Gene symbol/GenBank accession/Gene ID | Entrez gene name | HFrD/Chow (Fold-change) | HFrD-NDGA/HFrD (Fold-change) |
---|---|---|---|
 | Fatty Acid Transport |  |  |
Slc27a1 Acc: NM_053580.2 ID: 94172 | Soluble carrier family 27 (fatty acid transporter), member 1 (FATP1) | 0.817382 (p = 0.050249) | 1.085686 (p = 0.548792) |
Slc27a2 Acc: NM_031736.1 ID: 65192 | Soluble carrier family 27 (fatty acid transporter), member 2 (FATP2) | 1.276261↑ (p = 0.017602) | 1.071673 (p = 0.458057) |
 | Acyl-CoA Synthetases |  |  |
Acsl1 Acc: NM_012820.1 ID: 25288 | Acyl-CoA synthetase long-chain family member 1 (ACS, Acas, COAA, Facl2) | 1.058003 (p = 0.59888) | 1.286236↑ (p = 0.015343) |
Acsl4 Acc: NM_053623.1 ID: 113976 | Acyl-CoA synthetase long-chain family member 4 (ACS4, Facl4) | 1.673512↑ (p = 0.000004) | 0.697139↓ (p = 0.001224) |
Acsm3 Acc: NM_033231.1 ID: 24763 | Acyl-CoA synthetase medium-chain family member 3 (Sa, Sah) | 0.458851↓ (p = 0.000004) | 1.583156↑ (p = 0.000039) |
Acss2 Acc: NM_001107793.1 ID: 311569 | Acyl-CoA synthetase short chain family member 2 (Acss2) | 1.640823↑ (p = 5.92E-09) | 0.707869↓ (p = 0.000022) |
 | Fatty Acid Oxidation |  |  |
Cpt1a Acc: NM_031559.2 ID: 25757 | Carnitine palmitoyltransferase 1a, liver (CPT-1a) | 2.093217↑ (p = 0.000002) | 0.935127 (p = 0.569094) |
Cpt1b Acc: NM_013200.1 ID: 25756 | Carnitine palmitoyltransferase 1b, muscle (CPT-1B, M-CPT1) | 0.955041 (p = 0.714963) | 4.901597↑ (p = 1.32E-23) |
Cpt1c Acc: NM_001034925.2 ID: 308579 | Carnitine palmitoyltransferase 1c (CPT 1C, CPT1-B, CPTI-B) | 0.786901 (p = 0.063481) | 0.809912 (p = 0.13046) |
Cpt2 Acc: NM_012930.1 ID: 25413 | Carnitine palmitoyltransferase 2 (CPTII) | 1.119695 (p = 0.344743) | 2.583082↑ (p = 1.88E-16) |
Acox1 Acc: NM_017340.2 ID: 506811 | Acyl-CoA oxidase, palmitoyl (Rat ACOA1) | 1.116564 (p = 0.176539) | 3.27028↑ (p = 5.20E-32) |
Acadl Acc: NM_012819.1 ID: 25287 | Acyl-CoA dehydrogenase, long chain (ACOADA, LCAD) | 1.156082 (p = 0.178078) | 1.023617 (p = 0.843391) |
Acadm Acc: NM_016986.2 ID: 24158 | Acyl-CoA dehydrogenase, C-4 to C-12 straight chain (MCAD) | 0.871033 (p = 0.206145) | 1.171654 (p = 0.099023) |
Acads Acc: NM_022512.1 ID: 64304 | Acyl-Coa dehydrogenase, C-2 to C-3 short chain (Scad) | 1.125432 (p = 0.554859) | 0.919627 (p = 0.563538) |
Acadsb Acc: NM_013084.1 ID: 25618 | Acyl-CoA dehydrogenase, short/branched chain | 1.060392 (p = 0.645381) | 0.700742↓ (p = 0.030057) |
Acadvl Acc: NM_012891.1 ID: 25363 | Acyl-CoA dehydrogenase very long chain (VLCAD) | 1.034174 (p = 0.763361) | 1.322826↑ (p = 0.003236) |
Eci1 Acc: NM_017306.4 ID: 29740 | Enoyl-CoA delta isomerase 1(Deci) | 0.991668 (p = 0.91246) | 2.461649↑ (p = 1.48E-11) |
Echs1 Acc: NM_078623.2 ID: 140547 | Enoy-CoA hydratase, short chain 1, mitochondrial | 1.001718 (p = 0.984367) | 0.982888 (p = 0.872986) |
Ehhadh Acc: NM_133606.1 ID: 171142 | Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase | 1.159127 (p = 0.181858) | 5.837078↑ (p = 2.67E-36) |
Eci2 Acc: NM_001006966.1 ID:291075 | Enoyl-CoA delta isomerase 2 (Peci) | 1.109171 (p = 0.294883) | 1.04819 (p = 0.563012) |
