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Fig. 5 | Nutrition & Metabolism

Fig. 5

From: Fatty acids stimulate insulin secretion from human pancreatic islets at fasting glucose concentrations via mitochondria-dependent and -independent mechanisms

Fig. 5

Contribution of the fatty acid metabolism and FFAR1/GPR40 signaling to FFA-induced insulin secretion in the absence of glucose. Human islets were incubated with or without palmitate (PA) (a-d) or oleate (OA) (e-h) for 20 min in the absence of glucose. a and e Representative graphs of dynamic insulin secretion from perifused islets is shown. Fatty acids were added as indicated. b, c, d, f, g and h) Total, first-phase and second-phase of FFA-stimulated insulin secretion during perifusion was expressed as fold control. Results are means ± SEM of 3 donors. *P < 0.05 vs control, #P < 0.05 vs fatty acid alone

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