Interactions with the MC4R rs17782313 variant, mental stress and energy intake and the risk of obesity in Genome Epidemiology Study

Nutrition & Metabolism

Table 4 Association between MC4R rs17782313 polymorphism and obesity according to energy and fat intake

		TT	CT	CC	Interaction^d
Energy intake	Higher than EER	1^a	1.022 (1.005–1.039)*^,b	1.053 (1.019–1.087)**	0.0594
Energy intake	Lower than EER	1	1.002 (0.945–1.062)	1.064 (0.961–1.177)	0.0594
Fat intake	Higher fat (≥14 %)	1	1.015 (0.989–1.042)^b	1.052 (1.003–1.103)*	0.4531
Fat intake	Lower fat (<14 %)	1	1.021 (0.996–1.047)	1.045 (0.994–1.099)	0.4531
Stress status	High stress	1	1.012 (0.983–1.042)^c	1.112 (1.054–1.173)***	0.0359
Stress status	Low stress	1	1.027 (1.006–1.049)*	1.020 (0.978–1.062)	0.0359

^*Significantly different from reference group at P = 0.05. ^** P = 0.01, ^*** P = 0.001
^aReference group
^bOdds ratio and 95 % confidence intervals after adjusted for age, gender, residence area, total activity and smoking status
^cOdds ratio and 95 % confidence intervals after adjusted for age, gender, residence area, daily energy intake, total activity and smoking status
^d P value for the interaction term between MC4R polymorphism and energy intake, fat intake or stress status in the logistic regression model