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Table 1 Clinical and biochemical characteristics of the participants from the CURES study

From: Interaction between FTO gene variants and lifestyle factors on metabolic traits in an Asian Indian population

Clinical and biochemical parameters Type 2 diabetic subjects (T2DM) Normal glucose tolerance subjects (NGT) P value*
Men Women Men Women
(N = 407) (N = 327) (N = 509) (N = 375)
Age (yrs) 49.59 ± 10.49 50.74 ± 11.47 36.25 ± 11.21 36.54 ± 11.70 <0.0001
BMI (Kg/m2) 26.33 ± 4.37 24.49 ± 3.94 23.57 ± 5.09 22.74 ± 4.25 <0.0001
WC (cm) 90.08 ± 9.95 92.11 ± 9.93 80.76 ± 12.43 83.81 ± 11.85 <0.0001
Obese cases (%) 243.00 (60.00) 139.00 (42.50) 179.00 (35.20) 110.00 (29.40) <0.0001
Fasting plasma glucose (mg/dl) 165.42 ± 73.22 155.71 ± 61.52 84.47 ± 8.36 84.71 ± 8.14 <0.0001
Fasting serum insulin (μIU/ml) 12.68 ± 7.62 10.61 ± 6.95 8.48 ± 5.98 7.48 ± 4.88 <0.0001
Systolic blood pressure (mmHg) 129.91 ± 21.82 128.11 ± 21.72 114.25 ± 17.54 116.25 ± 15.60 <0.0001
Diastolic blood pressure (mmHg) 76.54 ± 12.07 78.03 ± 11.73 71.25 ± 11.38 74.28 ± 11.52 <0.0001
Total serum cholesterol (mg/dl) 209.21 ± 43.71 193.66 ± 39.34 173.35 ± 35.15 171.99 ± 35.91 <0.0001
Fasting serum triglycerides (mg/dl) 179.10 ± 118.48 189.25 ± 145.81 100.88 ± 53.71 123.67 ± 70.97 <0.0001
HDL cholesterol (mg/dl) 43.68 ± 9.76 39.05 ± 8.66 45.47 ± 9.80 40.10 ± 9.49 <0.0001
LDL cholesterol (mg/dl) 131.76 ± 36.19 120.93 ± 33.66 107.90 ± 30.17 107.47 ± 29.78 <0.0001
Glycated Haemoglobin (HbA1c) 8.65 ± 2.39 8.76 ± 2.32 5.54 ± 0.50 5.55 ± 0.49 <0.0001
PAL [Sedentary (%); Moderate (%); Vigorous (%)] 263 (77.10); 76 (22.30); 2 (0.60) 193 (46.80); 60 (20.10); 45 (15.10) 362 (80.80); 80 (17.90); 6 (1.30) 240 (64.70); 112 (30.20); 19 (5.10) 0.001
Total Carbohydrate energy % 65.50 ± 5.43 64.08 ± 6.27 64.60 ± 5.89 63.09 ± 6.84 0.003
Fat energy % 23.23 ± 4.51 23.58 ± 4.76 23.81 ± 4.79 23.88 ± 4.65 0.05
Protein energy % 11.47 ± 1.20 11.43 ± 1.25 11.25 ± 1.12 11.35 ± 1.25 0.009
Energy adjusted glycemic index 62.76 ± 0.14 62.16 ± 0.18 62.94 ± 0.12 62.65 ± 0.14 0.02
Energy adjusted glycemic load 233.52 ± 1.64 226.12 ± 2.40 231.63 ± 1.74 224.32 ± 0.36 0.41
Dietary fibre (g) 28.62 ± 0.54 34.91 ± 0.69 29.84 ± 0.42 35.73 ± 0.56 0.10
  1. NGT, Normal Glucose Tolerance; BMI, Body Mass Index; WC, Waist Circumference; HDL, High Density Lipoproteins; LDL, Low Density Lipoproteins; PAL, Physical Activity Level
  2. Data shown are represented as means ± SD, wherever appropriate
  3. *P values for the differences in the means/proportions between Type 2 diabetes cases and NGT participants