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Table 1 Hepatic genes responsive to feeding of a high-fructose diet (HFrD) or HFrD supplemented with NDGA (HFrD-NDGA)

From: Microarray analysis of gene expression in liver, adipose tissue and skeletal muscle in response to chronic dietary administration of NDGA to high-fructose fed dyslipidemic rats

Gene symbol/GenBank accession/Gene ID

Entrez gene name

HFrD/Chow (Fold-change)

HFrD-NDGA/HFrD (Fold-change)

 

Fatty Acid Transport

  

Slc27a1

Acc: NM_053580.2

ID: 94172

Soluble carrier family 27 (fatty acid transporter), member 1 (FATP1)

0.817382

(p = 0.050249)

1.085686

(p = 0.548792)

Slc27a2

Acc: NM_031736.1

ID: 65192

Soluble carrier family 27 (fatty acid transporter), member 2 (FATP2)

1.276261↑

(p = 0.017602)

1.071673

(p = 0.458057)

 

Acyl-CoA Synthetases

  

Acsl1

Acc: NM_012820.1

ID: 25288

Acyl-CoA synthetase long-chain family member 1 (ACS, Acas, COAA, Facl2)

1.058003

(p = 0.59888)

1.286236↑

(p = 0.015343)

Acsl4

Acc: NM_053623.1

ID: 113976

Acyl-CoA synthetase long-chain family member 4 (ACS4, Facl4)

1.673512↑

(p = 0.000004)

0.697139↓

(p = 0.001224)

Acsm3

Acc: NM_033231.1

ID: 24763

Acyl-CoA synthetase medium-chain family member 3 (Sa, Sah)

0.458851↓

(p = 0.000004)

1.583156↑

(p = 0.000039)

Acss2

Acc: NM_001107793.1

ID: 311569

Acyl-CoA synthetase short chain family member 2 (Acss2)

1.640823↑

(p = 5.92E-09)

0.707869↓

(p = 0.000022)

 

Fatty Acid Oxidation

  

Cpt1a

Acc: NM_031559.2

ID: 25757

Carnitine palmitoyltransferase 1a, liver (CPT-1a)

2.093217↑

(p = 0.000002)

0.935127

(p = 0.569094)

Cpt1b

Acc: NM_013200.1

ID: 25756

Carnitine palmitoyltransferase 1b, muscle (CPT-1B, M-CPT1)

0.955041

(p = 0.714963)

4.901597↑

(p = 1.32E-23)

Cpt1c

Acc: NM_001034925.2

ID: 308579

Carnitine palmitoyltransferase 1c (CPT 1C, CPT1-B, CPTI-B)

0.786901

(p = 0.063481)

0.809912

(p = 0.13046)

Cpt2

Acc: NM_012930.1

ID: 25413

Carnitine palmitoyltransferase 2 (CPTII)

1.119695

(p = 0.344743)

2.583082↑

(p = 1.88E-16)

Acox1

Acc: NM_017340.2

ID: 506811

Acyl-CoA oxidase, palmitoyl (Rat ACOA1)

1.116564

(p = 0.176539)

3.27028↑

(p = 5.20E-32)

Acadl

Acc: NM_012819.1

ID: 25287

Acyl-CoA dehydrogenase, long chain (ACOADA, LCAD)

1.156082

(p = 0.178078)

1.023617

(p = 0.843391)

Acadm

Acc: NM_016986.2

ID: 24158

Acyl-CoA dehydrogenase, C-4 to C-12 straight chain (MCAD)

0.871033

(p = 0.206145)

1.171654

(p = 0.099023)

Acads

Acc: NM_022512.1

ID: 64304

Acyl-Coa dehydrogenase, C-2 to C-3 short chain (Scad)

1.125432

(p = 0.554859)

0.919627

(p = 0.563538)

Acadsb

Acc: NM_013084.1

ID: 25618

Acyl-CoA dehydrogenase, short/branched chain

1.060392

(p = 0.645381)

0.700742↓

(p = 0.030057)

Acadvl

Acc: NM_012891.1

ID: 25363

Acyl-CoA dehydrogenase very long chain (VLCAD)

1.034174

(p = 0.763361)

1.322826↑

(p = 0.003236)

Eci1

Acc: NM_017306.4

ID: 29740

Enoyl-CoA delta isomerase 1(Deci)

0.991668

(p = 0.91246)

2.461649↑

(p = 1.48E-11)

Echs1

Acc: NM_078623.2

ID: 140547

Enoy-CoA hydratase, short chain 1, mitochondrial

1.001718

(p = 0.984367)

0.982888

(p = 0.872986)

Ehhadh

Acc: NM_133606.1

ID: 171142

Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase

1.159127

(p = 0.181858)

