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Table 5 Effects of maternal HCAL diet (±metformin) on fetal brain FA profiles

From: The effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolism

Fatty acid NORM mean (±SD) HCAL mean (±SD) HCAL + MET mean (±SD)
SFA 14.0 1.9 (±0.08) 2.0 (±0.05) 2.0 (±0.23)
16.0 33.4 (±0.89) 33.6 (±0.93) 32.8 (±0.27)
18.0 17.8 (±0.81) 17.5 (±0.52) 16.9 (±0.30)
MUFA 16.1n7 2.2 (±0.21) 2.2 (±0.10) 2.3 (±0.12)
18.1n9 13.6 (±0.56) 13.9 (±0.30) 14.3 (±0.39)
18.1n7 3.9 (±0.19) 3.9 (±0.26) 4.0 (±0.21)
PUFA 20.4n6 13.2 (±0.42) 12.5 (±0.35)a* 13.0 (±0.41)
22.4n6 3.2 (±0.12) 2.9 (±0.03)a** 3.0 (±0.17)
22.5n6 2.9 (±0.24) 2.3 (±0.22)a** 2.7 (±0.22)b*
22.6n3 7.0 (±0.75) 8.6 (±1.53)a* 8.0 (±0.35)
  1. NORM normal diet, HCAL high calorie diet, MET metformin, SD standard deviation, SFA saturated fatty acids, MUFA monounsaturated fatty acids, PUFA polyunsaturated fatty acids
  2. aNORM vs. HCAL,b HCAL vs. HCAL + MET; *p < 0.05, **p < 0.01
  3. Data are expressed as mean ± SD (mg/100 mg)