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Table 2 Skeletal muscle genes responsive to feeding of a high-fructose diet (HFrD) or HFrD supplemented with NDGA (HFrD-NDGA)

From: Microarray analysis of gene expression in liver, adipose tissue and skeletal muscle in response to chronic dietary administration of NDGA to high-fructose fed dyslipidemic rats

Gene symbol/GenBank accession/Gene ID Entrez gene name HFrD/Chow (Fold-change) HFrD-NDGA/HFrD (Fold-change)
  Fatty Acid Transport   
Slc27a1 Acc: NM_053580.2 ID: 94172 Soluble carrier family 27 (fatty acid transporter), member 1 (FATP1) 1.163926 (p = 0.067083) 0.603296↓ (p = 0.000002)
Slc27a2 Acc: NM_031736.1 ID: 65192 Soluble carrier family 27 (fatty acid transporter), member 2 (FATP2) 0.8357 (p = 0.727766) 6.826838↑ (p = 7.06E-28)
  Acyl-CoA Synthetases   
Acsl1 Acc: NM_012820.1 ID: 25288 Acyl-CoA synthetase long-chain family member 1 (ACS, Acas, COAA, Facl2) 0.929637 (p = 0.400503) 0.818346↓ (p = 0.04231)
Acsl4 Acc: NM_053623.1 ID: 113976 Acyl-CoA synthetase long-chain family member 4 (ACS4, Facl4) 1.060922 (p = 0.54153) 1.353734 (p = 0.125592)
Acsm3 Acc: NM_033231.1 ID: 24763 Acyl-CoA synthetase medium-chain family member 3 (Sa, Sah) 1.134565 (p = 0.63539) 1.518789 (p = 0.055276)
Acss2 Acc: NM_001107793.1 ID: 311569 Acyl-CoA synthetase short chain family member 2 (Acss2) 1.011241 (p = 0.898282) 1.280275↑ (p = 0.002825)
  Fatty Acid Oxidation   
Cpt1a Acc: NM_031559.2 ID: 25757 Carnitine palmitoyltransferase 1a, liver (CPT-1a) 1.067497 (p = 0.448414) 0.449902↓ (p = 5.12E-08)
Cpt1b Acc: NM_013200.1 ID: 25756 Carnitine palmitoyltransferase 1b, muscle (CPT-1B, M-CPT1) 0.828098↓ (p = 0.041576) 0.715237↓ (p = 0.000001)
Cpt1c Acc: NM_001034925.2 ID: 308579 Carnitine palmitoyltransferase 1c (CPT 1C, CPT1-B, CPTI-B) 1.086711 (p = 0.58947) 1.392775↑ (p = 0.007650)
Cpt2 Acc: NM_012930.1 ID: 25413 Carnitine palmitoyltransferase 2 (CPTII) 1.095366 (p = 0.319692) 0.935788 (p = 0.459054)
Acox1 Acc: NM_017340.2 ID: 506811 Acyl-CoA oxidase, palmitoyl (RATACOA1) 0.942485 (p = 0.405327) 1.239981↑ (p = 0.026649)
Acadl Acc: NM_012819.1 ID: 25287 Acyl-CoA dehydrogenase, long chain (ACOADA, LCAD) 1.038506 (p = 0.607105) 0.897447 (p = 0.286828)
Acadm Acc: NM_016986.2 ID: 24158 Acyl-CoA dehydrogenase, C-4 to C-12 straight chain (MCAD) 1.018954 (p = 0.786051) 1.120494 (p = 0.185916)
Acads Acc: NM_022512.1 ID: 64304 Acyl-Coa dehydrogenase, C-2 to C-3 short chain (Scad) 0.947987 (p = 0.686716) 1.163831 (p = 0.106741)
Acadsb Acc: NM_013084.1 ID: 25618 Acyl-CoA dehydrogenase, short/branched chain 0.767644 (p = 0.056663) 1.578611↑ (p = 0.000470)
Acadvl Acc: NM_012891.1 ID: 25363 Acyl-CoA dehydrogenase very long chain (VLCAD) 1.023041 (p = 0.81081) 1.104065 (p = 0.242381)
Eci1 Acc: NM_017306.4 ID: 29740 Enoyl-CoA delta isomerase 1(Deci) 1.028304 (p = 0.734099) 1.203436↑ (p = 0.11201)