 | Fatty Acid Synthesis/ De Novo Lipogenesis |  |  |
Gckr Acc: NM_013120.2 ID: 25658 | Glucokinase (hexokinase 4) regulator (GLRE) | 1.225835↑ (p = 0.00735) | 0.842312↓ (p = 0.029236) |
Gck Acc: NM_012565.1 ID: 24385 | Glukokinase (GLUKA, RNGK2) | 1.954322↑ (p = 2.09E-18) | 0.6409↓ (p = 9.91E-08) |
Pklr Acc: NM_012624.3 ID: 24651 | Pyruvate kinase, liver and RBC (PK1, PKL, Pklg) | 2.101247↑ (p = 0.013312) | 0.763246 (p = 0.331269) |
Acly Acc: NM_016987.2 NM_001111095.1 ID: 24159 | ATP citrate lyase (ACL, Clatp) | 3.860112↑ (p = 8.66E-38) | 0.669940↓ (p = 0.000006) |
Fasn Acc: NM_01332.1 ID: 50761 | Fatty acid synthase | 8.556156↑ (p = 00E + 00) | 0.448329↓ (p = 2.08E-16) |
Me1 Acc: NM_012600.2 ID: 24552 | Malic enzyme 1, NADP(+)-dependent, cytosolic (MOD1) | 8.437617↑ (p = 2.81E-20) | 1.132866 (p = 0.447740) |
Me2 Acc: NM_001111095.1 ID: 307270 | Malic enzyme 2, NAD(+)-dependent, mitochondrial | — | — |
Scd1 Acc: NM_139192.2 ID: 246074 | Stearyol-Coenzyme A desaturase 1 | 9.689369↑ (p = 1.82E-38) | 0.563616↓ (p = 3.64E-11) |
Elovl1 Acc: NM_001044275.1 ID: 67953.2 | ELOVL fatty acid elongase 1 | 0.996626 (p = 0.968014) and 0.943940 (p = 0.460163) | 0.956685 (p = 0.573719) and 1.033276 (p = 0.664855) |
Elovl2 Acc: NM_001109118.1 ID: 498728 | ELOVL fatty acid elongase 2 | 2.461290↑ (p = 6.36E-19) | 0.498430↓ (p = 3.66E-11) |
Elovl4 Acc: NM_001191796.1 XM_001062735.2 ID: 315851 | ELOVL fatty acid elongase 4 | 0.823072 (p = 0.428065) | 1.658203↑ (p = 0.022936) |
Elovl5 Acc: NM_134382.1 ID: 171400 | ELOVL fatty acid elongase 5 (rELO1) | 1.898944↑ (p = 1.23E-11) | 0.416035↓ (p = 1.73E-17) |
Elovl6 Acc: NM_134383.2 ID: 171402 | ELOVL fatty acid elongase 6 (Lce2, rELO2) | 9.009938↑ (p = 0.00E + 00) and 2.808326↑ (p = 5.04E-11) | 1.516732↑ (p = 6.34E-09) and 1.466229↑ (p = 0.000012) |
Fads1 Acc: NM_053445.2 ID: 84575 | Fatty acid desaturase 1 | 1.241893↑ (p = 0.044164) | 0.760081↓ (p = 0.006978) |
Fads2 Acc: NM_031344.2 ID: 83512 | Fatty acid desaturase 2 (Fadsd6) | 2.161421↑ (p = 8.64E-12) | 0.699797↓ (p = 0.000734) |
Mlcyd Acc: NM_053477.1 ID: 85239 | Malonyl-CoA decarboxylase | 1.018118 (p = 0.862908) | 1.421141↑ (p = 0.000017) |
 | Triglyceride (TG) Synthesis/VLDL-TG Assembly |  |  |
Agpat1 Acc: NM_212458.1 ID: 406165 | 1-Acylglycerol-3-phosphate O-acyltransferase 1 | 0.695809↓ (p = 0.00083) | 0.906865 (p = 0.595394) |
Agpat2 Acc: NM_001107821.1 ID: 311821 | 1-Acylglycerol-3-phosphate O-acyltransferase 2 | 0.846901 (p = 0.109629) | 1.048686 (p = 0.622341) |
Agpat3 Acc: NM_001106378.1 ID: 311821 | 1-Acylglycerol-3-phosphate O-acyltransferase 3 | 0.848841 (p = 0.540663) | 0.895847 (p = 0.800248) |
Agpat6 Acc: NM_001047849.1 ID: 305166 | 1-Acylglycerol-3-phosphate O-acyltransferase 6 (RGD1310520) | 1.024470 (p = 0.740343) | 0.977072 (p = 0.773786) |
Agpat9 Acc: NM_001025670.1 ID: 305166 | 1-Acylglycerol-3-phosphate O-acyltransferase 9 | ─ | ─ |
Mogat1 Acc: NM_001108803.1 ID: 363261 | Monoacylglycerol O-acyltransferase 1 | 0.682029 (p = 0.154868) | 1.75896↑ (p = 0.030197) |
