Gene symbol/GenBank accession/Gene ID | Entrez gene name | HFrD/Chow (Fold-change) | HFrD-NDGA/HFrD (Fold-change) |
---|---|---|---|
 | Fatty Acid Transport |  |  |
Slc27a1 Acc: NM_053580.2 ID: 94172 | Soluble carrier family 27 (fatty acid transporter), member 1 (FATP1) | 1.163926 (p = 0.067083) | 0.603296↓ (p = 0.000002) |
Slc27a2 Acc: NM_031736.1 ID: 65192 | Soluble carrier family 27 (fatty acid transporter), member 2 (FATP2) | 0.8357 (p = 0.727766) | 6.826838↑ (p = 7.06E-28) |
 | Acyl-CoA Synthetases |  |  |
Acsl1 Acc: NM_012820.1 ID: 25288 | Acyl-CoA synthetase long-chain family member 1 (ACS, Acas, COAA, Facl2) | 0.929637 (p = 0.400503) | 0.818346↓ (p = 0.04231) |
Acsl4 Acc: NM_053623.1 ID: 113976 | Acyl-CoA synthetase long-chain family member 4 (ACS4, Facl4) | 1.060922 (p = 0.54153) | 1.353734 (p = 0.125592) |
Acsm3 Acc: NM_033231.1 ID: 24763 | Acyl-CoA synthetase medium-chain family member 3 (Sa, Sah) | 1.134565 (p = 0.63539) | 1.518789 (p = 0.055276) |
Acss2 Acc: NM_001107793.1 ID: 311569 | Acyl-CoA synthetase short chain family member 2 (Acss2) | 1.011241 (p = 0.898282) | 1.280275↑ (p = 0.002825) |
 | Fatty Acid Oxidation |  |  |
Cpt1a Acc: NM_031559.2 ID: 25757 | Carnitine palmitoyltransferase 1a, liver (CPT-1a) | 1.067497 (p = 0.448414) | 0.449902↓ (p = 5.12E-08) |
Cpt1b Acc: NM_013200.1 ID: 25756 | Carnitine palmitoyltransferase 1b, muscle (CPT-1B, M-CPT1) | 0.828098↓ (p = 0.041576) | 0.715237↓ (p = 0.000001) |
Cpt1c Acc: NM_001034925.2 ID: 308579 | Carnitine palmitoyltransferase 1c (CPT 1C, CPT1-B, CPTI-B) | 1.086711 (p = 0.58947) | 1.392775↑ (p = 0.007650) |
Cpt2 Acc: NM_012930.1 ID: 25413 | Carnitine palmitoyltransferase 2 (CPTII) | 1.095366 (p = 0.319692) | 0.935788 (p = 0.459054) |
Acox1 Acc: NM_017340.2 ID: 506811 | Acyl-CoA oxidase, palmitoyl (RATACOA1) | 0.942485 (p = 0.405327) | 1.239981↑ (p = 0.026649) |
Acadl Acc: NM_012819.1 ID: 25287 | Acyl-CoA dehydrogenase, long chain (ACOADA, LCAD) | 1.038506 (p = 0.607105) | 0.897447 (p = 0.286828) |
Acadm Acc: NM_016986.2 ID: 24158 | Acyl-CoA dehydrogenase, C-4 to C-12 straight chain (MCAD) | 1.018954 (p = 0.786051) | 1.120494 (p = 0.185916) |
Acads Acc: NM_022512.1 ID: 64304 | Acyl-Coa dehydrogenase, C-2 to C-3 short chain (Scad) | 0.947987 (p = 0.686716) | 1.163831 (p = 0.106741) |
Acadsb Acc: NM_013084.1 ID: 25618 | Acyl-CoA dehydrogenase, short/branched chain | 0.767644 (p = 0.056663) | 1.578611↑ (p = 0.000470) |
Acadvl Acc: NM_012891.1 ID: 25363 | Acyl-CoA dehydrogenase very long chain (VLCAD) | 1.023041 (p = 0.81081) | 1.104065 (p = 0.242381) |
Eci1 Acc: NM_017306.4 ID: 29740 | Enoyl-CoA delta isomerase 1(Deci) | 1.028304 (p = 0.734099) | 1.203436↑ (p = 0.11201) |
Echs1 Acc: NM_078623.2 ID: 140547 | Enoy-CoA hydratase, short chain 1, mitochondrial | 0.890438 (p = 0.269622) | 0.970797 (p = 0.801854) |
Ehhadh Acc: NM_133606.1 ID: 171142 | Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase | 1.255433↑ (p = 0.004941) | 4.521567↑ (p = 1.81E-20) |
