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Table 6 The effects of HCAL diet (± metformin) on gene expression in fetal brains

From: The effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolism

Gene NORM mean (±SD) HCAL mean (±SD) HCAL + MET mean (±SD)
Chrebp ND ND ND
D5d 1.0 (±0.14) 0.9 (±0.13) 1.0 (±0.19)
D6d 1.0 (±0.06) 0.9 (±0.12) 1.1 (±0.09)
D9d (Scd1) 1.0 (±0.06) 0.9 (±0.11)a*** 0.8 (±0.05)
Elovl2 1.0 (±0.10) 1.4 (±0.42) 1.5 (±0.08)
Elovl5 1.0 (±0.20) 1.0 (±0.14) 1.0 (±0.10)
Elovl6 1.0 (±0.15) 0.9 (±0.17) 1.1 (±0.16)
Fasn 1.0 (±0.13) 1.0 (±0.07) 1.0 (±0.10)
Lxrα 1.0 (±0.01) 1.2 (±0.07) 1.4 (±0.29)
Lxrβ 1.0 (±0.19) 0.9 (±0.09) 0.8 (±0.22)
Srebf1 1.0 (±0.14) 1.1 (±0.23) 1.0 (±0.27)
  1. NORM normal diet, HCAL high calorie diet, MET metformin, SD standard deviation
  2. aNORM vs. HCAL; ***p < 0.001
  3. Data are presented as relative mRNA expression (mean ± SD), with the normal-fed group set to 1.0