Dgat1 Acc: NM_053437.1 ID: 84497 | Diacylglycerol O-acyltransferase 1 (ARAT, Dgat) | 1.222808↑ (p = 0.030522) | 1.067215 (p = 0.527579) |
Dgat2 Acc: NM_001012345.1 ID: 252900 | Diacylglycerol O-acyltransferase 2 (ARAT) | 1.171782 (p = 0.67572) | 0.664628↓ (p = 0.000124) |
Arf3 Acc: NM_080904.2 ID: 140940 | ADP-ribosylation factor 3 (AC1-253) Cholesterol Synthesis/Metabolism | 1.046754 (p = 0.67572) | 0.743228↓ (p = 0.001530) |
 | Cholesterol Synthesis/Metabolism |  |  |
Acat2 Acc: NM_001006995.1 ID: 308100 | Acetyl-CoA acetyltransferase 2 (Acat3, Ab2-076) | 0.944516 (p = 0.461984) | 0.957373 (p = 0.56688) |
Hmgcr Acc: NM_013134.2 ID: 25675 | 3-Hydroxy-3-methylglutaryl-CoA reductase (3H3M) | 1.438208↑ (p = 0.000036) | 0.735862↓ (p = 0.002838) |
Insig 1 Acc: NM_022392.1 ID: 64194 | Insulin induced gene 1 | 2.844270↑ (p = 9.18E-16) | 0.542157↓ (p = 0.000001) |
Insig 2 Acc: NM_178091.4 ID: 288985 | Insulin induced gene 2 | 0.831160↓ (p = 0.044277) | 0.630641↓ (p = 8.36E-09) |
Ldlr Acc: NM_175762.2 ID: 300438 | Low density lipoprotein receptor (LDLRA) | 1.439569↑ (p = 0.003984) | 0.840219 (p = 0.137488) |
Mvk Acc: NM_031063.1 ID: 81727 | Mevalonate kinase (Lrbp) | 0.663626↓ (p = 0.000016) | 1.149403 (p = 0.234165) |
Scap Acc: NM_001100966.1 ID: 301024 | SREBF chaperone Proteins Involved in Lipid Clearance | 1.171144↑ (p = 0.035192) | 0.995421 (p = 0.941247) |
 | Proteins Involved in Lipid Clearance |  |  |
Abca4 Acc: NM_00110772.1 ID: 310836 | ATP-binding cassette, subfamily A (ABC1), member 4 (ABCR) | ─ | ─ |
Abcb4 Acc: NM_012690.1 ID: 24891 | ATP-binding cassette, subfamily B (MDR/TAP), member 4 (Mdr2, Pgy3) | 0.489385↓ (p = 3.69E-12) | 1.099759 (p = 0.27820) |
Abcb11 Acc: NM_031760.1 ID: 83569 | ATP-binding cassette, subfamily B (MDR/TAP), member 11 (Bsep, Spgp) | 0.752953↓ (p = 0.001332) | 1.158787 (p = 0.07294) |
Abcc3 Acc: NM_080581.1 ID: 140668 | ATP-binding cassette, subfamily C (CFTR/MRP), member 3 (Mlp2, Mrp3) | 0.813337 (p = 0.08045) | 2.659410↑ (p = 7.16E-11) |
Abcc6 Acc: NM_031013.1 ID: 81642 | ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Mrp6) | 1.085723 (p = 0.31384) | 0.717441↓ (p = 0.00001) |
Abcd1 Acc: NM_001108821.1 ID: 363516 | ATP-binding cassette, subfamily D (ALD), member 3 (RGD1562128) | 1.087157 (p = 0.468224) | 0.943107 (p = 0.56163) |
Abcd3 Acc: NM_012804.1 ID: 25270 | ATP-binging cassette, subfamily D (ALD), member 3 (PMP70, Pxmp1) | 1.178867↑ (p = 0.035741) | 2.15542↑ (p = 2.62E-16) |
Abcg2 Acc: NM_181381.2 ID: 312382 | ATP-binding cassette, subfamily G (WHITE), member 2 (BCRP1) | 1.940981↑ (p = 0.000000) | 1.140117 (p = 0.258891) |
Abcg5 Acc: NM_053754.2 ID: 114628 | ATP-binding cassette, subfamily G (WHITE), member 5 | 0.297237↓ (p = 5.23E-28) | 3.499936↑ (p = 5.81E-28) |
Apoa4 Acc: NM_012737.1 ID: 25080 | Apolipoprotein A-IV (Apo-AIV, ApoA-IV, ApoAIV) | 1.316723↑ (p = 0.025675) | 0.447885↓ (p = 1.8E-10) |
Apob Acc: NM_019287.2 ID: 54225 | Apolipoprotein B (Aa1064, AC1-060, Apo B-100, ApoB-100, ApoB-48) | 0.895361 (p = 0.277000) | 1.130493 (p = 0.142599) |
