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Table 2 Circulating lipids, relative liver weight and biochemical markers after 16 weeks on diets

From: High-fat but not sucrose intake is essential for induction of dyslipidemia and non-alcoholic steatohepatitis in guinea pigs

 

Control

vHS

HF

HFHS

HFvHS

VLDL-C (mM) a

0.19 (0.11–0.33)

0.18 (0.11–0.30)

1.01 (0.60–1.72) ** ###

0.89 (0.52–1.51) ** ##

0.68 (0.40–1.16) * #

LDL-C (mM) a

1.22 (0.92–1.62)

1.55 (1.17–2.06)

9.04 (6.81–12.0) **** ####

7.86 (5.90–10.4) **** ####

6.54 (4.93–8.68) **** ####

HDL-C (mM) a

0.04 (0.03–0.06)

0.04 (0.03–0.06)

0.07 (0.04–0.10)

0.10 (0.06–0.15)

0.09 (0.06–0.15)

FFA (mM)

0.77 ± 0.23

0.68 ± 0.16

0.50 ± 0.15

0.51 ± 0.09

0.52 ± 0.21

SAA (μg/mL) a

89.4 (47.5–168)

182 (91.8–359)

14.3 (7.22–28.3) ** ####

22.5 (10.7–47.5) ##

10.8 (5.77–20.4) *** ####

% Liver weight a

2.16 (1.92–2.43)

2.29 (2.03–2.57)

4.72 (4.19–5.31) **** ####

4.63 (4.11–5.21) **** ####

4.30 (3.82–4.84) **** ####

ALT (U/L) a

43.1 (34.1–54.7)

32.4 (25.6–41.1)

92.5 (73.0–117) *** ####

106 (83.8–128) **** ####

98.1 (76.0–127)*** ####

AST (U/L) a

67.0 (47.3–95.2)

51.5 (36.3–73.1)

403 (284–572) **** ####

450 (317–639) **** ####

323 (221–471) **** ####

ALP (U/L)

70.3 ± 5.53

60.7 ± 18.5

59.0 ± 14.6

53.9 ± 9.19

51.9 ± 17.3

  1. n = 7. Mean with SD. Compared to control **** p < 0.0001*** p < 0.001 ** p < 0.01 * p < 0.05. Compared to vHS #### p < 0.0001### p < 0.001 ## p < 0.01 # p < 0.05
  2. a Data analysis performed on log10 transformed data, presented as geometric means with 95 % confidence interval