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Table 3 Hazard ratios for predicting first cardiovascular disease based on to lipid profile tertiles of participants without prevalent CVD (n = 5054); Tehran Lipid and Glucose Study (TLGS) (2001–2012)

From: Divergent pathway of lipid profile components for cardiovascular disease and mortality events: Results of over a decade follow-up among Iranian population

  Model 1    Model 2    
Tertiles of variables Tertiles of variables P for trend*
1 2 3 1 2 3  
Men        
 TC, mmol/L Reference 1.28(1.02-1.6) 1.96(1.56-2.46) Reference 1.28(1.02-1.61) 1.84(1.46-2.32) <0.001
 LDL-C, mmol/L Reference 1.36(1.08-1.71) 1.88(1.49-2.36) Reference 1.38(1.09-1.74) 1.76(1.39-2.23) <0.001
 HDL-C, mmol/L Reference 0.90(0.72-1.12) 0.81(0.64-1.02) Reference 0.94(0.75-1.17) 0.92(0.72-1.31) 0.44
 Non-HDL-C, mmol/L Reference 1.35 (1.07-1.7) 1.86 (1.48-2.33) Reference 1.35 (1.07-1.70) 1.72 (1.36-2.18) <0.001
 TGs, mmol/L Reference 1.24(0.98-1.57) 1.55(1.24-1.95) Reference 1.1(0.87-1.4) 1.25(0.98-1.60) 0.07
 TC/HDL-C Reference 1.35(1.05-1.73) 1.74(1.37-2.21) Reference 1.25(0.97-1.61) 1.54(1.2-1.98) 0.001
 TGs/HDL-C Reference 1.32(1.03-1.68) 1.63(1.29-2.06) Reference 1.20(0.93-1.54) 1.34(1.04-1.72) 0.02
Women        
 TC, mmol/L Reference 1.72(1.18-2.52) 2.23(1.57-3.18) Reference 1.64(1.20-2.40) 1.98(1.39-2.83) <0.001
 LDL-C, mmol/L Reference 1.89(1.32-2.72) 2.36(1.67-3.32) Reference 1.79(1.25-2.58) 2.09(1.48-2.96) <0.001
 HDL-C, mmol/L Reference 1.14(0.84-1.54) 0.87(0.66-1.14) Reference 1.19(0.88-1.61) 0.95(0.72-1.26) 0.49
 Non-HDL-C, mmol/L Reference 1.71 (1.19-2.45) 2.39 (1.7-3.36) Reference 1.57 (1.09-2.27) 2.09 (1.48-2.95) <0.001
 TGs, mmol/L Reference 1.39(1.02-1.89) 2.09(1.57-2.79) Reference 1.17(0.85-1.60) 1.5(1.1-2.03) 0.006
 TC/HDL-C Reference 1.56(1.17-2.07) 2.08(1.57-2.74) Reference 1.39(1.04-1.86) 1.78(1.34-2.36) <0.001
 TGs/HDL-C Reference 1.45(1.1-1.91) 1.75(1.33-2.31) Reference 1.23(0.93-1.62) 1.33(1.0-1.77) 0.05
Total        
 TC, mmol/L Reference 1.39(1.15-1.68) 2.02(1.68-2.43) Reference 1.36(1.12-1.66) 1.85(1.53-2.23) <0.001
 LDL-C, mmol/L Reference 1.5(1.23-1.81) 2.01(1.67-2.42) Reference 1.48(1.22-1.79) 1.84(1.52-2.22) <0.001
 HDL-C, mmol/L Reference 0.97(0.82-1.16) 0.82(0.69-0.97) Reference 1.01(0.85-1.21) 0.92(0.77-1.09) 0.34
 Non-HDL-C Reference 1.44(1.19-1.75) 2.03(1.69-2.44) Reference 1.39(1.15-1.70) 1.82(1.51-2.20) <0.001
 TGs, mmol/L Reference 1.29(1.07-1.55) 1.77(1.48-2.11) Reference 1.12(0.92-1.35) 1.35(1.12-1.63) 0.001
 TC/HDL-C Reference 1.44(1.19-1.73) 1.89(1.58-2.26) Reference 1.31(1.08-1.58) 1.63(1.35-1.96) <0.001
 TGs/HDL-C Reference 1.37(1.15-1.65) 1.69(1.42-2.02) Reference 1.21(1.001-1.45) 1.33(1.11-1.61) 0.003
  1. Model 1: lipid profile tertiles + gender (for total population); model 2 = model 1 + blood pressure status (i.e. normotension, prehypertension and hypertension status), glucose tolerance status (normal glucose tolerance, prediabetes and diabetes), education status, low physical activity, current smoker, lipid lowering drugs and body mass index
  2. CVD cardiovascular disease, TC total cholesterol, LDL-C low density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol, TGs triglycerides, CI confidence interval. *P-values were calculated using age scale Cox proportional hazards regression models