Apoc2 Acc: NM_001085352.1 ID: 292697 | Apolipoprotein C-II (RGD1560725) | 0.981675 (p = 0.864333) | 0.941418 (p = 0.591544) |
Apoc3 Acc: NM_012501.1 ID: 24207 | Apolipoprotein C-III (ApoC-III, apo-CIII) | 0.887282 (p = 0.221273) | 1.133806 (p = 0.221176) |
Apoe Acc: NM_138828.2 ID: 25728 | Apolipoprotein E (APOEA) | 0.953286 (p = 0.543392) | 0.968783 (p = 0.800654) |
Apof Acc: NM_001024351.1 ID: 500761 | Apolipoprotein F | 1.053397 (p = 0.630710) | 0.558207↓ (p = 0.000001) |
Lpl Acc: NM_012498.2 ID: 24539 | Lipoprotein lipase | 1.300129↑ (p = 0.024577) | 3.799195↑ (p = 1.34E-16) |
Vldlr Acc: NM_013155.2 ID: 25696 | Very low density lipoprotein receptor | 0.993145 (p = 0.973839) Or 1.103786 (p = 0.800081) | 1.615341↑ (p = 0.012976) Or 1.454645 (p = 0.304421) |
Ppt1 Acc: NM_022502.2 ID: 29411 | Palmitoyl-protein thioesterase 1 (Ppt) | 1.055246 (p = 0.5199114) | 0.882921 (p = 0.192733) |
 | Central Metabolic Regulators (Lipid Transcription Factors) |  |  |
Foxa1 Acc: NM_012742.1 ID: 25098 | Forkhead box A1 | 1.489049↑ (p = 0.001314) Or 1.271372↑ (p = 037977) | 0.831777 (p = 0.136951) Or 0.645434↓ (p = 0.000052) |
Hnf4a Acc: NM_022180.1 ID: 25735 | Hepatocyte nuclear factor 4, alpha (Hnf4alpha, Hnf4a) | 0.912061 (p = 0.377142) | 1.357585↑ (p = 0.003965) |
Mlxipl Acc: NM_133552.1 ID: 171078 | MLX interacting protein-like (ChREBP, WS-bHLH, Wbscr14, bHLHd14) | 1.976840↑ (p = 1.9E-15) | 0.724559↓ (p = 0.000044) |
Nr1h3 Acc: NM_031627.2 ID: 58852 | Nuclear receptor subfamily 1, group H, member 3 (LXRalpha) | 0.980054 (p = 0.831777) | 1.208346↑ (p = 0.041273) |
Ppara Acc: NM_013196.1 ID: 25747 | Peroxisome proliferator activated receptor alpha (PPAR) | 1.009554 (p = 0.946257) | 1.760026↑ (p = 0.000067) |
Ppard Acc: NM_013141.2 ID: 25682 | Peroxisome proliferator activated receptor delta (Pparb) | 0.843786 (p = 0.226207) and 1.189417 (p = 0.204488) | 0.753122 (p = 0.144411) and 0.635361↓ (p = 0.029129 |
Pparg Acc: NM_013124.3 NM_001145366.1 NM_001145367.1 ID: 25664 | Peroxisome proliferator activated receptor gamma | 1.010459 (p = 0.879959) | 1.03214 (p = 0.742011) |
Ppargc1a Acc: NM_031347.1 ID: 83516 | Peroxisome proliferator activated receptor gamma, coactivator 1 alpha(Ppargc1) | 0.738155 (p = 0.120955) | ─ |
Ppargc1b Acc: NM_176075.2 ID: 291567 | Peroxisome proliferator activated receptor, coactivator 1 beta (PGC1beta, Perc) | 0.969931 (p = 0.815666) | 1.534911↑ (p = 0.012486) |
Srebf1 Acc: XM_213329.5 XM_001075680.2 ID: 78968 | Sterol regulatory element binding transcription factor 1 (ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1) | 1.604384↑ (p = 0.000000) and 1.456690↑ (p = 0.001744) | 0.8782 (p = 0.125948) and 0.934259 (p = 0.479001) |
Srebf2 Acc: NM_001033694.1 ID: 300095 | Sterol regulatory element binding transcription factor 2 (SREBP-2, SREBP2-retired, Srebf2) | 0.732025↓ (p = 0.000761) | 1.071545 (p = 0.478687) |
Xbp1 Acc: NM_001004210.1 ID: 289754 | X-box binding protein 1 (HTF) | 1.148942 (p = 0.076252) | 0.807070↓ (p = 0.016697) |