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Table 4 HCAL diet (±metformin) exposure alters FA profiles of fetal livers

From: The effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolism

Fatty acid NORM mean (±SD) HCAL mean (±SD) HCAL + MET mean (±SD)
SFA 14.0 2.1 (±0.18) 2.2 (±0.27) 2.1 (±0.23)
16.0 23.9 (±0.96) 25.6 (±1.57) 25.4 (±1.94)
18.0 7.18 (±0.73) 8.8 (±0.87)a*** 9.2 (±0.76)
MUFA 16.1n7 4.3 (±0.45) 4.6 (±0.46) 3.9 (±0.29)
18.1n9 34.2 (±1.56) 38.8 (±2.08)a** 35.9 (±2.26)b**
18.1n7 3.6 (±0.28) 4.4 (±0.20)a*** 4.2 (±0.17)
PUFA 18.2n6 14.4 (±2.1) 8.8 (±1.70)a*** 10.1 (±0.92)
18.3n6 0.5 (±0.26) 0.4 (±0.21) 0.22 (±0.28)
20.4n6 2.2 (±0.69) 1.4 (±0.43)a* 1.7 (±0.31)
22.6n3 6.8 (±1.02) 5.0 (±1.76)a* 7.0 (±1.21)b*
  1. NORM normal diet, HCAL high calorie diet, MET metformin, SD standard deviation, SFA saturated fatty acids, MUFA monounsaturated fatty acids, PUFA polyunsaturated fatty acids
  2. aNORM vs. HCAL, bHCAL vs. HCAL + MET; *p < 0.05, **p < 0.01, ***p < 0.001
  3. Data are expressed as mean ± SD (mg/100 mg)