Table 3 Hazard ratios for predicting first cardiovascular disease based on to lipid profile tertiles of participants without prevalent CVD (n = 5054); Tehran Lipid and Glucose Study (TLGS) (2001–2012)

Men

 TC, mmol/L

Reference

1.28(1.02-1.6)

1.96(1.56-2.46)

Reference

1.28(1.02-1.61)

1.84(1.46-2.32)

<0.001

 LDL-C, mmol/L

Reference

1.36(1.08-1.71)

1.88(1.49-2.36)

Reference

1.38(1.09-1.74)

1.76(1.39-2.23)

<0.001

 HDL-C, mmol/L

Reference

0.90(0.72-1.12)

0.81(0.64-1.02)

Reference

0.94(0.75-1.17)

0.92(0.72-1.31)

0.44

 Non-HDL-C, mmol/L

Reference

1.35 (1.07-1.7)

1.86 (1.48-2.33)

Reference

1.35 (1.07-1.70)

1.72 (1.36-2.18)

<0.001

 TGs, mmol/L

Reference

1.24(0.98-1.57)

1.55(1.24-1.95)

Reference

1.1(0.87-1.4)

1.25(0.98-1.60)

0.07

 TC/HDL-C

Reference

1.35(1.05-1.73)

1.74(1.37-2.21)

Reference

1.25(0.97-1.61)

1.54(1.2-1.98)

0.001

 TGs/HDL-C

Reference

1.32(1.03-1.68)

1.63(1.29-2.06)

Reference

1.20(0.93-1.54)

1.34(1.04-1.72)

0.02

Women

 TC, mmol/L

Reference

1.72(1.18-2.52)

2.23(1.57-3.18)

Reference

1.64(1.20-2.40)

1.98(1.39-2.83)

<0.001

 LDL-C, mmol/L

Reference

1.89(1.32-2.72)

2.36(1.67-3.32)

Reference

1.79(1.25-2.58)

2.09(1.48-2.96)

<0.001

 HDL-C, mmol/L

Reference

1.14(0.84-1.54)

0.87(0.66-1.14)

Reference

1.19(0.88-1.61)

0.95(0.72-1.26)

0.49

 Non-HDL-C, mmol/L

Reference

1.71 (1.19-2.45)

2.39 (1.7-3.36)

Reference

1.57 (1.09-2.27)

2.09 (1.48-2.95)

<0.001

 TGs, mmol/L

Reference

1.39(1.02-1.89)

2.09(1.57-2.79)

Reference

1.17(0.85-1.60)

1.5(1.1-2.03)

0.006

 TC/HDL-C

Reference

1.56(1.17-2.07)

2.08(1.57-2.74)

Reference

1.39(1.04-1.86)

1.78(1.34-2.36)

<0.001

 TGs/HDL-C

Reference

1.45(1.1-1.91)

1.75(1.33-2.31)

Reference

1.23(0.93-1.62)

1.33(1.0-1.77)

0.05

Total

 TC, mmol/L

Reference

1.39(1.15-1.68)

2.02(1.68-2.43)

Reference

1.36(1.12-1.66)

1.85(1.53-2.23)

<0.001

 LDL-C, mmol/L

Reference

1.5(1.23-1.81)

2.01(1.67-2.42)

Reference

1.48(1.22-1.79)

1.84(1.52-2.22)

<0.001

 HDL-C, mmol/L

Reference

0.97(0.82-1.16)

0.82(0.69-0.97)

Reference

1.01(0.85-1.21)

0.92(0.77-1.09)

0.34

 Non-HDL-C

Reference

1.44(1.19-1.75)

2.03(1.69-2.44)

Reference

1.39(1.15-1.70)

1.82(1.51-2.20)

<0.001

 TGs, mmol/L

Reference

1.29(1.07-1.55)

1.77(1.48-2.11)

Reference

1.12(0.92-1.35)

1.35(1.12-1.63)

0.001

 TC/HDL-C

Reference

1.44(1.19-1.73)

1.89(1.58-2.26)

Reference

1.31(1.08-1.58)

1.63(1.35-1.96)

<0.001

 TGs/HDL-C

Reference

1.37(1.15-1.65)

1.69(1.42-2.02)

Reference

1.21(1.001-1.45)

1.33(1.11-1.61)

0.003