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Table 3 Circulating lipids, relative liver weight and biochemical markers after 25 weeks on diets

From: High-fat but not sucrose intake is essential for induction of dyslipidemia and non-alcoholic steatohepatitis in guinea pigs

 

Control

vHS

HF

HFHS

HFvHS

VLDL-C (mM) a

0.12 (0.07–0.20)

0.13 (0.08–0.23)

1.02 (0.60–1.74) **** ####

1.38 (0.81–2.35) **** ####

0.89 (0.52–1.51) **** ###

LDL-C (mM) a

0.99 (0.74–1.31)

1.15 (0.87–1.52)

7.74 (5.83–10.3) **** ####

7.83 (5.90–10.4) **** ####

7.38 (5.56–9.79) **** ####

HDL-C (mM) a

0.03 (0.02–0.05)

0.04 (0.02–0.06)

0.06 (0.04–0.10)

0.08 (0.05–0.12)

0.07 (0.04–0.10)

FFA (mM)

0.48 ± 0.22

0.61 ± 0.12

0.58 ± 0.13

0.64 ± 0.13

0.43 ± 0.17

SAA (μg/mL) a

46.6 (24.8–87.7)

88.3 (46.9–166)

20.9 (10.6–41.3)

48.1 (24.3–95.2)

12.3 (6.56–23.2) ##

% Liver weight a

2.07 (1.84–2.32)

2.55 (2.27–2.87)

4.90 (4.35–5.51) **** ####

5.19 (4.61–5.84) **** ####

4.97 (4.42–5.59)**** ####

ALT (U/L) a

37.0 (29.2–46.9)

30.2 (23.8–38.2)

77.7 (61.3–98.3) ** ####

101 (79.7–128) **** ####

86.4 (68.3–109) *** ####

AST (U/L) a

43.6 (30.7–61.8)

43.7 (30.8–62.0)

259 (183–368) **** ####

428 (302–607) **** ####

445 (314–631) **** ####

ALP (U/L)

60.1 ± 4.88

59.6 ± 13.1

45.9 ± 5.18

43.3 ± 1.70

47.0 ± 7.05

  1. n = 7. Mean with SD. Compared to control **** p < 0.0001*** p < 0.001 ** p < 0.01. Compared to vHS #### p < 0.0001 ### p < 0.001
  2. a Data analysis performed on log10 transformed data, presented as geometric means with 95 % confidence interval