Echs1 Acc: NM_078623.2 ID: 140547 Enoy-CoA hydratase, short chain 1, mitochondrial 0.890438 (p = 0.269622) 0.970797 (p = 0.801854)
Ehhadh Acc: NM_133606.1 ID: 171142 Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase 1.255433↑ (p = 0.004941) 4.521567↑ (p = 1.81E-20)
Eci2 Acc: NM_001006966.1 ID:291075 Enoyl-CoA delta isomerase 2 (Peci) 0.899414 (p = 0.120824) 0.74287↓ (p = 0.000344)
  Fatty Acid Synthesis/ De Novo Lipogenesis   
Gckr Acc: NM_013120.2 ID: 25658 Glucokinase (hexokinase 4) regulator (GLRE) 1.07709 (p = 0.694603) 2.031414↑ (p = 0.00004)
Gck Acc: NM_012565.1 ID: 24385 Glukokinase (GLUKA, RNGK2) 0.959106 (p = 0.801909) 1.706245↑ (p = 0.000131)
Pklr Acc: NM_012624.3 ID: 24651 Pyruvate kinase, liver and RBC (PK1, PKL, Pklg) 1.013481 (p = 0.932088) 1.252908 (p = 0.073772)
Acly Acc: NM_016987.2 NM_001111095.1 ID: 24159 ATP citrate lyase (ACL, Clatp) 0.998949 (p = 0.98697) 0.737265↓ (p = 0.000026)
Fasn Acc: NM_01332.1 ID: 50761 Fatty acid synthase 0.706952↓ (p = 0.000244) 0.930935 (p = 0.545657)
Me1 Acc: NM_012600.2 ID: 24552 Malic enzyme 1, NADP(+)-dependent, cytosolic (MOD1) 0.822072 (p = 0.082114) 1.1122701 (p = 0.365453)
Me2 Acc: NM_001111095.1 ID: 307270 Malic enzyme 2, NAD(+)-dependent, mitochondrial
Scd1 Acc: NM_139192.2 ID: 246074 Stearyol-Coenzyme A desaturase 1 1.31285↑ (p = 0.002357) 0.761013 (p = 0.065913)
Elovl1 Acc: NM_001044275.1 ID: 67953.2 ELOVL fatty acid elongase 1 1.011133 (p = 0.897404) and 0.943484 (p = 0.539378) 0.639064↓ (p = 5.49E-08) and 0.584865↓ (p = 0.000002)
Elovl2 Acc: NM_001109118.1 ID: 498728 ELOVL fatty acid elongase 2 2.709103 (p = 0.626956) 1.216575 (p = 0.73873)
Elovl4 Acc: NM_001191796.1 XM_001062735.2 ID: 315851 ELOVL fatty acid elongase 4 0.831144 (p = 0.17275) 0.905935 (p = 0.619544)
Elovl5 Acc: NM_134382.1 ID: 171400 ELOVL fatty acid elongase 5 (rELO1) 0.732669↓ (p = 0.000051) 0.768796↓ (p = 0.002744)
Elovl6 Acc: NM_134383.2 ID: 171402 ELOVL fatty acid elongase 6 (Lce2, rELO2) 1.034949 (p = 0.742391) and 0.974533 (p = 0.82477) 0.993401 (p = 0.969926) and 1.246617 (p = 0.381630)
Fads1 Acc: NM_053445.2 ID: 84575 Fatty acid desaturase 1 1.241893↑ (p = 0.044164) 0.760080↓ (p = 0.006978)
Fads2 Acc: NM_031344.2 ID: 83512 Fatty acid desaturase 2 (Fadsd6) 2.161421↑ (p = 8.64E-12) 0.699797↓ (p = 0.000734)
Mlcyd Acc: NM_053477.1 ID: 85239 Malonyl-CoA decarboxylase 1.050798 (p = 0.506797) 0.988309 (p = 0.909295)
  Triglyceride (TG) Synthesis/VLDL-TG Assembly   
Agpat1 Acc: NM_212458.1 ID: 406165 1-Acylglycerol-3-phosphate O-acyltransferase 1 0.992486 (p = 0.954388) 1.306654↑ (p = 0.038298)
Agpat2 Acc: NM_001107821.1 ID: 311821 1-Acylglycerol-3-phosphate O-acyltransferase 2 1.090764 (p = 0.284579) 0.732075↓ (p = 0.001118)
Agpat3 Acc: NM_001106378.1 ID: 311821 1-Acylglycerol-3-phosphate O-acyltransferase 3 0.943450 (p = 0.5559170) 0.954861 (p = 0.819498)
Agpat6 Acc: NM_001047849.1 ID: 305166 1-Acylglycerol-3-phosphate O-acyltransferase 6 (RGD1310520) 0.976834 (p = 0.754188) 1.114009 (p = 0.256854)
