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Table 2 Skeletal muscle genes responsive to feeding of a high-fructose diet (HFrD) or HFrD supplemented with NDGA (HFrD-NDGA)

From: Microarray analysis of gene expression in liver, adipose tissue and skeletal muscle in response to chronic dietary administration of NDGA to high-fructose fed dyslipidemic rats

Gene symbol/GenBank accession/Gene ID Entrez gene name HFrD/Chow (Fold-change) HFrD-NDGA/HFrD (Fold-change)
  Fatty Acid Transport   
Slc27a1
Acc: NM_053580.2
ID: 94172
Soluble carrier family 27 (fatty acid transporter), member 1 (FATP1) 1.163926
(p = 0.067083)
0.603296↓
(p = 0.000002)
Slc27a2
Acc: NM_031736.1
ID: 65192
Soluble carrier family 27 (fatty acid transporter), member 2 (FATP2) 0.8357
(p = 0.727766)
6.826838↑
(p = 7.06E-28)
  Acyl-CoA Synthetases   
Acsl1
Acc: NM_012820.1
ID: 25288
Acyl-CoA synthetase long-chain family member 1 (ACS, Acas, COAA, Facl2) 0.929637
(p = 0.400503)
0.818346↓
(p = 0.04231)
Acsl4
Acc: NM_053623.1
ID: 113976
Acyl-CoA synthetase long-chain family member 4 (ACS4, Facl4) 1.060922
(p = 0.54153)
1.353734
(p = 0.125592)
Acsm3
Acc: NM_033231.1
ID: 24763
Acyl-CoA synthetase medium-chain family member 3 (Sa, Sah) 1.134565
(p = 0.63539)
1.518789
(p = 0.055276)
Acss2
Acc: NM_001107793.1
ID: 311569
Acyl-CoA synthetase short chain family member 2 (Acss2) 1.011241
(p = 0.898282)
1.280275↑
(p = 0.002825)
  Fatty Acid Oxidation   
Cpt1a
Acc: NM_031559.2
ID: 25757
Carnitine palmitoyltransferase 1a, liver (CPT-1a) 1.067497
(p = 0.448414)
0.449902↓
(p = 5.12E-08)
Cpt1b
Acc: NM_013200.1
ID: 25756
Carnitine palmitoyltransferase 1b, muscle (CPT-1B, M-CPT1) 0.828098↓
(p = 0.041576)
0.715237↓
(p = 0.000001)
Cpt1c
Acc: NM_001034925.2
ID: 308579
Carnitine palmitoyltransferase 1c (CPT 1C, CPT1-B, CPTI-B) 1.086711
(p = 0.58947)
1.392775↑
(p = 0.007650)
Cpt2
Acc: NM_012930.1
ID: 25413
Carnitine palmitoyltransferase 2 (CPTII) 1.095366
(p = 0.319692)
0.935788
(p = 0.459054)
Acox1
Acc: NM_017340.2
ID: 506811
Acyl-CoA oxidase, palmitoyl (RATACOA1) 0.942485
(p = 0.405327)
1.239981↑
(p = 0.026649)
Acadl
Acc: NM_012819.1
ID: 25287
Acyl-CoA dehydrogenase, long chain (ACOADA, LCAD) 1.038506
(p = 0.607105)
0.897447
(p = 0.286828)
Acadm
Acc: NM_016986.2
ID: 24158
Acyl-CoA dehydrogenase, C-4 to C-12 straight chain (MCAD) 1.018954
(p = 0.786051)
1.120494
(p = 0.185916)
Acads
Acc: NM_022512.1
ID: 64304
Acyl-Coa dehydrogenase, C-2 to C-3 short chain (Scad) 0.947987
(p = 0.686716)
1.163831
(p = 0.106741)
Acadsb
Acc: NM_013084.1
ID: 25618
Acyl-CoA dehydrogenase, short/branched chain 0.767644
(p = 0.056663)
1.578611↑
(p = 0.000470)
Acadvl
Acc: NM_012891.1
ID: 25363
Acyl-CoA dehydrogenase very long chain (VLCAD) 1.023041
(p = 0.81081)
1.104065
(p = 0.242381)
Eci1
