TY - JOUR AU - Manzano, Manuel AU - Giron, María D. AU - Vilchez, José D. AU - Sevillano, Natalia AU - El-Azem, Nuri AU - Rueda, Ricardo AU - Salto, Rafael AU - Lopez-Pedrosa, Jose M. PY - 2016 DA - 2016/04/30 TI - Apple polyphenol extract improves insulin sensitivity in vitro and in vivo in animal models of insulin resistance JO - Nutrition & Metabolism SP - 32 VL - 13 IS - 1 AB - Apple polyphenols could represent a novel nutritional approach in the management and control of blood glucose, especially in type 2 diabetics. The aim of this study was to test the therapeutic potential of an apple polyphenol extract (APE) in an insulin-resistant rat model and to determine the molecular basis of insulin sensitivity action in skeletal muscle cells. SN - 1743-7075 UR - https://doi.org/10.1186/s12986-016-0088-8 DO - 10.1186/s12986-016-0088-8 ID - Manzano2016 ER -