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Table 1 Hepatic genes responsive to feeding of a high-fructose diet (HFrD) or HFrD supplemented with NDGA (HFrD-NDGA)

From: Microarray analysis of gene expression in liver, adipose tissue and skeletal muscle in response to chronic dietary administration of NDGA to high-fructose fed dyslipidemic rats

Gene symbol/GenBank accession/Gene ID Entrez gene name HFrD/Chow (Fold-change) HFrD-NDGA/HFrD (Fold-change)
  Fatty Acid Transport   
Slc27a1
Acc: NM_053580.2
ID: 94172
Soluble carrier family 27 (fatty acid transporter), member 1 (FATP1) 0.817382
(p = 0.050249)
1.085686
(p = 0.548792)
Slc27a2
Acc: NM_031736.1
ID: 65192
Soluble carrier family 27 (fatty acid transporter), member 2 (FATP2) 1.276261↑
(p = 0.017602)
1.071673
(p = 0.458057)
  Acyl-CoA Synthetases   
Acsl1
Acc: NM_012820.1
ID: 25288
Acyl-CoA synthetase long-chain family member 1 (ACS, Acas, COAA, Facl2) 1.058003
(p = 0.59888)
1.286236↑
(p = 0.015343)
Acsl4
Acc: NM_053623.1
ID: 113976
Acyl-CoA synthetase long-chain family member 4 (ACS4, Facl4) 1.673512↑
(p = 0.000004)
0.697139↓
(p = 0.001224)
Acsm3
Acc: NM_033231.1
ID: 24763
Acyl-CoA synthetase medium-chain family member 3 (Sa, Sah) 0.458851↓
(p = 0.000004)
1.583156↑
(p = 0.000039)
Acss2
Acc: NM_001107793.1
ID: 311569
Acyl-CoA synthetase short chain family member 2 (Acss2) 1.640823↑
(p = 5.92E-09)
0.707869↓
(p = 0.000022)
  Fatty Acid Oxidation   
Cpt1a
Acc: NM_031559.2
ID: 25757
Carnitine palmitoyltransferase 1a, liver (CPT-1a) 2.093217↑
(p = 0.000002)
0.935127
(p = 0.569094)
Cpt1b
Acc: NM_013200.1
ID: 25756
Carnitine palmitoyltransferase 1b, muscle (CPT-1B, M-CPT1) 0.955041
(p = 0.714963)
4.901597↑
(p = 1.32E-23)
Cpt1c
Acc: NM_001034925.2
ID: 308579
Carnitine palmitoyltransferase 1c (CPT 1C, CPT1-B, CPTI-B) 0.786901
(p = 0.063481)
0.809912
(p = 0.13046)
Cpt2
Acc: NM_012930.1
ID: 25413
Carnitine palmitoyltransferase 2 (CPTII) 1.119695
(p = 0.344743)
2.583082↑
(p = 1.88E-16)
Acox1
Acc: NM_017340.2
ID: 506811
Acyl-CoA oxidase, palmitoyl (Rat ACOA1) 1.116564
(p = 0.176539)
3.27028↑
(p = 5.20E-32)
Acadl
Acc: NM_012819.1
ID: 25287
Acyl-CoA dehydrogenase, long chain (ACOADA, LCAD) 1.156082
(p = 0.178078)
1.023617
(p = 0.843391)
Acadm
Acc: NM_016986.2
ID: 24158
Acyl-CoA dehydrogenase, C-4 to C-12 straight chain (MCAD) 0.871033
(p = 0.206145)
1.171654
(p = 0.099023)
Acads
Acc: NM_022512.1
ID: 64304
Acyl-Coa dehydrogenase, C-2 to C-3 short chain (Scad) 1.125432
(p = 0.554859)
0.919627
(p = 0.563538)
Acadsb
Acc: NM_013084.1
ID: 25618
Acyl-CoA dehydrogenase, short/branched chain 1.060392
(p = 0.645381)
0.700742↓
(p = 0.030057)
Acadvl
Acc: NM_012891.1
ID: 25363
Acyl-CoA dehydrogenase very long chain (VLCAD) 1.034174
(p = 0.763361)
1.322826↑
(p = 0.003236)
Eci1
Acc: NM_017306.4
ID: 29740
Enoyl-CoA delta isomerase 1(Deci) 0.991668
(p = 0.91246)
2.461649↑
(p = 1.48E-11)
Echs1
Acc: NM_078623.2
ID: 140547
Enoy-CoA hydratase, short chain 1, mitochondrial 1.001718