Acc: NM_017306.4
ID: 29740
Enoyl-CoA delta isomerase 1(Deci) 1.028304
(p = 0.734099)
1.203436↑
(p = 0.11201)
Echs1
Acc: NM_078623.2
ID: 140547
Enoy-CoA hydratase, short chain 1,
mitochondrial
0.890438
(p = 0.269622)
0.970797
(p = 0.801854)
Ehhadh
Acc: NM_133606.1
ID: 171142
Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase 1.255433↑
(p = 0.004941)
4.521567↑
(p = 1.81E-20)
Eci2
Acc: NM_001006966.1
ID:291075
Enoyl-CoA delta isomerase 2 (Peci) 0.899414
(p = 0.120824)
0.74287↓
(p = 0.000344)
  Fatty Acid Synthesis/ De Novo Lipogenesis   
Gckr
Acc: NM_013120.2
ID: 25658
Glucokinase (hexokinase 4) regulator (GLRE) 1.07709
(p = 0.694603)
2.031414↑
(p = 0.00004)
Gck
Acc: NM_012565.1
ID: 24385
Glukokinase (GLUKA, RNGK2) 0.959106
(p = 0.801909)
1.706245↑
(p = 0.000131)
Pklr
Acc: NM_012624.3
ID: 24651
Pyruvate kinase, liver and RBC (PK1, PKL, Pklg) 1.013481
(p = 0.932088)
1.252908
(p = 0.073772)
Acly
Acc: NM_016987.2
NM_001111095.1
ID: 24159
ATP citrate lyase (ACL, Clatp) 0.998949
(p = 0.98697)
0.737265↓
(p = 0.000026)
Fasn
Acc: NM_01332.1
ID: 50761
Fatty acid synthase 0.706952↓
(p = 0.000244)
0.930935
(p = 0.545657)
Me1
Acc: NM_012600.2
ID: 24552
Malic enzyme 1, NADP(+)-dependent, cytosolic (MOD1) 0.822072
(p = 0.082114)
1.1122701
(p = 0.365453)
Me2
Acc: NM_001111095.1
ID: 307270
Malic enzyme 2, NAD(+)-dependent, mitochondrial
Scd1
Acc: NM_139192.2
ID: 246074
Stearyol-Coenzyme A desaturase 1 1.31285↑
(p = 0.002357)
0.761013
(p = 0.065913)
Elovl1
Acc: NM_001044275.1
ID: 67953.2
ELOVL fatty acid elongase 1 1.011133
(p = 0.897404)
and
0.943484
(p = 0.539378)
0.639064↓
(p = 5.49E-08)
and
0.584865↓
(p = 0.000002)
Elovl2
Acc: NM_001109118.1
ID: 498728
ELOVL fatty acid elongase 2 2.709103
(p = 0.626956)
1.216575
(p = 0.73873)
Elovl4
Acc: NM_001191796.1
XM_001062735.2
ID: 315851
ELOVL fatty acid elongase 4 0.831144
(p = 0.17275)
0.905935
(p = 0.619544)
Elovl5
Acc: NM_134382.1
ID: 171400
ELOVL fatty acid elongase 5 (rELO1) 0.732669↓
(p = 0.000051)
0.768796↓
(p = 0.002744)
Elovl6
Acc: NM_134383.2
ID: 171402
ELOVL fatty acid elongase 6
(Lce2, rELO2)
1.034949
(p = 0.742391)
and
0.974533
(p = 0.82477)
0.993401
(p = 0.969926)
and
1.246617
(p = 0.381630)
Fads1
Acc: NM_053445.2
ID: 84575
Fatty acid desaturase 1 1.241893↑
(p = 0.044164)
0.760080↓
(p = 0.006978)
Fads2
Acc: NM_031344.2
ID: 83512
Fatty acid desaturase 2 (Fadsd6) 2.161421↑
(p = 8.64E-12)
0.699797↓
(p = 0.000734)
Mlcyd
Acc: NM_053477.1
ID: 85239
Malonyl-CoA decarboxylase 1.050798
(p = 0.506797)
0.988309
(p = 0.909295)
  Triglyceride (TG) Synthesis/VLDL-TG Assembly   
Agpat1
Acc: NM_212458.1
ID: 406165
1-Acylglycerol-3-phosphate O-acyltransferase 1 0.992486
(p = 0.954388)
1.306654↑
(p = 0.038298)
Agpat2
Acc: NM_001107821.1
ID: 311821
1-Acylglycerol-3-phosphate O-acyltransferase 2 1.090764
