2-amino-1-methyl-6-phenylimidazo(4,5-b) pyridine (PhIP) induces gene expression changes in JAK/STAT and MAPK pathways related to inflammation, diabetes and cancer

Table 2 Differential expression of genes in h-MSC-derived adipocytes exposed to PhIP

Gene Symbol	Accession	Ave Expression	FC	P.Value	adj.P.Val
ANGPTL2^a	NM_012098.2	8.578	1.88	6.19E-07	0.59E-04
EGR1^a	NM_001964.2	8.750	-2.93	2.65E-10	1.25E-05
FOS^a	NM_005252.2	7.120	-1.95	2.57E-08	0.61E-05
IBP5^a	NM_000599.2	8.550	1.91	2.45E-06	0.014
CIDEA	NM_001279.2	6.697	1.49	3.24E-07	0.39E-04
PALM	NM_002579.2	8.575	1.63	4.06E-06	0.018
PSAT1	NM_021154.3	8.614	-1.62	4.26E-06	0.018
CD14	NM_001040021.1	7.650	1.58	1.93E-05	0.05

Differentially expressed genes in hMSC derived adipocyte exposed to 5 nM PhiP for 72 h, adjusted for multiple comparisons, significant at the p = 0.05 level
^aReceptor ligands, transcriptional factors and/or binding proteins that are significant and are controlled by the STAT3 transcriptional factor in the gene-gene interaction and pathway analyses (see Figs. 4 and 5)

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