Skip to main content

Table 2 Skeletal muscle genes responsive to feeding of a high-fructose diet (HFrD) or HFrD supplemented with NDGA (HFrD-NDGA)

From: Microarray analysis of gene expression in liver, adipose tissue and skeletal muscle in response to chronic dietary administration of NDGA to high-fructose fed dyslipidemic rats

Gene symbol/GenBank accession/Gene ID

Entrez gene name

HFrD/Chow (Fold-change)

HFrD-NDGA/HFrD (Fold-change)

 

Fatty Acid Transport

  

Slc27a1

Acc: NM_053580.2

ID: 94172

Soluble carrier family 27 (fatty acid transporter), member 1 (FATP1)

1.163926

(p = 0.067083)

0.603296↓

(p = 0.000002)

Slc27a2

Acc: NM_031736.1

ID: 65192

Soluble carrier family 27 (fatty acid transporter), member 2 (FATP2)

0.8357

(p = 0.727766)

6.826838↑

(p = 7.06E-28)

 

Acyl-CoA Synthetases

  

Acsl1

Acc: NM_012820.1

ID: 25288

Acyl-CoA synthetase long-chain family member 1 (ACS, Acas, COAA, Facl2)

0.929637

(p = 0.400503)

0.818346↓

(p = 0.04231)

Acsl4

Acc: NM_053623.1

ID: 113976

Acyl-CoA synthetase long-chain family member 4 (ACS4, Facl4)

1.060922

(p = 0.54153)

1.353734

(p = 0.125592)

Acsm3

Acc: NM_033231.1

ID: 24763

Acyl-CoA synthetase medium-chain family member 3 (Sa, Sah)

1.134565

(p = 0.63539)

1.518789

(p = 0.055276)

Acss2

Acc: NM_001107793.1

ID: 311569

Acyl-CoA synthetase short chain family member 2 (Acss2)

1.011241

(p = 0.898282)

1.280275↑

(p = 0.002825)

 

Fatty Acid Oxidation

  

Cpt1a

Acc: NM_031559.2

ID: 25757

Carnitine palmitoyltransferase 1a, liver (CPT-1a)

1.067497

(p = 0.448414)

0.449902↓

(p = 5.12E-08)

Cpt1b

Acc: NM_013200.1

ID: 25756

Carnitine palmitoyltransferase 1b, muscle (CPT-1B, M-CPT1)

0.828098↓

(p = 0.041576)

0.715237↓

(p = 0.000001)

Cpt1c

Acc: NM_001034925.2

ID: 308579

Carnitine palmitoyltransferase 1c (CPT 1C, CPT1-B, CPTI-B)

1.086711

(p = 0.58947)

1.392775↑

(p = 0.007650)

Cpt2

Acc: NM_012930.1

ID: 25413

Carnitine palmitoyltransferase 2 (CPTII)

1.095366

(p = 0.319692)

0.935788

(p = 0.459054)

Acox1

Acc: NM_017340.2

ID: 506811

Acyl-CoA oxidase, palmitoyl (RATACOA1)

0.942485

(p = 0.405327)

1.239981↑

(p = 0.026649)

Acadl

Acc: NM_012819.1

ID: 25287

Acyl-CoA dehydrogenase, long chain (ACOADA, LCAD)

1.038506

(p = 0.607105)

0.897447

(p = 0.286828)

Acadm

Acc: NM_016986.2

ID: 24158

Acyl-CoA dehydrogenase, C-4 to C-12 straight chain (MCAD)

1.018954

(p = 0.786051)

1.120494

(p = 0.185916)

Acads

Acc: NM_022512.1

ID: 64304

Acyl-Coa dehydrogenase, C-2 to C-3 short chain (Scad)

0.947987

(p = 0.686716)

1.163831

(p = 0.106741)

Acadsb

Acc: NM_013084.1

ID: 25618

Acyl-CoA dehydrogenase, short/branched chain

0.767644

(p = 0.056663)

1.578611↑

(p = 0.000470)

Acadvl

Acc: NM_012891.1

ID: 25363

Acyl-CoA dehydrogenase very long chain (VLCAD)

1.023041

(p = 0.81081)

1.104065

(p = 0.242381)

Eci1

Acc: NM_017306.4

ID: 29740

Enoyl-CoA delta isomerase 1(Deci)

1.028304

(p = 0.734099)

1.203436↑

(p = 0.11201)

Echs1

Acc: NM_078623.2

ID: 140547

Enoy-CoA hydratase, short chain 1,

mitochondrial

0.890438

(p = 0.269622)

0.970797

(p = 0.801854)

