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Fig. 4 | Nutrition & Metabolism

Fig. 4

From: Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia

Fig. 4

Glucagon secretion from αZnT8Tg islets is impaired in vitro. Isolated islets were incubated at 1 mM or 17 mM glucose for 1 h. Released glucagon was measured using an HTRF assay. Transgenic islets secreted significantly less glucagon compared to control when incubated at 1 mM glucose. Data are mean ± SEM, n = 4 separate experiments involving islets from 3 to 4 mice per genotype, *P < 0.05

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