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Table 2 Hazard ratios of lipid measures for predicting first cardiovascular disease events among participants without prevalent CVD (n = 5054); Tehran Lipid and Glucose Study (TLGS) (2001–2012)a

From: Divergent pathway of lipid profile components for cardiovascular disease and mortality events: Results of over a decade follow-up among Iranian population

  Model 1 Model 2
SD (mmol/L) HR (95 % CI) p-value HR (95 % CI) p-value
Men      
 TC 1.10 1.34(1.22-1.47) <0.001 1.3(1.18-1.43) <0.001
 LDL-C 0.93 1.37(1.25-1.51) <0.001 1.33(1.2-1.46) <0.001
 HDL-C 0.25 0.88(0.79-0.98) 0.021 0.94(0.84-1.04) 0.24
 Non-HDL-C 1.11 1.37(1.25-1.5) <0.001 1.32(1.20-1.45) <0.001
 ln-TGs 0.57 1.20(1.09-1.3) <0.001 1.1(1.0-1.21) 0.05
 TC/HDL-C 1.85 1.10(1.13-1.28) <0.001 1.17(1.09-1.25) <0.001
 ln-TGs/HDL-C 0.7 1.2(1.1-1.31) <0.001 1.1(1.0-1.21) 0.056
Women      
 TC 1.24 1.30(1.18-1.43) <0.001 1.21(1.1-1.34) <0.001
 LDL-C 1.05 1.30(1.19-1.43) <0.001 1.22(1.11-1.35) <0.001
 HDL-C 0.29 0.87(0.78-0.98) 0.02 0.91(0.82-1.02) 0.11
 Non-HDL-C 1.23 1.32(1.20-1.45) <0.001 1.23(1.12-1.36) <0.001
 ln-TGs 0.51 1.42(1.27-1.58) <0.001 1.24(1.1-1.4) <0.001
 TC/HDL-C 1.69 1.33(1.21-1.46) <0.001 1.26(1.13-1.4) <0.001
 ln-TGs/HDL-C 0.65 1.38(1.23-1.54) <0.001 1.22(1.09-1.38) 0.001
Total      
 TC 1.21 1.33(1.24-1.42) <0.001 1.26(1.18-1.35) <0.001
 LDL-C 1.01 1.34(1.26-1.43) <0.001 1.27(1.19-1.36) <0.001
 HDL-C 0.28 0.88(0.81-0.95) 0.001 0.93(0.86-1.007) 0.07
 Non-HDL-C 1.19 1.35(1.26-1.44) <0.001 1.22(1.14-1.30) <0.001
 ln-TGs 0.53 1.28(1.20-1.37) <0.001 1.15(1.07-1.24) <0.001
 TC/HDL-C 1.78 1.24(1.18-1.30) <0.001 1.18(1.12-1.25) <0.001
 ln-TGs/HDL-C 0.67 1.27(1.18-1.36) <0.001 1.14(1.06-1.23) <0.001
  1. Model 1: Lipid profile + gender (for total population); model 2 = model 1 + blood pressure status (i.e. normotension, prehypertension and hypertension status), glucose tolerance status (normal glucose tolerance, prediabetes and diabetes), education status, low physical activity, current smoker, lipid lowering drugs and body mass index
  2. aHazard ratios (HR) indicate the increased risk for every 1-SD increase of each lipid parameter
  3. CVD cardiovascular disease, SD standard deviation, TC total cholesterol, LDL-C low density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol, ln-TGs logarithm-transformed triglycerides, CI confidence interval