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Table 1 Hepatic genes responsive to feeding of a high-fructose diet (HFrD) or HFrD supplemented with NDGA (HFrD-NDGA)

From: Microarray analysis of gene expression in liver, adipose tissue and skeletal muscle in response to chronic dietary administration of NDGA to high-fructose fed dyslipidemic rats

Gene symbol/GenBank accession/Gene ID Entrez gene name HFrD/Chow (Fold-change) HFrD-NDGA/HFrD (Fold-change)
  Fatty Acid Transport   
Slc27a1 Acc: NM_053580.2 ID: 94172 Soluble carrier family 27 (fatty acid transporter), member 1 (FATP1) 0.817382 (p = 0.050249) 1.085686 (p = 0.548792)
Slc27a2 Acc: NM_031736.1 ID: 65192 Soluble carrier family 27 (fatty acid transporter), member 2 (FATP2) 1.276261↑ (p = 0.017602) 1.071673 (p = 0.458057)
  Acyl-CoA Synthetases   
Acsl1 Acc: NM_012820.1 ID: 25288 Acyl-CoA synthetase long-chain family member 1 (ACS, Acas, COAA, Facl2) 1.058003 (p = 0.59888) 1.286236↑ (p = 0.015343)
Acsl4 Acc: NM_053623.1 ID: 113976 Acyl-CoA synthetase long-chain family member 4 (ACS4, Facl4) 1.673512↑ (p = 0.000004) 0.697139↓ (p = 0.001224)
Acsm3 Acc: NM_033231.1 ID: 24763 Acyl-CoA synthetase medium-chain family member 3 (Sa, Sah) 0.458851↓ (p = 0.000004) 1.583156↑ (p = 0.000039)
Acss2 Acc: NM_001107793.1 ID: 311569 Acyl-CoA synthetase short chain family member 2 (Acss2) 1.640823↑ (p = 5.92E-09) 0.707869↓ (p = 0.000022)
  Fatty Acid Oxidation   
Cpt1a Acc: NM_031559.2 ID: 25757 Carnitine palmitoyltransferase 1a, liver (CPT-1a) 2.093217↑ (p = 0.000002) 0.935127 (p = 0.569094)
Cpt1b Acc: NM_013200.1 ID: 25756 Carnitine palmitoyltransferase 1b, muscle (CPT-1B, M-CPT1) 0.955041 (p = 0.714963) 4.901597↑ (p = 1.32E-23)
Cpt1c Acc: NM_001034925.2 ID: 308579 Carnitine palmitoyltransferase 1c (CPT 1C, CPT1-B, CPTI-B) 0.786901 (p = 0.063481) 0.809912 (p = 0.13046)
Cpt2 Acc: NM_012930.1 ID: 25413 Carnitine palmitoyltransferase 2 (CPTII) 1.119695 (p = 0.344743) 2.583082↑ (p = 1.88E-16)
Acox1 Acc: NM_017340.2 ID: 506811 Acyl-CoA oxidase, palmitoyl (Rat ACOA1) 1.116564 (p = 0.176539) 3.27028↑ (p = 5.20E-32)
Acadl Acc: NM_012819.1 ID: 25287 Acyl-CoA dehydrogenase, long chain (ACOADA, LCAD) 1.156082 (p = 0.178078) 1.023617 (p = 0.843391)
Acadm Acc: NM_016986.2 ID: 24158 Acyl-CoA dehydrogenase, C-4 to C-12 straight chain (MCAD) 0.871033 (p = 0.206145) 1.171654 (p = 0.099023)
Acads Acc: NM_022512.1 ID: 64304 Acyl-Coa dehydrogenase, C-2 to C-3 short chain (Scad) 1.125432 (p = 0.554859) 0.919627 (p = 0.563538)
Acadsb Acc: NM_013084.1 ID: 25618 Acyl-CoA dehydrogenase, short/branched chain 1.060392 (p = 0.645381) 0.700742↓ (p = 0.030057)
Acadvl Acc: NM_012891.1 ID: 25363 Acyl-CoA dehydrogenase very long chain (VLCAD) 1.034174 (p = 0.763361) 1.322826↑ (p = 0.003236)
Eci1 Acc: NM_017306.4 ID: 29740 Enoyl-CoA delta isomerase 1(Deci) 0.991668 (p = 0.91246) 2.461649↑ (p = 1.48E-11)
Echs1 Acc: NM_078623.2 ID: 140547 Enoy-CoA hydratase, short chain 1, mitochondrial 1.001718 (p = 0.984367) 0.982888 (p = 0.872986)