5.837078↑

(p = 2.67E-36)

Eci2

Acc: NM_001006966.1

ID:291075

Enoyl-CoA delta isomerase 2 (Peci)

1.109171

(p = 0.294883)

1.04819

(p = 0.563012)

 

Fatty Acid Synthesis/ De Novo Lipogenesis

  

Gckr

Acc: NM_013120.2

ID: 25658

Glucokinase (hexokinase 4) regulator (GLRE)

1.225835↑

(p = 0.00735)

0.842312↓

(p = 0.029236)

Gck

Acc: NM_012565.1

ID: 24385

Glukokinase (GLUKA, RNGK2)

1.954322↑

(p = 2.09E-18)

0.6409↓

(p = 9.91E-08)

Pklr

Acc: NM_012624.3

ID: 24651

Pyruvate kinase, liver and RBC

(PK1, PKL, Pklg)

2.101247↑

(p = 0.013312)

0.763246

(p = 0.331269)

Acly

Acc: NM_016987.2

NM_001111095.1

ID: 24159

ATP citrate lyase (ACL, Clatp)

3.860112↑

(p = 8.66E-38)

0.669940↓

(p = 0.000006)

Fasn

Acc: NM_01332.1

ID: 50761

Fatty acid synthase

8.556156↑

(p = 00E + 00)

0.448329↓

(p = 2.08E-16)

Me1

Acc: NM_012600.2

ID: 24552

Malic enzyme 1, NADP(+)-dependent, cytosolic (MOD1)

8.437617↑

(p = 2.81E-20)

1.132866

(p = 0.447740)

Me2

Acc: NM_001111095.1

ID: 307270

Malic enzyme 2, NAD(+)-dependent, mitochondrial

—

—

Scd1

Acc: NM_139192.2

ID: 246074

Stearyol-Coenzyme A desaturase 1

9.689369↑

(p = 1.82E-38)

0.563616↓

(p = 3.64E-11)

Elovl1

Acc: NM_001044275.1

ID: 67953.2

ELOVL fatty acid elongase 1

0.996626

(p = 0.968014)

and

0.943940

(p = 0.460163)

0.956685

(p = 0.573719)

and

1.033276

(p = 0.664855)

Elovl2

Acc: NM_001109118.1

ID: 498728

ELOVL fatty acid elongase 2

2.461290↑

(p = 6.36E-19)

0.498430↓

(p = 3.66E-11)

Elovl4

Acc: NM_001191796.1 XM_001062735.2

ID: 315851

ELOVL fatty acid elongase 4

0.823072

(p = 0.428065)

1.658203↑

(p = 0.022936)

Elovl5

Acc: NM_134382.1

ID: 171400

ELOVL fatty acid elongase 5 (rELO1)

1.898944↑

(p = 1.23E-11)

0.416035↓

(p = 1.73E-17)

Elovl6

Acc: NM_134383.2

ID: 171402

ELOVL fatty acid elongase 6 (Lce2, rELO2)

9.009938↑

(p = 0.00E + 00)

and

2.808326↑

(p = 5.04E-11)

1.516732↑

(p = 6.34E-09)

and

1.466229↑

(p = 0.000012)

Fads1

Acc: NM_053445.2

ID: 84575

Fatty acid desaturase 1

1.241893↑

(p = 0.044164)

0.760081↓ (p = 0.006978)

Fads2

Acc: NM_031344.2

ID: 83512

Fatty acid desaturase 2 (Fadsd6)

2.161421↑ (p = 8.64E-12)

0.699797↓ (p = 0.000734)

Mlcyd

Acc: NM_053477.1

ID: 85239

Malonyl-CoA decarboxylase

1.018118

(p = 0.862908)

1.421141↑

(p = 0.000017)

 

Triglyceride (TG) Synthesis/VLDL-TG Assembly

  

Agpat1

Acc: NM_212458.1

ID: 406165

1-Acylglycerol-3-phosphate O-acyltransferase 1

0.695809↓

(p = 0.00083)

0.906865

(p = 0.595394)

Agpat2

Acc: NM_001107821.1

ID: 311821

1-Acylglycerol-3-phosphate O-acyltransferase 2

0.846901

(p = 0.109629)

1.048686

(p = 0.622341)

Agpat3

Acc: NM_001106378.1

ID: 311821

1-Acylglycerol-3-phosphate O-acyltransferase 3

0.848841

(p = 0.540663)

0.895847

(p = 0.800248)

Agpat6

Acc: NM_001047849.1

ID: 305166

1-Acylglycerol-3-phosphate O-acyltransferase 6 (RGD1310520)

1.024470

(p = 0.740343)

0.977072

(p = 0.773786)