Agpat9 Acc: 001025670.1 ID: 305166 1-Acylglycerol-3-phosphate O-acyltransferase 9 0.753988↓ (p = 0.002922) 0.791921 (p = 0.185478)
Mogat1 Acc: NM_001108803.1 ID: 363261 Monoacylglycerol O-acyltransferase 1 0.875509 (p = 0.391965) 0.592216↓ (p = 0.000892)
Dgat1 Acc: NM_053437.1 ID: 84497 Diacylglycerol O-acyltransferase 1 (ARAT, Dgat) 0.928218 (p = 0.359588) 1.485906↑ (p = 0.000110)
Dgat2 Acc: NM_001012345.1 ID: 252900 Diacylglycerol O-acyltransferase 2 (ARAT) 0.911253 (p = 0.262778) 1.451837↑ (p = 0.000067)
Arf3 Acc: NM_080904.2 ID: 140940 ADP-ribosylation factor 3 (AC1-253) 1.119282 (p = 0.211709) 0.530910↓ (p = 8.33E-12)
  Cholesterol Synthesis/Metabolism   
Acat2 Acc: NM_001006995.1 ID: 308100 Acetyl-CoA acetyltransferase 2 (Acat3, Ab2-076) 0.952536 (p = 0.440569) 0.989649 (p = 0.940796)
Hmgcr Acc: NM_013134.2 ID: 25675 3-Hydroxy-3-methylglutaryl-CoA reductase (3H3M) 1.070248 (p = 0.412922) 0.663322↓ (p = 0.008738)
Insig 1 Acc: NM_022392.1 ID: 64194 Insulin induced gene 1 1.242984↑ (p = 0.031151) 1.549161↑ (p = 0.003666)
Insig 2 Acc: NM_178091.4 ID: 288985 Insulin induced gene 2 0.864261 (p = 0.073905) 1.265492 (p = 0.070329)
Ldlr Acc: NM_175762.2 ID: 300438 Low density lipoprotein receptor (LDLRA) 0.994617 (p = 0.974217) 0.996123 (p = 0.972744)
Mvk Acc: NM_031063.1 ID: 81727 Mevalonate kinase (Lrbp) 1.014383 (p = 0.892250) 1.129775 (p = 0.245258)
Npc1 Acc: NM_001002025.11 ID: 266732 Niemann-Pick disease, type C1 (Cdig2) 1.002647 (p = 998400) 0.806589 (p = 0.314930)
  Proteins Involved in Lipid Clearance   
Abca4 Acc: NM_00110772.1 ID: 310836 ATP-binding cassette, subfamily A (ABC1), member 4 (ABCR)
Abcb4 Acc: NM_012690.1 ID: 24891 ATP-binding cassette, subfamily B (MDR/TAP), member 4 (Mdr2, Pgy3) 1.001665 (p = 0.990316) 1.352659↑ (p = 0.002415)
Abcb11 Acc: NM_031760.1 ID: 83569 ATP-binding cassette, subfamily B (MDR/TAP), member 11 (Bsep, Spgp) 0.976717 (p = 0.887315) 2.314507↑ (p = 0.000044)
Abcc3 Acc: NM_080581.1 ID: 140668 ATP-binding cassette, subfamily C (CFTR/MRP), member 3 (Mlp2, Mrp3) 1.13094 (p = 0.112959) 0.554283↓ (p = 3.47E-08)
Abcc6 Acc: NM_031013.1 ID: 81642 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Mrp6) 1.016698 (p = 0.931493) 2.173900↑ (p = 0.000012)
Abcd1 Acc: NM_001108821.1 ID: 363516 ATP-binding cassette, subfamily D (ALD), member 3 (RGD1562128) 0.966064 (p = 0.685132) 1.009964 (p = 0.42331)
Abcd3 Acc: NM_012804.1 ID: 25270 ATP-binging cassette, subfamily D (ALD), member 3 (PMP70, Pxmp1) 1.071230 (p = 0.315252) 1.178834 (p = 0.074443)
Abcg2 Acc: NM_181381.2 ID: 312382 ATP-binding cassette, subfamily G (WHITE), member 2 (BCRP1) 0.940064 (p = 0.737683)
Abcg5 Acc: NM_053754.2 ID: 114628 ATP-binding cassette, subfamily G (WHITE), member 5 0.980266 (p = 0.916333) 0.810473 (p = 506217)
Apoa4 Acc: NM_012737.1 ID: 25080 Apolipoprotein A-IV (Apo-AIV, ApoA-IV, ApoAIV) 0.886124 (p = 637386) 1.397129 (p = 0.121159)
