Fig. 4

Morphology, number and area distribution of islets from aP2-CETPTg mice. a Representative pancreas sections of aP2-CETPTg mice and WT mice were stained with hematoxylin and eosin for histological analysis. Original magnification, ×50 (left panels); ×100 (right panels). Islets are marked with asterisk and arrow. b The area distribution of islets on H-E staining pancreas sections. (aP2-CETPTg, n = 9; WT, n = 10; 10 sections at two separate levels per mouse pancreas). Islets from aP2-CETPTg mice were smaller in size than that from WT mice. c Area quantification of islets on pancreas sections displayed significant decreased area in aP2-CETPTg mice. d Pancreatic islets were isolated from aP2-CETPTg mice and WT mice (n = 6 per group) and double-blinded counted by two persons. Islets isolated from aP2-CETPTg mice were fewer than that from WT mice. Values are expressed as mean ± SD. **p < 0.01, compared with control group