Agpat9

Acc: NM_001025670.1

ID: 305166

1-Acylglycerol-3-phosphate O-acyltransferase 9

─

─

Mogat1

Acc: NM_001108803.1

ID: 363261

Monoacylglycerol O-acyltransferase 1

0.682029

(p = 0.154868)

1.75896↑

(p = 0.030197)

Dgat1

Acc: NM_053437.1

ID: 84497

Diacylglycerol O-acyltransferase 1 (ARAT, Dgat)

1.222808↑

(p = 0.030522)

1.067215

(p = 0.527579)

Dgat2

Acc: NM_001012345.1

ID: 252900

Diacylglycerol O-acyltransferase 2 (ARAT)

1.171782

(p = 0.67572)

0.664628↓

(p = 0.000124)

Arf3

Acc: NM_080904.2

ID: 140940

ADP-ribosylation factor 3 (AC1-253) Cholesterol Synthesis/Metabolism

1.046754

(p = 0.67572)

0.743228↓

(p = 0.001530)

 

Cholesterol Synthesis/Metabolism

  

Acat2

Acc: NM_001006995.1

ID: 308100

Acetyl-CoA acetyltransferase 2 (Acat3, Ab2-076)

0.944516

(p = 0.461984)

0.957373

(p = 0.56688)

Hmgcr

Acc: NM_013134.2

ID: 25675

3-Hydroxy-3-methylglutaryl-CoA reductase (3H3M)

1.438208↑

(p = 0.000036)

0.735862↓

(p = 0.002838)

Insig 1

Acc: NM_022392.1

ID: 64194

Insulin induced gene 1

2.844270↑

(p = 9.18E-16)

0.542157↓

(p = 0.000001)

Insig 2

Acc: NM_178091.4

ID: 288985

Insulin induced gene 2

0.831160↓

(p = 0.044277)

0.630641↓

(p = 8.36E-09)

Ldlr

Acc: NM_175762.2

ID: 300438

Low density lipoprotein receptor (LDLRA)

1.439569↑

(p = 0.003984)

0.840219

(p = 0.137488)

Mvk

Acc: NM_031063.1

ID: 81727

Mevalonate kinase (Lrbp)

0.663626↓

(p = 0.000016)

1.149403

(p = 0.234165)

Scap

Acc: NM_001100966.1

ID: 301024

SREBF chaperone Proteins Involved in Lipid Clearance

1.171144↑

(p = 0.035192)

0.995421

(p = 0.941247)

 

Proteins Involved in Lipid Clearance

  

Abca4

Acc: NM_00110772.1

ID: 310836

ATP-binding cassette, subfamily A (ABC1), member 4 (ABCR)

─

─

Abcb4

Acc: NM_012690.1

ID: 24891

ATP-binding cassette, subfamily B (MDR/TAP), member 4 (Mdr2, Pgy3)

0.489385↓

(p = 3.69E-12)

1.099759

(p = 0.27820)

Abcb11

Acc: NM_031760.1

ID: 83569

ATP-binding cassette, subfamily B (MDR/TAP), member 11 (Bsep, Spgp)

0.752953↓

(p = 0.001332)

1.158787

(p = 0.07294)

Abcc3

Acc: NM_080581.1

ID: 140668

ATP-binding cassette, subfamily C (CFTR/MRP), member 3 (Mlp2, Mrp3)

0.813337

(p = 0.08045)

2.659410↑

(p = 7.16E-11)

Abcc6

Acc: NM_031013.1

ID: 81642

ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Mrp6)

1.085723

(p = 0.31384)

0.717441↓

(p = 0.00001)

Abcd1

Acc: NM_001108821.1

ID: 363516

ATP-binding cassette, subfamily D (ALD), member 3 (RGD1562128)

1.087157

(p = 0.468224)

0.943107

(p = 0.56163)

Abcd3

Acc: NM_012804.1

ID: 25270

ATP-binging cassette, subfamily D (ALD), member 3 (PMP70, Pxmp1)

1.178867↑

(p = 0.035741)

2.15542↑

(p = 2.62E-16)

Abcg2

Acc: NM_181381.2

ID: 312382

ATP-binding cassette, subfamily G (WHITE), member 2 (BCRP1)

1.940981↑

(p = 0.000000)

1.140117

(p = 0.258891)

Abcg5

Acc: NM_053754.2

ID: 114628

ATP-binding cassette, subfamily G (WHITE), member 5

0.297237↓

(p = 5.23E-28)

3.499936↑

(p = 5.81E-28)

Apoa4

Acc: NM_012737.1

ID: 25080

Apolipoprotein A-IV (Apo-AIV, ApoA-IV, ApoAIV)