Eci2 Acc: NM_001006966.1 ID:291075 | Enoyl-CoA delta isomerase 2 (Peci) | 0.899414 (p = 0.120824) | 0.74287↓ (p = 0.000344) |
 | Fatty Acid Synthesis/ De Novo Lipogenesis |  |  |
Gckr Acc: NM_013120.2 ID: 25658 | Glucokinase (hexokinase 4) regulator (GLRE) | 1.07709 (p = 0.694603) | 2.031414↑ (p = 0.00004) |
Gck Acc: NM_012565.1 ID: 24385 | Glukokinase (GLUKA, RNGK2) | 0.959106 (p = 0.801909) | 1.706245↑ (p = 0.000131) |
Pklr Acc: NM_012624.3 ID: 24651 | Pyruvate kinase, liver and RBC (PK1, PKL, Pklg) | 1.013481 (p = 0.932088) | 1.252908 (p = 0.073772) |
Acly Acc: NM_016987.2 NM_001111095.1 ID: 24159 | ATP citrate lyase (ACL, Clatp) | 0.998949 (p = 0.98697) | 0.737265↓ (p = 0.000026) |
Fasn Acc: NM_01332.1 ID: 50761 | Fatty acid synthase | 0.706952↓ (p = 0.000244) | 0.930935 (p = 0.545657) |
Me1 Acc: NM_012600.2 ID: 24552 | Malic enzyme 1, NADP(+)-dependent, cytosolic (MOD1) | 0.822072 (p = 0.082114) | 1.1122701 (p = 0.365453) |
Me2 Acc: NM_001111095.1 ID: 307270 | Malic enzyme 2, NAD(+)-dependent, mitochondrial | — | — |
Scd1 Acc: NM_139192.2 ID: 246074 | Stearyol-Coenzyme A desaturase 1 | 1.31285↑ (p = 0.002357) | 0.761013 (p = 0.065913) |
Elovl1 Acc: NM_001044275.1 ID: 67953.2 | ELOVL fatty acid elongase 1 | 1.011133 (p = 0.897404) and 0.943484 (p = 0.539378) | 0.639064↓ (p = 5.49E-08) and 0.584865↓ (p = 0.000002) |
Elovl2 Acc: NM_001109118.1 ID: 498728 | ELOVL fatty acid elongase 2 | 2.709103 (p = 0.626956) | 1.216575 (p = 0.73873) |
Elovl4 Acc: NM_001191796.1 XM_001062735.2 ID: 315851 | ELOVL fatty acid elongase 4 | 0.831144 (p = 0.17275) | 0.905935 (p = 0.619544) |
Elovl5 Acc: NM_134382.1 ID: 171400 | ELOVL fatty acid elongase 5 (rELO1) | 0.732669↓ (p = 0.000051) | 0.768796↓ (p = 0.002744) |
Elovl6 Acc: NM_134383.2 ID: 171402 | ELOVL fatty acid elongase 6 (Lce2, rELO2) | 1.034949 (p = 0.742391) and 0.974533 (p = 0.82477) | 0.993401 (p = 0.969926) and 1.246617 (p = 0.381630) |
Fads1 Acc: NM_053445.2 ID: 84575 | Fatty acid desaturase 1 | 1.241893↑ (p = 0.044164) | 0.760080↓ (p = 0.006978) |
Fads2 Acc: NM_031344.2 ID: 83512 | Fatty acid desaturase 2 (Fadsd6) | 2.161421↑ (p = 8.64E-12) | 0.699797↓ (p = 0.000734) |
Mlcyd Acc: NM_053477.1 ID: 85239 | Malonyl-CoA decarboxylase | 1.050798 (p = 0.506797) | 0.988309 (p = 0.909295) |
 | Triglyceride (TG) Synthesis/VLDL-TG Assembly |  |  |
Agpat1 Acc: NM_212458.1 ID: 406165 | 1-Acylglycerol-3-phosphate O-acyltransferase 1 | 0.992486 (p = 0.954388) | 1.306654↑ (p = 0.038298) |
Agpat2 Acc: NM_001107821.1 ID: 311821 | 1-Acylglycerol-3-phosphate O-acyltransferase 2 | 1.090764 (p = 0.284579) | 0.732075↓ (p = 0.001118) |
Agpat3 Acc: NM_001106378.1 ID: 311821 | 1-Acylglycerol-3-phosphate O-acyltransferase 3 | 0.943450 (p = 0.5559170) | 0.954861 (p = 0.819498) |
Agpat6 Acc: NM_001047849.1 ID: 305166 | 1-Acylglycerol-3-phosphate O-acyltransferase 6 (RGD1310520) | 0.976834 (p = 0.754188) | 1.114009 (p = 0.256854) |
Agpat9 Acc: 001025670.1 ID: 305166 | 1-Acylglycerol-3-phosphate O-acyltransferase 9 | 0.753988↓ (p = 0.002922) | 0.791921 (p = 0.185478) |