Ehhadh

Acc: NM_133606.1

ID: 171142

Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase

1.255433↑

(p = 0.004941)

4.521567↑

(p = 1.81E-20)

Eci2

Acc: NM_001006966.1

ID:291075

Enoyl-CoA delta isomerase 2 (Peci)

0.899414

(p = 0.120824)

0.74287↓

(p = 0.000344)

 

Fatty Acid Synthesis/ De Novo Lipogenesis

  

Gckr

Acc: NM_013120.2

ID: 25658

Glucokinase (hexokinase 4) regulator (GLRE)

1.07709

(p = 0.694603)

2.031414↑

(p = 0.00004)

Gck

Acc: NM_012565.1

ID: 24385

Glukokinase (GLUKA, RNGK2)

0.959106

(p = 0.801909)

1.706245↑

(p = 0.000131)

Pklr

Acc: NM_012624.3

ID: 24651

Pyruvate kinase, liver and RBC (PK1, PKL, Pklg)

1.013481

(p = 0.932088)

1.252908

(p = 0.073772)

Acly

Acc: NM_016987.2

NM_001111095.1

ID: 24159

ATP citrate lyase (ACL, Clatp)

0.998949

(p = 0.98697)

0.737265↓

(p = 0.000026)

Fasn

Acc: NM_01332.1

ID: 50761

Fatty acid synthase

0.706952↓

(p = 0.000244)

0.930935

(p = 0.545657)

Me1

Acc: NM_012600.2

ID: 24552

Malic enzyme 1, NADP(+)-dependent, cytosolic (MOD1)

0.822072

(p = 0.082114)

1.1122701

(p = 0.365453)

Me2

Acc: NM_001111095.1

ID: 307270

Malic enzyme 2, NAD(+)-dependent, mitochondrial

—

—

Scd1

Acc: NM_139192.2

ID: 246074

Stearyol-Coenzyme A desaturase 1

1.31285↑

(p = 0.002357)

0.761013

(p = 0.065913)

Elovl1

Acc: NM_001044275.1

ID: 67953.2

ELOVL fatty acid elongase 1

1.011133

(p = 0.897404)

and

0.943484

(p = 0.539378)

0.639064↓

(p = 5.49E-08)

and

0.584865↓

(p = 0.000002)

Elovl2

Acc: NM_001109118.1

ID: 498728

ELOVL fatty acid elongase 2

2.709103

(p = 0.626956)

1.216575

(p = 0.73873)

Elovl4

Acc: NM_001191796.1

XM_001062735.2

ID: 315851

ELOVL fatty acid elongase 4

0.831144

(p = 0.17275)

0.905935

(p = 0.619544)

Elovl5

Acc: NM_134382.1

ID: 171400

ELOVL fatty acid elongase 5 (rELO1)

0.732669↓

(p = 0.000051)

0.768796↓

(p = 0.002744)

Elovl6

Acc: NM_134383.2

ID: 171402

ELOVL fatty acid elongase 6

(Lce2, rELO2)

1.034949

(p = 0.742391)

and

0.974533

(p = 0.82477)

0.993401

(p = 0.969926)

and

1.246617

(p = 0.381630)

Fads1

Acc: NM_053445.2

ID: 84575

Fatty acid desaturase 1

1.241893↑

(p = 0.044164)

0.760080↓

(p = 0.006978)

Fads2

Acc: NM_031344.2

ID: 83512

Fatty acid desaturase 2 (Fadsd6)

2.161421↑

(p = 8.64E-12)

0.699797↓

(p = 0.000734)

Mlcyd

Acc: NM_053477.1

ID: 85239

Malonyl-CoA decarboxylase

1.050798

(p = 0.506797)

0.988309

(p = 0.909295)

 

Triglyceride (TG) Synthesis/VLDL-TG Assembly

  

Agpat1

Acc: NM_212458.1

ID: 406165

1-Acylglycerol-3-phosphate O-acyltransferase 1

0.992486

(p = 0.954388)

1.306654↑

(p = 0.038298)

Agpat2

Acc: NM_001107821.1

ID: 311821

1-Acylglycerol-3-phosphate O-acyltransferase 2

1.090764

(p = 0.284579)

0.732075↓

(p = 0.001118)

Agpat3

Acc: NM_001106378.1

ID: 311821

1-Acylglycerol-3-phosphate O-acyltransferase 3

0.943450

(p = 0.5559170)

0.954861

(p = 0.819498)

Agpat6

Acc: NM_001047849.1

ID: 305166

1-Acylglycerol-3-phosphate O-acyltransferase 6 (RGD1310520)

0.976834

(p = 0.754188)