(p = 0.984367)
0.982888
(p = 0.872986)
Ehhadh
Acc: NM_133606.1
ID: 171142
Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase 1.159127
(p = 0.181858)
5.837078↑
(p = 2.67E-36)
Eci2
Acc: NM_001006966.1
ID:291075
Enoyl-CoA delta isomerase 2 (Peci) 1.109171
(p = 0.294883)
1.04819
(p = 0.563012)
  Fatty Acid Synthesis/ De Novo Lipogenesis   
Gckr
Acc: NM_013120.2
ID: 25658
Glucokinase (hexokinase 4) regulator (GLRE) 1.225835↑
(p = 0.00735)
0.842312↓
(p = 0.029236)
Gck
Acc: NM_012565.1
ID: 24385
Glukokinase (GLUKA, RNGK2) 1.954322↑
(p = 2.09E-18)
0.6409↓
(p = 9.91E-08)
Pklr
Acc: NM_012624.3
ID: 24651
Pyruvate kinase, liver and RBC
(PK1, PKL, Pklg)
2.101247↑
(p = 0.013312)
0.763246
(p = 0.331269)
Acly
Acc: NM_016987.2
NM_001111095.1
ID: 24159
ATP citrate lyase (ACL, Clatp) 3.860112↑
(p = 8.66E-38)
0.669940↓
(p = 0.000006)
Fasn
Acc: NM_01332.1
ID: 50761
Fatty acid synthase 8.556156↑
(p = 00E + 00)
0.448329↓
(p = 2.08E-16)
Me1
Acc: NM_012600.2
ID: 24552
Malic enzyme 1, NADP(+)-dependent, cytosolic (MOD1) 8.437617↑
(p = 2.81E-20)
1.132866
(p = 0.447740)
Me2
Acc: NM_001111095.1
ID: 307270
Malic enzyme 2, NAD(+)-dependent, mitochondrial
Scd1
Acc: NM_139192.2
ID: 246074
Stearyol-Coenzyme A desaturase 1 9.689369↑
(p = 1.82E-38)
0.563616↓
(p = 3.64E-11)
Elovl1
Acc: NM_001044275.1
ID: 67953.2
ELOVL fatty acid elongase 1 0.996626
(p = 0.968014)
and
0.943940
(p = 0.460163)
0.956685
(p = 0.573719)
and
1.033276
(p = 0.664855)
Elovl2
Acc: NM_001109118.1
ID: 498728
ELOVL fatty acid elongase 2 2.461290↑
(p = 6.36E-19)
0.498430↓
(p = 3.66E-11)
Elovl4
Acc: NM_001191796.1 XM_001062735.2
ID: 315851
ELOVL fatty acid elongase 4 0.823072
(p = 0.428065)
1.658203↑
(p = 0.022936)
Elovl5
Acc: NM_134382.1
ID: 171400
ELOVL fatty acid elongase 5 (rELO1) 1.898944↑
(p = 1.23E-11)
0.416035↓
(p = 1.73E-17)
Elovl6
Acc: NM_134383.2
ID: 171402
ELOVL fatty acid elongase 6 (Lce2, rELO2) 9.009938↑
(p = 0.00E + 00)
and
2.808326↑
(p = 5.04E-11)
1.516732↑
(p = 6.34E-09)
and
1.466229↑
(p = 0.000012)
Fads1
Acc: NM_053445.2
ID: 84575
Fatty acid desaturase 1 1.241893↑
(p = 0.044164)
0.760081↓ (p = 0.006978)
Fads2
Acc: NM_031344.2
ID: 83512
Fatty acid desaturase 2 (Fadsd6) 2.161421↑ (p = 8.64E-12) 0.699797↓ (p = 0.000734)
Mlcyd
Acc: NM_053477.1
ID: 85239
Malonyl-CoA decarboxylase 1.018118
(p = 0.862908)
1.421141↑
(p = 0.000017)
  Triglyceride (TG) Synthesis/VLDL-TG Assembly   
Agpat1
Acc: NM_212458.1
ID: 406165
1-Acylglycerol-3-phosphate O-acyltransferase 1 0.695809↓
(p = 0.00083)
0.906865
(p = 0.595394)
Agpat2
Acc: NM_001107821.1
ID: 311821
1-Acylglycerol-3-phosphate O-acyltransferase 2 0.846901
(p = 0.109629)
1.048686
(p = 0.622341)
Agpat3
Acc: NM_001106378.1
ID: 311821
1-Acylglycerol-3-phosphate O-acyltransferase 3 0.848841
(p = 0.540663)
0.895847
(p = 0.800248)
Agpat6
Acc: NM_001047849.1
ID: 305166
1-Acylglycerol-3-phosphate O-acyltransferase 6 (RGD1310520) 1.024470
(p = 0.740343)
0.977072
(p = 0.773786)
Agpat9
Acc: NM_001025670.1
