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Table 3 The variable importance in the projection (VIP) valuesa and p values of identified metabolites between MHPO and MUCO groups in the discovery stage (VIP > 1, p-value < 0.05)

From: Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals

Metabolites VIP value P-value Metabolites VIP value P-value
Hexoses 1.87725 0.000157* C4:1 1.55489 0.010843
Tyrosine 1.95689 0.000507* C10:2 1.55734 0.012379
Leucine 2.00158 0.000669* C6(C4:1-DC) 1.16246 0.015448
Isoleucine 1.91919 0.000881* C0 1.26561 0.015564
Valine 1.93636 0.000881* C6:1 1.36558 0.018482
Phenylalanine 1.78606 0.003197* C16-OH 1.61161 0.024043
Lysine 1.51144 0.008151 C5-DC(C6-OH) 1.30387 0.027184
Histidine 1.55651 0.015564 C16 1.20206 0.033822
Methionine 1.55505 0.015526 C10:1 1.2771 0.041174
Alanine 1.47744 0.019110 C3-DC(C4-OH) 1.0104 0.049025
Proline 1.37059 0.023342 PC aa C40:2 1.30675 0.041250
Glutamine 1.42081 0.041250 PC ae C38:4 1.37446 0.019110
alphaAAA 1.72871 0.001152* PC ae C342 1.11563 0.025692
MetSO 1.57108 0.007564* PC ae C36:4 1.18682 0.028366
Kynurenine 1.41756 0.028366 PC ae C38:5 1.25626 0.034294
Sarcosine 1.3291 0.028366 PC ae C42:0 1.13183 0.041250
C3 1.53624 0.003299* PC ae C36:3 1.15062 0.049366
C4 1.45988 0.006502 PC ae C38:6 1.15541 0.049366
C5:1 1.45929 0.008849 lysoPC a C28:1 1.22246 0.049366
C5 1.44608 0.009056    
  1. aHigher VIP values indicate a stronger influence of the metabolite in distinguishing different groups. Kruskal-Wallis test set to p < 0.05. MUCO metabolically unhealthy central obesity; MHPO metabolically healthy peripheral obesity; Hexose (mainly glucose); alphaAAA, alpha-Aminoadipic acid; Met-SO, Methioninesulfoxide. Asterisk (*) marks statistical significance after Bonferroni correction