1.114009

(p = 0.256854)

Agpat9

Acc: 001025670.1

ID: 305166

1-Acylglycerol-3-phosphate O-acyltransferase 9

0.753988↓

(p = 0.002922)

0.791921

(p = 0.185478)

Mogat1

Acc: NM_001108803.1

ID: 363261

Monoacylglycerol O-acyltransferase

1

0.875509

(p = 0.391965)

0.592216↓

(p = 0.000892)

Dgat1

Acc: NM_053437.1

ID: 84497

Diacylglycerol O-acyltransferase 1 (ARAT, Dgat)

0.928218

(p = 0.359588)

1.485906↑

(p = 0.000110)

Dgat2

Acc: NM_001012345.1

ID: 252900

Diacylglycerol O-acyltransferase 2 (ARAT)

0.911253

(p = 0.262778)

1.451837↑

(p = 0.000067)

Arf3

Acc: NM_080904.2

ID: 140940

ADP-ribosylation factor 3 (AC1-253)

1.119282

(p = 0.211709)

0.530910↓

(p = 8.33E-12)

 

Cholesterol Synthesis/Metabolism

  

Acat2

Acc: NM_001006995.1

ID: 308100

Acetyl-CoA acetyltransferase 2 (Acat3, Ab2-076)

0.952536

(p = 0.440569)

0.989649

(p = 0.940796)

Hmgcr

Acc: NM_013134.2

ID: 25675

3-Hydroxy-3-methylglutaryl-CoA reductase (3H3M)

1.070248

(p = 0.412922)

0.663322↓

(p = 0.008738)

Insig 1

Acc: NM_022392.1

ID: 64194

Insulin induced gene 1

1.242984↑

(p = 0.031151)

1.549161↑

(p = 0.003666)

Insig 2

Acc: NM_178091.4

ID: 288985

Insulin induced gene 2

0.864261

(p = 0.073905)

1.265492

(p = 0.070329)

Ldlr

Acc: NM_175762.2

ID: 300438

Low density lipoprotein receptor

(LDLRA)

0.994617

(p = 0.974217)

0.996123

(p = 0.972744)

Mvk

Acc: NM_031063.1

ID: 81727

Mevalonate kinase (Lrbp)

1.014383

(p = 0.892250)

1.129775

(p = 0.245258)

Npc1

Acc:

NM_001002025.11

ID: 266732

Niemann-Pick disease, type C1

(Cdig2)

1.002647

(p = 998400)

0.806589

(p = 0.314930)

 

Proteins Involved in Lipid Clearance

  

Abca4

Acc: NM_00110772.1

ID: 310836

ATP-binding cassette, subfamily A (ABC1), member 4 (ABCR)

─

─

Abcb4

Acc: NM_012690.1

ID: 24891

ATP-binding cassette, subfamily B (MDR/TAP), member 4 (Mdr2, Pgy3)

1.001665

(p = 0.990316)

1.352659↑

(p = 0.002415)

Abcb11

Acc: NM_031760.1

ID: 83569

ATP-binding cassette, subfamily B (MDR/TAP), member 11 (Bsep, Spgp)

0.976717

(p = 0.887315)

2.314507↑

(p = 0.000044)

Abcc3

Acc: NM_080581.1

ID: 140668

ATP-binding cassette, subfamily C (CFTR/MRP), member 3 (Mlp2, Mrp3)

1.13094

(p = 0.112959)

0.554283↓

(p = 3.47E-08)

Abcc6

Acc: NM_031013.1

ID: 81642

ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Mrp6)

1.016698

(p = 0.931493)

2.173900↑

(p = 0.000012)

Abcd1

Acc: NM_001108821.1

ID: 363516

ATP-binding cassette, subfamily D (ALD), member 3 (RGD1562128)

0.966064

(p = 0.685132)

1.009964

(p = 0.42331)

Abcd3

Acc: NM_012804.1

ID: 25270

ATP-binging cassette, subfamily D (ALD), member 3 (PMP70, Pxmp1)

1.071230

(p = 0.315252)

1.178834

(p = 0.074443)

Abcg2

Acc: NM_181381.2

ID: 312382

ATP-binding cassette, subfamily G (WHITE), member 2 (BCRP1)

0.940064

(p = 0.737683)

─

Abcg5

Acc: NM_053754.2

ID: 114628

ATP-binding cassette, subfamily G (WHITE), member 5

0.980266

(p = 0.916333)

0.810473

(p = 506217)

Apoa4

Acc: NM_012737.1

ID: 25080

Apolipoprotein A-IV (Apo-AIV, ApoA-IV, ApoAIV)