1.316723↑

(p = 0.025675)

0.447885↓

(p = 1.8E-10)

Apob

Acc: NM_019287.2

ID: 54225

Apolipoprotein B (Aa1064, AC1-060, Apo B-100, ApoB-100, ApoB-48)

0.895361

(p = 0.277000)

1.130493

(p = 0.142599)

Apoc2

Acc: NM_001085352.1

ID: 292697

Apolipoprotein C-II (RGD1560725)

0.981675

(p = 0.864333)

0.941418

(p = 0.591544)

Apoc3

Acc: NM_012501.1

ID: 24207

Apolipoprotein C-III (ApoC-III, apo-CIII)

0.887282

(p = 0.221273)

1.133806

(p = 0.221176)

Apoe

Acc: NM_138828.2

ID: 25728

Apolipoprotein E (APOEA)

0.953286

(p = 0.543392)

0.968783

(p = 0.800654)

Apof

Acc: NM_001024351.1

ID: 500761

Apolipoprotein F

1.053397

(p = 0.630710)

0.558207↓

(p = 0.000001)

Lpl

Acc: NM_012498.2

ID: 24539

Lipoprotein lipase

1.300129↑

(p = 0.024577)

3.799195↑

(p = 1.34E-16)

Vldlr

Acc: NM_013155.2

ID: 25696

Very low density lipoprotein receptor

0.993145

(p = 0.973839)

Or

1.103786

(p = 0.800081)

1.615341↑

(p = 0.012976)

Or

1.454645

(p = 0.304421)

Ppt1

Acc: NM_022502.2

ID: 29411

Palmitoyl-protein thioesterase 1 (Ppt)

1.055246

(p = 0.5199114)

0.882921

(p = 0.192733)

 

Central Metabolic Regulators (Lipid Transcription Factors)

  

Foxa1

Acc: NM_012742.1

ID: 25098

Forkhead box A1

1.489049↑

(p = 0.001314)

Or

1.271372↑

(p = 037977)

0.831777

(p = 0.136951)

Or

0.645434↓

(p = 0.000052)

Hnf4a

Acc: NM_022180.1

ID: 25735

Hepatocyte nuclear factor 4, alpha (Hnf4alpha, Hnf4a)

0.912061

(p = 0.377142)

1.357585↑

(p = 0.003965)

Mlxipl

Acc: NM_133552.1

ID: 171078

MLX interacting protein-like (ChREBP, WS-bHLH, Wbscr14, bHLHd14)

1.976840↑

(p = 1.9E-15)

0.724559↓

(p = 0.000044)

Nr1h3

Acc: NM_031627.2

ID: 58852

Nuclear receptor subfamily 1, group H, member 3 (LXRalpha)

0.980054

(p = 0.831777)

1.208346↑

(p = 0.041273)

Ppara

Acc: NM_013196.1

ID: 25747

Peroxisome proliferator activated receptor alpha (PPAR)

1.009554

(p = 0.946257)

1.760026↑

(p = 0.000067)

Ppard

Acc: NM_013141.2

ID: 25682

Peroxisome proliferator activated receptor delta (Pparb)

0.843786

(p = 0.226207)

and

1.189417

(p = 0.204488)

0.753122

(p = 0.144411)

and

0.635361↓

(p = 0.029129

Pparg

Acc: NM_013124.3

NM_001145366.1

NM_001145367.1

ID: 25664

Peroxisome proliferator activated receptor gamma

1.010459

(p = 0.879959)

1.03214

(p = 0.742011)

Ppargc1a

Acc: NM_031347.1

ID: 83516

Peroxisome proliferator activated receptor gamma, coactivator 1 alpha(Ppargc1)

0.738155

(p = 0.120955)

─

Ppargc1b

Acc: NM_176075.2

ID: 291567

Peroxisome proliferator activated receptor, coactivator 1 beta (PGC1beta, Perc)

0.969931

(p = 0.815666)

1.534911↑

(p = 0.012486)

Srebf1

Acc: XM_213329.5

XM_001075680.2

ID: 78968

Sterol regulatory element binding transcription factor 1 (ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1)

1.604384↑

(p = 0.000000)

and

1.456690↑

(p = 0.001744)

0.8782

(p = 0.125948)

and

0.934259

(p = 0.479001)

Srebf2

Acc: NM_001033694.1

ID: 300095

Sterol regulatory element binding transcription factor 2 (SREBP-2, SREBP2-retired, Srebf2)

0.732025↓

(p = 0.000761)

1.071545

(p = 0.478687)

Xbp1

Acc: NM_001004210.1

ID: 289754

X-box binding protein 1 (HTF)

1.148942

(p = 0.076252)

0.807070↓

(p = 0.016697)