Apob Acc: NM_019287.2 ID: 54225 Apolipoprotein B (Aa1064, AC1-060, Apo B-100, ApoB-100, ApoB-48) 0.726099 (p = 0.275237) 5.457586↑ (p = 5.48E-13)
Apoc2 Acc: NM_001085352.1 ID: 292697 Apolipoprotein C-II (RGD1560725) 0.935620 (p = 0.636398) 3.570020↑ (p = 2.22E-17)
Apoc3 Acc: NM_012501.1 ID: 24207 Apolipoprotein C-III (ApoC-III, apo-CIII) 0.912894 (p = 0.302897) 8.022169↑ (p = 6.3E-25)
Apoe Acc: NM_138828.2 ID: 25728 Apolipoprotein E (APOEA) 1.177138 (p = 0.066475) 0.419997↓ (p = 1.01E-13)
Apof Acc: NM_001024351.1 ID: 500761 Apolipoprotein F
Lpl Acc: NM_012498.2 ID: 24539 Lipoprotein lipase 0.985218 (p = 0.852647) 0.543580↓ (p = 4.93E-12)
Vldlr Acc: NM_013155.2 ID: 25696 Very low density lipoprotein receptor 1.062438 (p = 0.461893) Or 0.888362 (p = 0.228697) 1.091786 (p = 0.205328) Or 1.200139↑ (p = 0.030468)
Ppt1 Acc: NM_022502.2 ID: 29411 Palmitoyl-protein thioesterase 1 (Ppt) 0.959614 (p = 0.555592) 0.505612↓ (p = 5.61E-15) (p = 0.192733)
  Central Metabolic Regulators (Lipid Transcription Factors)   
Foxa1 Acc: NM_012742.1 ID: 25098 Forkhead box A1 0.861648 (p = 0.59303) 0.790538 (p = 0.286379)
Hnf4a Acc: NM_022180.1 ID: 25735 Hepatocyte nuclear factor 4, alpha (Hnf4alpha, Hnf4a) 0.969862 (p = 0.899345) 0.897382 (p = 0.784789)
Mlxipl Acc: NM_133552.1 ID: 171078 MLX interacting protein-like (ChREBP, WS-bHLH, Wbscr14, bHLHd14) 0.644817↓ (p = 1.16E-08) 0.923704 (p = 0.439391)
Nr1h3 Acc: NM_031627.2 ID: 58852 Nuclear receptor subfamily 1, group H, member 3 (LXRalpha) 1.002888 (p = 0.964985) 1.708129↑ (p = 0.000001)
Ppara Acc: NM_013196.1 ID: 25747 Peroxisome proliferator activated receptor alpha (PPAR) 0.897809 (p = 0.394852) 2.537218↑ (p = 0.000000)
Ppard Acc: NM_013141.2 ID: 25682 Peroxisome proliferator activated receptor delta (Pparb) 1.000165 (p = 0.998956) and 0.991657 (p = 0.964720) 1.428902↑ (p = 0.005855) and 1.167184 (p = 0.271325)
Pparg Acc: NM_013124.3 NM_001145366.1 NM_001145367.1 ID: 25664 Peroxisome proliferator activated receptor gamma 0.801471↓ (p = 0.003078) 0.924624 (p = 0.447736)
Ppargc1a Acc: NM_031347.1 ID: 83516 Peroxisome proliferator activated receptor gamma, coactivator 1 alpha (Ppargc1) 0.719326 (p = 0.192474) 1.479666 (p = 0.067544)
Ppargc1b Acc: NM_176075.2 ID: 291567 Peroxisome proliferator activated receptor, coactivator 1 beta (PGC1beta, Perc) 1.020089 (p = 0.82730) 0.633941↓ (p = 0.001608)
Srebf1 Acc: XM_213329.5 XM_001075680.2 ID: 78968 Sterol regulatory element binding transcription factor 1 (ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1) 0.986205 (p = 0.859100) and 1.018349 (p = 0.853102) 1.837534↑ (p = 9.10E-08) and 1.865578↑ (p = 0.000003)
Srebf2 Acc: NM_001033694.1 ID: 300095 Sterol regulatory element binding transcription factor 2 (SREBP-2, SREBP2-retired, Srebf2) 1.028776 (p = 0.707159) 0.82597 (p = 0.471771)
Xbp1 Acc: NM_001004210.1 ID: 289754 X-box binding protein 1 (HTF) 1.055655 (p = 0.434625) 1.317409↑ (p = 0.000651)