ID: 305166
1-Acylglycerol-3-phosphate O-acyltransferase 9
Mogat1
Acc: NM_001108803.1
ID: 363261
Monoacylglycerol O-acyltransferase 1 0.682029
(p = 0.154868)
1.75896↑
(p = 0.030197)
Dgat1
Acc: NM_053437.1
ID: 84497
Diacylglycerol O-acyltransferase 1 (ARAT, Dgat) 1.222808↑
(p = 0.030522)
1.067215
(p = 0.527579)
Dgat2
Acc: NM_001012345.1
ID: 252900
Diacylglycerol O-acyltransferase 2 (ARAT) 1.171782
(p = 0.67572)
0.664628↓
(p = 0.000124)
Arf3
Acc: NM_080904.2
ID: 140940
ADP-ribosylation factor 3 (AC1-253) Cholesterol Synthesis/Metabolism 1.046754
(p = 0.67572)
0.743228↓
(p = 0.001530)
  Cholesterol Synthesis/Metabolism   
Acat2
Acc: NM_001006995.1
ID: 308100
Acetyl-CoA acetyltransferase 2 (Acat3, Ab2-076) 0.944516
(p = 0.461984)
0.957373
(p = 0.56688)
Hmgcr
Acc: NM_013134.2
ID: 25675
3-Hydroxy-3-methylglutaryl-CoA reductase (3H3M) 1.438208↑
(p = 0.000036)
0.735862↓
(p = 0.002838)
Insig 1
Acc: NM_022392.1
ID: 64194
Insulin induced gene 1 2.844270↑
(p = 9.18E-16)
0.542157↓
(p = 0.000001)
Insig 2
Acc: NM_178091.4
ID: 288985
Insulin induced gene 2 0.831160↓
(p = 0.044277)
0.630641↓
(p = 8.36E-09)
Ldlr
Acc: NM_175762.2
ID: 300438
Low density lipoprotein receptor (LDLRA) 1.439569↑
(p = 0.003984)
0.840219
(p = 0.137488)
Mvk
Acc: NM_031063.1
ID: 81727
Mevalonate kinase (Lrbp) 0.663626↓
(p = 0.000016)
1.149403
(p = 0.234165)
Scap
Acc: NM_001100966.1
ID: 301024
SREBF chaperone Proteins Involved in Lipid Clearance 1.171144↑
(p = 0.035192)
0.995421
(p = 0.941247)
  Proteins Involved in Lipid Clearance   
Abca4
Acc: NM_00110772.1
ID: 310836
ATP-binding cassette, subfamily A (ABC1), member 4 (ABCR)
Abcb4
Acc: NM_012690.1
ID: 24891
ATP-binding cassette, subfamily B (MDR/TAP), member 4 (Mdr2, Pgy3) 0.489385↓
(p = 3.69E-12)
1.099759
(p = 0.27820)
Abcb11
Acc: NM_031760.1
ID: 83569
ATP-binding cassette, subfamily B (MDR/TAP), member 11 (Bsep, Spgp) 0.752953↓
(p = 0.001332)
1.158787
(p = 0.07294)
Abcc3
Acc: NM_080581.1
ID: 140668
ATP-binding cassette, subfamily C (CFTR/MRP), member 3 (Mlp2, Mrp3) 0.813337
(p = 0.08045)
2.659410↑
(p = 7.16E-11)
Abcc6
Acc: NM_031013.1
ID: 81642
ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Mrp6) 1.085723
(p = 0.31384)
0.717441↓
(p = 0.00001)
Abcd1
Acc: NM_001108821.1
ID: 363516
ATP-binding cassette, subfamily D (ALD), member 3 (RGD1562128) 1.087157
(p = 0.468224)
0.943107
(p = 0.56163)
Abcd3
Acc: NM_012804.1
ID: 25270
ATP-binging cassette, subfamily D (ALD), member 3 (PMP70, Pxmp1) 1.178867↑
(p = 0.035741)
2.15542↑
(p = 2.62E-16)
Abcg2
Acc: NM_181381.2
ID: 312382
ATP-binding cassette, subfamily G (WHITE), member 2 (BCRP1) 1.940981↑
(p = 0.000000)
1.140117
(p = 0.258891)
Abcg5
Acc: NM_053754.2
ID: 114628
ATP-binding cassette, subfamily G (WHITE), member 5 0.297237↓
(p = 5.23E-28)
3.499936↑
(p = 5.81E-28)
Apoa4
Acc: NM_012737.1
ID: 25080
Apolipoprotein A-IV (Apo-AIV, ApoA-IV, ApoAIV) 1.316723↑
(p = 0.025675)
0.447885↓
(p = 1.8E-10)
Apob
Acc: NM_019287.2
ID: 54225