0.886124

(p = 637386)

1.397129

(p = 0.121159)

Apob

Acc: NM_019287.2

ID: 54225

Apolipoprotein B (Aa1064, AC1-060, Apo B-100, ApoB-100, ApoB-48)

0.726099

(p = 0.275237)

5.457586↑

(p = 5.48E-13)

Apoc2

Acc: NM_001085352.1

ID: 292697

Apolipoprotein C-II (RGD1560725)

0.935620

(p = 0.636398)

3.570020↑

(p = 2.22E-17)

Apoc3

Acc: NM_012501.1

ID: 24207

Apolipoprotein C-III (ApoC-III, apo-CIII)

0.912894

(p = 0.302897)

8.022169↑

(p = 6.3E-25)

Apoe

Acc: NM_138828.2

ID: 25728

Apolipoprotein E (APOEA)

1.177138

(p = 0.066475)

0.419997↓

(p = 1.01E-13)

Apof

Acc: NM_001024351.1

ID: 500761

Apolipoprotein F

─

─

Lpl

Acc: NM_012498.2

ID: 24539

Lipoprotein lipase

0.985218

(p = 0.852647)

0.543580↓

(p = 4.93E-12)

Vldlr

Acc: NM_013155.2

ID: 25696

Very low density lipoprotein receptor

1.062438

(p = 0.461893)

Or

0.888362

(p = 0.228697)

1.091786

(p = 0.205328)

Or

1.200139↑

(p = 0.030468)

Ppt1

Acc: NM_022502.2

ID: 29411

Palmitoyl-protein thioesterase 1 (Ppt)

0.959614

(p = 0.555592)

0.505612↓

(p = 5.61E-15)

(p = 0.192733)

 

Central Metabolic Regulators (Lipid Transcription Factors)

  

Foxa1

Acc: NM_012742.1

ID: 25098

Forkhead box A1

0.861648

(p = 0.59303)

0.790538

(p = 0.286379)

Hnf4a

Acc: NM_022180.1

ID: 25735

Hepatocyte nuclear factor 4, alpha (Hnf4alpha, Hnf4a)

0.969862

(p = 0.899345)

0.897382

(p = 0.784789)

Mlxipl

Acc: NM_133552.1

ID: 171078

MLX interacting protein-like (ChREBP, WS-bHLH, Wbscr14, bHLHd14)

0.644817↓

(p = 1.16E-08)

0.923704

(p = 0.439391)

Nr1h3

Acc: NM_031627.2

ID: 58852

Nuclear receptor subfamily 1, group H, member 3 (LXRalpha)

1.002888

(p = 0.964985)

1.708129↑

(p = 0.000001)

Ppara

Acc: NM_013196.1

ID: 25747

Peroxisome proliferator activated receptor alpha (PPAR)

0.897809

(p = 0.394852)

2.537218↑

(p = 0.000000)

Ppard

Acc: NM_013141.2

ID: 25682

Peroxisome proliferator activated receptor delta (Pparb)

1.000165

(p = 0.998956)

and

0.991657

(p = 0.964720)

1.428902↑

(p = 0.005855)

and

1.167184

(p = 0.271325)

Pparg

Acc: NM_013124.3 NM_001145366.1

NM_001145367.1

ID: 25664

Peroxisome proliferator activated receptor gamma

0.801471↓

(p = 0.003078)

0.924624

(p = 0.447736)

Ppargc1a

Acc: NM_031347.1

ID: 83516

Peroxisome proliferator activated receptor gamma, coactivator 1 alpha (Ppargc1)

0.719326

(p = 0.192474)

1.479666

(p = 0.067544)

Ppargc1b

Acc: NM_176075.2

ID: 291567

Peroxisome proliferator activated receptor, coactivator 1 beta (PGC1beta, Perc)

1.020089

(p = 0.82730)

0.633941↓

(p = 0.001608)

Srebf1

Acc: XM_213329.5

XM_001075680.2

ID: 78968

Sterol regulatory element binding transcription factor 1 (ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1)

0.986205

(p = 0.859100)

and

1.018349

(p = 0.853102)

1.837534↑

(p = 9.10E-08)

and

1.865578↑

(p = 0.000003)

Srebf2

Acc: NM_001033694.1

ID: 300095

Sterol regulatory element binding transcription factor 2 (SREBP-2, SREBP2-retired, Srebf2)

1.028776

(p = 0.707159)

0.82597

(p = 0.471771)

Xbp1

Acc: NM_001004210.1

ID: 289754

X-box binding protein 1 (HTF)

1.055655

(p = 0.434625)

1.317409↑

(p = 0.000651)