Ehhadh Acc: NM_133606.1 ID: 171142 Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase 1.159127 (p = 0.181858) 5.837078↑ (p = 2.67E-36)
Eci2 Acc: NM_001006966.1 ID:291075 Enoyl-CoA delta isomerase 2 (Peci) 1.109171 (p = 0.294883) 1.04819 (p = 0.563012)
  Fatty Acid Synthesis/ De Novo Lipogenesis   
Gckr Acc: NM_013120.2 ID: 25658 Glucokinase (hexokinase 4) regulator (GLRE) 1.225835↑ (p = 0.00735) 0.842312↓ (p = 0.029236)
Gck Acc: NM_012565.1 ID: 24385 Glukokinase (GLUKA, RNGK2) 1.954322↑ (p = 2.09E-18) 0.6409↓ (p = 9.91E-08)
Pklr Acc: NM_012624.3 ID: 24651 Pyruvate kinase, liver and RBC (PK1, PKL, Pklg) 2.101247↑ (p = 0.013312) 0.763246 (p = 0.331269)
Acly Acc: NM_016987.2 NM_001111095.1 ID: 24159 ATP citrate lyase (ACL, Clatp) 3.860112↑ (p = 8.66E-38) 0.669940↓ (p = 0.000006)
Fasn Acc: NM_01332.1 ID: 50761 Fatty acid synthase 8.556156↑ (p = 00E + 00) 0.448329↓ (p = 2.08E-16)
Me1 Acc: NM_012600.2 ID: 24552 Malic enzyme 1, NADP(+)-dependent, cytosolic (MOD1) 8.437617↑ (p = 2.81E-20) 1.132866 (p = 0.447740)
Me2 Acc: NM_001111095.1 ID: 307270 Malic enzyme 2, NAD(+)-dependent, mitochondrial
Scd1 Acc: NM_139192.2 ID: 246074 Stearyol-Coenzyme A desaturase 1 9.689369↑ (p = 1.82E-38) 0.563616↓ (p = 3.64E-11)
Elovl1 Acc: NM_001044275.1 ID: 67953.2 ELOVL fatty acid elongase 1 0.996626 (p = 0.968014) and 0.943940 (p = 0.460163) 0.956685 (p = 0.573719) and 1.033276 (p = 0.664855)
Elovl2 Acc: NM_001109118.1 ID: 498728 ELOVL fatty acid elongase 2 2.461290↑ (p = 6.36E-19) 0.498430↓ (p = 3.66E-11)
Elovl4 Acc: NM_001191796.1 XM_001062735.2 ID: 315851 ELOVL fatty acid elongase 4 0.823072 (p = 0.428065) 1.658203↑ (p = 0.022936)
Elovl5 Acc: NM_134382.1 ID: 171400 ELOVL fatty acid elongase 5 (rELO1) 1.898944↑ (p = 1.23E-11) 0.416035↓ (p = 1.73E-17)
Elovl6 Acc: NM_134383.2 ID: 171402 ELOVL fatty acid elongase 6 (Lce2, rELO2) 9.009938↑ (p = 0.00E + 00) and 2.808326↑ (p = 5.04E-11) 1.516732↑ (p = 6.34E-09) and 1.466229↑ (p = 0.000012)
Fads1 Acc: NM_053445.2 ID: 84575 Fatty acid desaturase 1 1.241893↑ (p = 0.044164) 0.760081↓ (p = 0.006978)
Fads2 Acc: NM_031344.2 ID: 83512 Fatty acid desaturase 2 (Fadsd6) 2.161421↑ (p = 8.64E-12) 0.699797↓ (p = 0.000734)
Mlcyd Acc: NM_053477.1 ID: 85239 Malonyl-CoA decarboxylase 1.018118 (p = 0.862908) 1.421141↑ (p = 0.000017)
  Triglyceride (TG) Synthesis/VLDL-TG Assembly   
Agpat1 Acc: NM_212458.1 ID: 406165 1-Acylglycerol-3-phosphate O-acyltransferase 1 0.695809↓ (p = 0.00083) 0.906865 (p = 0.595394)
Agpat2 Acc: NM_001107821.1 ID: 311821 1-Acylglycerol-3-phosphate O-acyltransferase 2 0.846901 (p = 0.109629) 1.048686 (p = 0.622341)
Agpat3 Acc: NM_001106378.1 ID: 311821 1-Acylglycerol-3-phosphate O-acyltransferase 3 0.848841 (p = 0.540663) 0.895847 (p = 0.800248)
Agpat6 Acc: NM_001047849.1 ID: 305166 1-Acylglycerol-3-phosphate O-acyltransferase 6 (RGD1310520) 1.024470 (p = 0.740343) 0.977072 (p = 0.773786)