Mogat1 Acc: NM_001108803.1 ID: 363261 | Monoacylglycerol O-acyltransferase 1 | 0.875509 (p = 0.391965) | 0.592216↓ (p = 0.000892) |
Dgat1 Acc: NM_053437.1 ID: 84497 | Diacylglycerol O-acyltransferase 1 (ARAT, Dgat) | 0.928218 (p = 0.359588) | 1.485906↑ (p = 0.000110) |
Dgat2 Acc: NM_001012345.1 ID: 252900 | Diacylglycerol O-acyltransferase 2 (ARAT) | 0.911253 (p = 0.262778) | 1.451837↑ (p = 0.000067) |
Arf3 Acc: NM_080904.2 ID: 140940 | ADP-ribosylation factor 3 (AC1-253) | 1.119282 (p = 0.211709) | 0.530910↓ (p = 8.33E-12) |
 | Cholesterol Synthesis/Metabolism |  |  |
Acat2 Acc: NM_001006995.1 ID: 308100 | Acetyl-CoA acetyltransferase 2 (Acat3, Ab2-076) | 0.952536 (p = 0.440569) | 0.989649 (p = 0.940796) |
Hmgcr Acc: NM_013134.2 ID: 25675 | 3-Hydroxy-3-methylglutaryl-CoA reductase (3H3M) | 1.070248 (p = 0.412922) | 0.663322↓ (p = 0.008738) |
Insig 1 Acc: NM_022392.1 ID: 64194 | Insulin induced gene 1 | 1.242984↑ (p = 0.031151) | 1.549161↑ (p = 0.003666) |
Insig 2 Acc: NM_178091.4 ID: 288985 | Insulin induced gene 2 | 0.864261 (p = 0.073905) | 1.265492 (p = 0.070329) |
Ldlr Acc: NM_175762.2 ID: 300438 | Low density lipoprotein receptor (LDLRA) | 0.994617 (p = 0.974217) | 0.996123 (p = 0.972744) |
Mvk Acc: NM_031063.1 ID: 81727 | Mevalonate kinase (Lrbp) | 1.014383 (p = 0.892250) | 1.129775 (p = 0.245258) |
Npc1 Acc: NM_001002025.11 ID: 266732 | Niemann-Pick disease, type C1 (Cdig2) | 1.002647 (p = 998400) | 0.806589 (p = 0.314930) |
 | Proteins Involved in Lipid Clearance |  |  |
Abca4 Acc: NM_00110772.1 ID: 310836 | ATP-binding cassette, subfamily A (ABC1), member 4 (ABCR) | ─ | ─ |
Abcb4 Acc: NM_012690.1 ID: 24891 | ATP-binding cassette, subfamily B (MDR/TAP), member 4 (Mdr2, Pgy3) | 1.001665 (p = 0.990316) | 1.352659↑ (p = 0.002415) |
Abcb11 Acc: NM_031760.1 ID: 83569 | ATP-binding cassette, subfamily B (MDR/TAP), member 11 (Bsep, Spgp) | 0.976717 (p = 0.887315) | 2.314507↑ (p = 0.000044) |
Abcc3 Acc: NM_080581.1 ID: 140668 | ATP-binding cassette, subfamily C (CFTR/MRP), member 3 (Mlp2, Mrp3) | 1.13094 (p = 0.112959) | 0.554283↓ (p = 3.47E-08) |
Abcc6 Acc: NM_031013.1 ID: 81642 | ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Mrp6) | 1.016698 (p = 0.931493) | 2.173900↑ (p = 0.000012) |
Abcd1 Acc: NM_001108821.1 ID: 363516 | ATP-binding cassette, subfamily D (ALD), member 3 (RGD1562128) | 0.966064 (p = 0.685132) | 1.009964 (p = 0.42331) |
Abcd3 Acc: NM_012804.1 ID: 25270 | ATP-binging cassette, subfamily D (ALD), member 3 (PMP70, Pxmp1) | 1.071230 (p = 0.315252) | 1.178834 (p = 0.074443) |
Abcg2 Acc: NM_181381.2 ID: 312382 | ATP-binding cassette, subfamily G (WHITE), member 2 (BCRP1) | 0.940064 (p = 0.737683) | ─ |
Abcg5 Acc: NM_053754.2 ID: 114628 | ATP-binding cassette, subfamily G (WHITE), member 5 | 0.980266 (p = 0.916333) | 0.810473 (p = 506217) |
Apoa4 Acc: NM_012737.1 ID: 25080 | Apolipoprotein A-IV (Apo-AIV, ApoA-IV, ApoAIV) | 0.886124 (p = 637386) | 1.397129 (p = 0.121159) |
Apob Acc: NM_019287.2 ID: 54225 | Apolipoprotein B (Aa1064, AC1-060, Apo B-100, ApoB-100, ApoB-48) | 0.726099 (p = 0.275237) | 5.457586↑ (p = 5.48E-13) |
