32 ± 0.25
 Lipids peroxidation (μmol/L TBARS) 19.4 ± 2.0 41.9 ± 10.5 26.5 ± 5.3 43.3 ± 13.1
Hepatic parameters     
 Macrophages (% of area) 4.34 ± 1.1 2.88 ± 1.2 2.58 ± 0.8 4.10 ± 2.1
 Oxidative stress (% vs. age-matched ND) 100 ± 11.4 108.1 ± 17.7 168.2 ± 17.3* 151 ± 17.9*
 SOD activity (% inhibition rate) 1.15 ± 0.13 0.99 ± 0.008 1.17 ± 0.09 1.08 ± 0.07
 Catalase activity (μmol/L) 0.243 ± 0.03 0.187 ± 0.02 0.283 ± 0.04 0.257 ± 0.02
 Lipids peroxidation (μmol/L TBARS) 20.4 ± 1.1 23.9 ± 0.1** 19.4 ± 0.7 18 ± 1.4
M8 ND HF HFD HFHF
Plasmatic parameters     
 TNFα (pg/mL) 25.63 ± 7.57 48.90 ± 9.74 97.98 ± 28.42* 130.7 ± 40.68***
 TAOC (mmol/L trolox equivalent) 11.07 ± 0.08 11.24 ± 0.19 10.96 ± 0.09 11.10 ± 0.27
 Lipids peroxidation (μmol/L TBARS) 20.1 ± 2.5 22.5 ± 3.3 38.8 ± 3.8** 48.0 ± 6.3*
Hepatic parameters     
 Macrophages (% of area) 2.20 ± 1.5 2.37 ± 1.1 5.99 ± 1.9 11.26 ± 2.4** a
 Oxidative stress (% vs. age-matched ND) 100 ± 6.3 110.2 ± 21.5 149.2 ± 15.3 206 ± 29.1** a
 SOD activity (% inhibition rate) 1.09 ± 0.04 0.94 ± 0.08 1.13 ± 0.14 1.17 ± 0.16
 Catalase activity (μmol/L) 0.246 ± 0.03 0.120 ± 0.03** 0.207 ± 0.03 0.232 ± 0.01
 Lipids peroxidation (μmol/L TBARS) 18 ± 1.2 15.7 ± 2.0 18.9 ± 2.1 16.5 ± 1.1
  1. Effects of diet on plasmatic and hepatic inflammation and oxidative parameters during the study, at the beginning (M0) and after 2 (M2) and 8 months (M8) of normal diet (ND), normal diet + fructose (HF), high fat diet (HFD) and HFD + fructose (HFHF). In bold significant difference with age-matched ND rats and abetween HFD- and HFHF-rats. *p<0.05, **p<0.01, ***p<0.001