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Table 1 Predominant localization of the major metabolic functions and proteins in zones of hepatocytes

From: Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism

Periportal zone Perivenous zone References
Metabolic function Protein Metabolic function Protein
Lipid metabolism
Fatty-acid oxidation, Cholesterol synthesis 3-hydroxyacyl-CoA dehydrogenase, CPI Lipogenesis ACC, ACL, FAS, [1012, 14, 15, 56, 57]
Ketogenesis β-hydroxybutyrate dehydrogenase,
Bile acid synthesis
Glucose metabolism
Gluconeogenesis G6Pas, FBPas, PEPCK, Lactate dehydrogenase Glycolysis GK, PKL [10, 11, 55, 58],
Glycogen synthesis
Alanine aminotransferase
Ammonia and aminoacid utilization
Urea synthesis, Aminoacid degradation CPS1, OTC, ASS, Arg, TAT, SerDH, Alanine aminotransferase Glutamine synthesis GS [10, 11, 55, 5961]
Aspartate aminotranferase
Xenobiotic metabolism
   Monooxygenation, Glucuronidation Cytochrome P450 monooxygenases [11, 55]
GST, sulfotransferases
  1. Abbreviations: CPI carnitine palmitoyltransferase I, ACC acetyl-CoA carboxylase, ACL ATP citrate lyase, FAS fatty acid synthase, G6Pas glucose-6-phosphatase, FBPas fructose-1,6-bisphosphatase, PEPCK phosphoenolpyruvate carboxykinase, GK glucokinase, PK L pyruvate kinase isoenzyme L, CPS1 carbamoylphosphate synthetase, OTC ornithine carbamoyl transferas, ASS arginine succinate synthetase, Arg1 Arginase 1, TAT tyrosine aminotransferase, SerDH serine dehydratase, GS glutamine synthase, GST glutathione S-transferase