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Table 3 The effects of high calorie diet (± metformin) on gene expression in maternal and fetal livers

From: The effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolism

Maternal livers Fetal Livers
Gene NORM mean (±SD) HCAL mean (±SD) HCAL + MET mean (±SD) NORM mean (±SD) HCAL mean (±SD) HCAL + MET mean (±SD)
Chrebp 1.0 (±0.33) 0.9 (±0.19) 1.1 (±0.41) 1.0 (±0.25) 1.1 (±0.34) 0.9 (±0.46)
D5d 1.0 (±0.36) 1.2 (±0.23) 1.4 (±0.27) 1.0 (±0.34) 1.5 (±0.44)a* 1.4 (±0.34)
D6d 1.0 (±0.49) 1.1 (±0.33) 1.5 (±0.26) 1.0 (±0.31) 1.5 (±0.23)a*** 1.6 (±0.26)
D9d (Scd1) 1.0 (±0.68) 1.2 (±0.35) 1.3 (±0.33) 1.0 (±0.33) 1.4 (±0.37)a* 1.2 (±0.28)
Elovl2 1.0 (±0.39) 0.9 (±0.24) 0.8 (±0.13) 1.0 (±0.23) 1.1 (±0.30) 1.0 (±0.32)
Elovl5 1.0 (±0.14) 1.0 (±0.24) 1.1 (±0.06) 1.0 (±0.12) 1.5 (±0.86) 1.1 (±0.18)
Elovl6 1.0 (±0.37) 0.8 (±0.26) 1.0 (±0.43) 1.0 (±0.15) 1.1 (±0.16) 1.3 (±0.25)
Fasn 1.0 (±0.46) 1.0 (±0.47) 1.1 (±0.39) 1.0 (±0.18) 1.5 (±0.28)a*** 1.6 (±0.37)
Lxrα 1.0 (±0.13) 1.0 (±0.09) 1.1 (±0.14) 1.0 (±0.13) 1.2 (±0.30)a** 1.3 (±0.30)
Lxrβ 1.0 (±0.42) 1.0 (±0.11) 1.0 (±0.13) 1.0 (±0.13) 1.0 (±0.14) 1.0 (±0.13)
Srebf1 1.0 (±0.29) 1.8 (±0.36)a*** 1.7 (±0.38) 1.0 (±0.23) 1.3 (±0.40) 1.2 (±0.19)
  1. NORM normal diet, HCAL high calorie diet, MET metformin, SD standard deviation
  2. aNORM vs. HCAL; *p = <0.05; **p < 0.01, ***p < 0.001
  3. Data are presented as relative mRNA expression (mean ± SD), with the normal-fed group set to 1.0
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Nutrition & Metabolism

ISSN: 1743-7075

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