Apoc2 Acc: NM_001085352.1 ID: 292697 | Apolipoprotein C-II (RGD1560725) | 0.935620 (p = 0.636398) | 3.570020↑ (p = 2.22E-17) |
Apoc3 Acc: NM_012501.1 ID: 24207 | Apolipoprotein C-III (ApoC-III, apo-CIII) | 0.912894 (p = 0.302897) | 8.022169↑ (p = 6.3E-25) |
Apoe Acc: NM_138828.2 ID: 25728 | Apolipoprotein E (APOEA) | 1.177138 (p = 0.066475) | 0.419997↓ (p = 1.01E-13) |
Apof Acc: NM_001024351.1 ID: 500761 | Apolipoprotein F | ─ | ─ |
Lpl Acc: NM_012498.2 ID: 24539 | Lipoprotein lipase | 0.985218 (p = 0.852647) | 0.543580↓ (p = 4.93E-12) |
Vldlr Acc: NM_013155.2 ID: 25696 | Very low density lipoprotein receptor | 1.062438 (p = 0.461893) Or 0.888362 (p = 0.228697) | 1.091786 (p = 0.205328) Or 1.200139↑ (p = 0.030468) |
Ppt1 Acc: NM_022502.2 ID: 29411 | Palmitoyl-protein thioesterase 1 (Ppt) | 0.959614 (p = 0.555592) | 0.505612↓ (p = 5.61E-15) (p = 0.192733) |
 | Central Metabolic Regulators (Lipid Transcription Factors) |  |  |
Foxa1 Acc: NM_012742.1 ID: 25098 | Forkhead box A1 | 0.861648 (p = 0.59303) | 0.790538 (p = 0.286379) |
Hnf4a Acc: NM_022180.1 ID: 25735 | Hepatocyte nuclear factor 4, alpha (Hnf4alpha, Hnf4a) | 0.969862 (p = 0.899345) | 0.897382 (p = 0.784789) |
Mlxipl Acc: NM_133552.1 ID: 171078 | MLX interacting protein-like (ChREBP, WS-bHLH, Wbscr14, bHLHd14) | 0.644817↓ (p = 1.16E-08) | 0.923704 (p = 0.439391) |
Nr1h3 Acc: NM_031627.2 ID: 58852 | Nuclear receptor subfamily 1, group H, member 3 (LXRalpha) | 1.002888 (p = 0.964985) | 1.708129↑ (p = 0.000001) |
Ppara Acc: NM_013196.1 ID: 25747 | Peroxisome proliferator activated receptor alpha (PPAR) | 0.897809 (p = 0.394852) | 2.537218↑ (p = 0.000000) |
Ppard Acc: NM_013141.2 ID: 25682 | Peroxisome proliferator activated receptor delta (Pparb) | 1.000165 (p = 0.998956) and 0.991657 (p = 0.964720) | 1.428902↑ (p = 0.005855) and 1.167184 (p = 0.271325) |
Pparg Acc: NM_013124.3 NM_001145366.1 NM_001145367.1 ID: 25664 | Peroxisome proliferator activated receptor gamma | 0.801471↓ (p = 0.003078) | 0.924624 (p = 0.447736) |
Ppargc1a Acc: NM_031347.1 ID: 83516 | Peroxisome proliferator activated receptor gamma, coactivator 1 alpha (Ppargc1) | 0.719326 (p = 0.192474) | 1.479666 (p = 0.067544) |
Ppargc1b Acc: NM_176075.2 ID: 291567 | Peroxisome proliferator activated receptor, coactivator 1 beta (PGC1beta, Perc) | 1.020089 (p = 0.82730) | 0.633941↓ (p = 0.001608) |
Srebf1 Acc: XM_213329.5 XM_001075680.2 ID: 78968 | Sterol regulatory element binding transcription factor 1 (ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1) | 0.986205 (p = 0.859100) and 1.018349 (p = 0.853102) | 1.837534↑ (p = 9.10E-08) and 1.865578↑ (p = 0.000003) |
Srebf2 Acc: NM_001033694.1 ID: 300095 | Sterol regulatory element binding transcription factor 2 (SREBP-2, SREBP2-retired, Srebf2) | 1.028776 (p = 0.707159) | 0.82597 (p = 0.471771) |
Xbp1 Acc: NM_001004210.1 ID: 289754 | X-box binding protein 1 (HTF) | 1.055655 (p = 0.434625) | 1.317409↑ (p = 0.000651) |