Agpat9 Acc: NM_001025670.1 ID: 305166 1-Acylglycerol-3-phosphate O-acyltransferase 9
Mogat1 Acc: NM_001108803.1 ID: 363261 Monoacylglycerol O-acyltransferase 1 0.682029 (p = 0.154868) 1.75896↑ (p = 0.030197)
Dgat1 Acc: NM_053437.1 ID: 84497 Diacylglycerol O-acyltransferase 1 (ARAT, Dgat) 1.222808↑ (p = 0.030522) 1.067215 (p = 0.527579)
Dgat2 Acc: NM_001012345.1 ID: 252900 Diacylglycerol O-acyltransferase 2 (ARAT) 1.171782 (p = 0.67572) 0.664628↓ (p = 0.000124)
Arf3 Acc: NM_080904.2 ID: 140940 ADP-ribosylation factor 3 (AC1-253) Cholesterol Synthesis/Metabolism 1.046754 (p = 0.67572) 0.743228↓ (p = 0.001530)
  Cholesterol Synthesis/Metabolism   
Acat2 Acc: NM_001006995.1 ID: 308100 Acetyl-CoA acetyltransferase 2 (Acat3, Ab2-076) 0.944516 (p = 0.461984) 0.957373 (p = 0.56688)
Hmgcr Acc: NM_013134.2 ID: 25675 3-Hydroxy-3-methylglutaryl-CoA reductase (3H3M) 1.438208↑ (p = 0.000036) 0.735862↓ (p = 0.002838)
Insig 1 Acc: NM_022392.1 ID: 64194 Insulin induced gene 1 2.844270↑ (p = 9.18E-16) 0.542157↓ (p = 0.000001)
Insig 2 Acc: NM_178091.4 ID: 288985 Insulin induced gene 2 0.831160↓ (p = 0.044277) 0.630641↓ (p = 8.36E-09)
Ldlr Acc: NM_175762.2 ID: 300438 Low density lipoprotein receptor (LDLRA) 1.439569↑ (p = 0.003984) 0.840219 (p = 0.137488)
Mvk Acc: NM_031063.1 ID: 81727 Mevalonate kinase (Lrbp) 0.663626↓ (p = 0.000016) 1.149403 (p = 0.234165)
Scap Acc: NM_001100966.1 ID: 301024 SREBF chaperone Proteins Involved in Lipid Clearance 1.171144↑ (p = 0.035192) 0.995421 (p = 0.941247)
  Proteins Involved in Lipid Clearance   
Abca4 Acc: NM_00110772.1 ID: 310836 ATP-binding cassette, subfamily A (ABC1), member 4 (ABCR)
Abcb4 Acc: NM_012690.1 ID: 24891 ATP-binding cassette, subfamily B (MDR/TAP), member 4 (Mdr2, Pgy3) 0.489385↓ (p = 3.69E-12) 1.099759 (p = 0.27820)
Abcb11 Acc: NM_031760.1 ID: 83569 ATP-binding cassette, subfamily B (MDR/TAP), member 11 (Bsep, Spgp) 0.752953↓ (p = 0.001332) 1.158787 (p = 0.07294)
Abcc3 Acc: NM_080581.1 ID: 140668 ATP-binding cassette, subfamily C (CFTR/MRP), member 3 (Mlp2, Mrp3) 0.813337 (p = 0.08045) 2.659410↑ (p = 7.16E-11)
Abcc6 Acc: NM_031013.1 ID: 81642 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Mrp6) 1.085723 (p = 0.31384) 0.717441↓ (p = 0.00001)
Abcd1 Acc: NM_001108821.1 ID: 363516 ATP-binding cassette, subfamily D (ALD), member 3 (RGD1562128) 1.087157 (p = 0.468224) 0.943107 (p = 0.56163)
Abcd3 Acc: NM_012804.1 ID: 25270 ATP-binging cassette, subfamily D (ALD), member 3 (PMP70, Pxmp1) 1.178867↑ (p = 0.035741) 2.15542↑ (p = 2.62E-16)
Abcg2 Acc: NM_181381.2 ID: 312382 ATP-binding cassette, subfamily G (WHITE), member 2 (BCRP1) 1.940981↑ (p = 0.000000) 1.140117 (p = 0.258891)
Abcg5 Acc: NM_053754.2 ID: 114628 ATP-binding cassette, subfamily G (WHITE), member 5 0.297237↓ (p = 5.23E-28) 3.499936↑ (p = 5.81E-28)
Apoa4 Acc: NM_012737.1 ID: 25080 Apolipoprotein A-IV (Apo-AIV, ApoA-IV, ApoAIV) 1.316723↑ (p = 0.025675) 0.447885↓ (p = 1.8E-10)
