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Table 3 The effects of high calorie diet (± metformin) on gene expression in maternal and fetal livers

From: The effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolism

Maternal livers

Fetal Livers

Gene

NORM mean (±SD)

HCAL mean (±SD)

HCAL + MET mean (±SD)

NORM mean (±SD)

HCAL mean (±SD)

HCAL + MET mean (±SD)

Chrebp

1.0 (±0.33)

0.9 (±0.19)

1.1 (±0.41)

1.0 (±0.25)

1.1 (±0.34)

0.9 (±0.46)

D5d

1.0 (±0.36)

1.2 (±0.23)

1.4 (±0.27)

1.0 (±0.34)

1.5 (±0.44)a*

1.4 (±0.34)

D6d

1.0 (±0.49)

1.1 (±0.33)

1.5 (±0.26)

1.0 (±0.31)

1.5 (±0.23)a***

1.6 (±0.26)

D9d (Scd1)

1.0 (±0.68)

1.2 (±0.35)

1.3 (±0.33)

1.0 (±0.33)

1.4 (±0.37)a*

1.2 (±0.28)

Elovl2

1.0 (±0.39)

0.9 (±0.24)

0.8 (±0.13)

1.0 (±0.23)

1.1 (±0.30)

1.0 (±0.32)

Elovl5

1.0 (±0.14)

1.0 (±0.24)

1.1 (±0.06)

1.0 (±0.12)

1.5 (±0.86)

1.1 (±0.18)

Elovl6

1.0 (±0.37)

0.8 (±0.26)

1.0 (±0.43)

1.0 (±0.15)

1.1 (±0.16)

1.3 (±0.25)

Fasn

1.0 (±0.46)

1.0 (±0.47)

1.1 (±0.39)

1.0 (±0.18)

1.5 (±0.28)a***

1.6 (±0.37)

Lxrα

1.0 (±0.13)

1.0 (±0.09)

1.1 (±0.14)

1.0 (±0.13)

1.2 (±0.30)a**

1.3 (±0.30)

Lxrβ

1.0 (±0.42)

1.0 (±0.11)

1.0 (±0.13)

1.0 (±0.13)

1.0 (±0.14)

1.0 (±0.13)

Srebf1

1.0 (±0.29)

1.8 (±0.36)a***

1.7 (±0.38)

1.0 (±0.23)

1.3 (±0.40)

1.2 (±0.19)

  1. NORM normal diet, HCAL high calorie diet, MET metformin, SD standard deviation
  2. aNORM vs. HCAL; *p = <0.05; **p < 0.01, ***p < 0.001
  3. Data are presented as relative mRNA expression (mean ± SD), with the normal-fed group set to 1.0