Apolipoprotein B (Aa1064, AC1-060, Apo B-100, ApoB-100, ApoB-48) 0.895361
(p = 0.277000)
1.130493
(p = 0.142599)
Apoc2
Acc: NM_001085352.1
ID: 292697
Apolipoprotein C-II (RGD1560725) 0.981675
(p = 0.864333)
0.941418
(p = 0.591544)
Apoc3
Acc: NM_012501.1
ID: 24207
Apolipoprotein C-III (ApoC-III, apo-CIII) 0.887282
(p = 0.221273)
1.133806
(p = 0.221176)
Apoe
Acc: NM_138828.2
ID: 25728
Apolipoprotein E (APOEA) 0.953286
(p = 0.543392)
0.968783
(p = 0.800654)
Apof
Acc: NM_001024351.1
ID: 500761
Apolipoprotein F 1.053397
(p = 0.630710)
0.558207↓
(p = 0.000001)
Lpl
Acc: NM_012498.2
ID: 24539
Lipoprotein lipase 1.300129↑
(p = 0.024577)
3.799195↑
(p = 1.34E-16)
Vldlr
Acc: NM_013155.2
ID: 25696
Very low density lipoprotein receptor 0.993145
(p = 0.973839)
Or
1.103786
(p = 0.800081)
1.615341↑
(p = 0.012976)
Or
1.454645
(p = 0.304421)
Ppt1
Acc: NM_022502.2
ID: 29411
Palmitoyl-protein thioesterase 1 (Ppt) 1.055246
(p = 0.5199114)
0.882921
(p = 0.192733)
  Central Metabolic Regulators (Lipid Transcription Factors)   
Foxa1
Acc: NM_012742.1
ID: 25098
Forkhead box A1 1.489049↑
(p = 0.001314)
Or
1.271372↑
(p = 037977)
0.831777
(p = 0.136951)
Or
0.645434↓
(p = 0.000052)
Hnf4a
Acc: NM_022180.1
ID: 25735
Hepatocyte nuclear factor 4, alpha (Hnf4alpha, Hnf4a) 0.912061
(p = 0.377142)
1.357585↑
(p = 0.003965)
Mlxipl
Acc: NM_133552.1
ID: 171078
MLX interacting protein-like (ChREBP, WS-bHLH, Wbscr14, bHLHd14) 1.976840↑
(p = 1.9E-15)
0.724559↓
(p = 0.000044)
Nr1h3
Acc: NM_031627.2
ID: 58852
Nuclear receptor subfamily 1, group H, member 3 (LXRalpha) 0.980054
(p = 0.831777)
1.208346↑
(p = 0.041273)
Ppara
Acc: NM_013196.1
ID: 25747
Peroxisome proliferator activated receptor alpha (PPAR) 1.009554
(p = 0.946257)
1.760026↑
(p = 0.000067)
Ppard
Acc: NM_013141.2
ID: 25682
Peroxisome proliferator activated receptor delta (Pparb) 0.843786
(p = 0.226207)
and
1.189417
(p = 0.204488)
0.753122
(p = 0.144411)
and
0.635361↓
(p = 0.029129
Pparg
Acc: NM_013124.3
NM_001145366.1
NM_001145367.1
ID: 25664
Peroxisome proliferator activated receptor gamma 1.010459
(p = 0.879959)
1.03214
(p = 0.742011)
Ppargc1a
Acc: NM_031347.1
ID: 83516
Peroxisome proliferator activated receptor gamma, coactivator 1 alpha(Ppargc1) 0.738155
(p = 0.120955)
Ppargc1b
Acc: NM_176075.2
ID: 291567
Peroxisome proliferator activated receptor, coactivator 1 beta (PGC1beta, Perc) 0.969931
(p = 0.815666)
1.534911↑
(p = 0.012486)
Srebf1
Acc: XM_213329.5
XM_001075680.2
ID: 78968
Sterol regulatory element binding transcription factor 1 (ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1) 1.604384↑
(p = 0.000000)
and
1.456690↑
(p = 0.001744)
0.8782
(p = 0.125948)
and
0.934259
(p = 0.479001)
Srebf2
Acc: NM_001033694.1
ID: 300095
Sterol regulatory element binding transcription factor 2 (SREBP-2, SREBP2-retired, Srebf2) 0.732025↓
(p = 0.000761)
1.071545
(p = 0.478687)
Xbp1
Acc: NM_001004210.1
ID: 289754
X-box binding protein 1 (HTF) 1.148942
(p = 0.076252)
0.807070↓
(p = 0.016697)