Apob Acc: NM_019287.2 ID: 54225 Apolipoprotein B (Aa1064, AC1-060, Apo B-100, ApoB-100, ApoB-48) 0.895361 (p = 0.277000) 1.130493 (p = 0.142599)
Apoc2 Acc: NM_001085352.1 ID: 292697 Apolipoprotein C-II (RGD1560725) 0.981675 (p = 0.864333) 0.941418 (p = 0.591544)
Apoc3 Acc: NM_012501.1 ID: 24207 Apolipoprotein C-III (ApoC-III, apo-CIII) 0.887282 (p = 0.221273) 1.133806 (p = 0.221176)
Apoe Acc: NM_138828.2 ID: 25728 Apolipoprotein E (APOEA) 0.953286 (p = 0.543392) 0.968783 (p = 0.800654)
Apof Acc: NM_001024351.1 ID: 500761 Apolipoprotein F 1.053397 (p = 0.630710) 0.558207↓ (p = 0.000001)
Lpl Acc: NM_012498.2 ID: 24539 Lipoprotein lipase 1.300129↑ (p = 0.024577) 3.799195↑ (p = 1.34E-16)
Vldlr Acc: NM_013155.2 ID: 25696 Very low density lipoprotein receptor 0.993145 (p = 0.973839) Or 1.103786 (p = 0.800081) 1.615341↑ (p = 0.012976) Or 1.454645 (p = 0.304421)
Ppt1 Acc: NM_022502.2 ID: 29411 Palmitoyl-protein thioesterase 1 (Ppt) 1.055246 (p = 0.5199114) 0.882921 (p = 0.192733)
  Central Metabolic Regulators (Lipid Transcription Factors)   
Foxa1 Acc: NM_012742.1 ID: 25098 Forkhead box A1 1.489049↑ (p = 0.001314) Or 1.271372↑ (p = 037977) 0.831777 (p = 0.136951) Or 0.645434↓ (p = 0.000052)
Hnf4a Acc: NM_022180.1 ID: 25735 Hepatocyte nuclear factor 4, alpha (Hnf4alpha, Hnf4a) 0.912061 (p = 0.377142) 1.357585↑ (p = 0.003965)
Mlxipl Acc: NM_133552.1 ID: 171078 MLX interacting protein-like (ChREBP, WS-bHLH, Wbscr14, bHLHd14) 1.976840↑ (p = 1.9E-15) 0.724559↓ (p = 0.000044)
Nr1h3 Acc: NM_031627.2 ID: 58852 Nuclear receptor subfamily 1, group H, member 3 (LXRalpha) 0.980054 (p = 0.831777) 1.208346↑ (p = 0.041273)
Ppara Acc: NM_013196.1 ID: 25747 Peroxisome proliferator activated receptor alpha (PPAR) 1.009554 (p = 0.946257) 1.760026↑ (p = 0.000067)
Ppard Acc: NM_013141.2 ID: 25682 Peroxisome proliferator activated receptor delta (Pparb) 0.843786 (p = 0.226207) and 1.189417 (p = 0.204488) 0.753122 (p = 0.144411) and 0.635361↓ (p = 0.029129
Pparg Acc: NM_013124.3 NM_001145366.1 NM_001145367.1 ID: 25664 Peroxisome proliferator activated receptor gamma 1.010459 (p = 0.879959) 1.03214 (p = 0.742011)
Ppargc1a Acc: NM_031347.1 ID: 83516 Peroxisome proliferator activated receptor gamma, coactivator 1 alpha(Ppargc1) 0.738155 (p = 0.120955)
Ppargc1b Acc: NM_176075.2 ID: 291567 Peroxisome proliferator activated receptor, coactivator 1 beta (PGC1beta, Perc) 0.969931 (p = 0.815666) 1.534911↑ (p = 0.012486)
Srebf1 Acc: XM_213329.5 XM_001075680.2 ID: 78968 Sterol regulatory element binding transcription factor 1 (ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1) 1.604384↑ (p = 0.000000) and 1.456690↑ (p = 0.001744) 0.8782 (p = 0.125948) and 0.934259 (p = 0.479001)
Srebf2 Acc: NM_001033694.1 ID: 300095 Sterol regulatory element binding transcription factor 2 (SREBP-2, SREBP2-retired, Srebf2) 0.732025↓ (p = 0.000761) 1.071545 (p = 0.478687)
Xbp1 Acc: NM_001004210.1 ID: 289754 X-box binding protein 1 (HTF) 1.148942 (p = 0.076252) 0.807070↓ (p = 0.016697)