(p = 0.284579)
0.732075↓
(p = 0.001118)
Agpat3
Acc: NM_001106378.1
ID: 311821
1-Acylglycerol-3-phosphate O-acyltransferase 3 0.943450
(p = 0.5559170)
0.954861
(p = 0.819498)
Agpat6
Acc: NM_001047849.1
ID: 305166
1-Acylglycerol-3-phosphate O-acyltransferase 6 (RGD1310520) 0.976834
(p = 0.754188)
1.114009
(p = 0.256854)
Agpat9
Acc: 001025670.1
ID: 305166
1-Acylglycerol-3-phosphate O-acyltransferase 9 0.753988↓
(p = 0.002922)
0.791921
(p = 0.185478)
Mogat1
Acc: NM_001108803.1
ID: 363261
Monoacylglycerol O-acyltransferase
1
0.875509
(p = 0.391965)
0.592216↓
(p = 0.000892)
Dgat1
Acc: NM_053437.1
ID: 84497
Diacylglycerol O-acyltransferase 1 (ARAT, Dgat) 0.928218
(p = 0.359588)
1.485906↑
(p = 0.000110)
Dgat2
Acc: NM_001012345.1
ID: 252900
Diacylglycerol O-acyltransferase 2 (ARAT) 0.911253
(p = 0.262778)
1.451837↑
(p = 0.000067)
Arf3
Acc: NM_080904.2
ID: 140940
ADP-ribosylation factor 3 (AC1-253) 1.119282
(p = 0.211709)
0.530910↓
(p = 8.33E-12)
  Cholesterol Synthesis/Metabolism   
Acat2
Acc: NM_001006995.1
ID: 308100
Acetyl-CoA acetyltransferase 2 (Acat3, Ab2-076) 0.952536
(p = 0.440569)
0.989649
(p = 0.940796)
Hmgcr
Acc: NM_013134.2
ID: 25675
3-Hydroxy-3-methylglutaryl-CoA reductase (3H3M) 1.070248
(p = 0.412922)
0.663322↓
(p = 0.008738)
Insig 1
Acc: NM_022392.1
ID: 64194
Insulin induced gene 1 1.242984↑
(p = 0.031151)
1.549161↑
(p = 0.003666)
Insig 2
Acc: NM_178091.4
ID: 288985
Insulin induced gene 2 0.864261
(p = 0.073905)
1.265492
(p = 0.070329)
Ldlr
Acc: NM_175762.2
ID: 300438
Low density lipoprotein receptor
(LDLRA)
0.994617
(p = 0.974217)
0.996123
(p = 0.972744)
Mvk
Acc: NM_031063.1
ID: 81727
Mevalonate kinase (Lrbp) 1.014383
(p = 0.892250)
1.129775
(p = 0.245258)
Npc1
Acc:
NM_001002025.11
ID: 266732
Niemann-Pick disease, type C1
(Cdig2)
1.002647
(p = 998400)
0.806589
(p = 0.314930)
  Proteins Involved in Lipid Clearance   
Abca4
Acc: NM_00110772.1
ID: 310836
ATP-binding cassette, subfamily A (ABC1), member 4 (ABCR)
Abcb4
Acc: NM_012690.1
ID: 24891
ATP-binding cassette, subfamily B (MDR/TAP), member 4 (Mdr2, Pgy3) 1.001665
(p = 0.990316)
1.352659↑
(p = 0.002415)
Abcb11
Acc: NM_031760.1
ID: 83569
ATP-binding cassette, subfamily B (MDR/TAP), member 11 (Bsep, Spgp) 0.976717
(p = 0.887315)
2.314507↑
(p = 0.000044)
Abcc3
Acc: NM_080581.1
ID: 140668
ATP-binding cassette, subfamily C (CFTR/MRP), member 3 (Mlp2, Mrp3) 1.13094
(p = 0.112959)
0.554283↓
(p = 3.47E-08)
Abcc6
Acc: NM_031013.1
ID: 81642
ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Mrp6) 1.016698
(p = 0.931493)
2.173900↑
(p = 0.000012)
Abcd1
Acc: NM_001108821.1
ID: 363516
ATP-binding cassette, subfamily D (ALD), member 3 (RGD1562128) 0.966064
(p = 0.685132)
1.009964
(p = 0.42331)
Abcd3
Acc: NM_012804.1
ID: 25270
ATP-binging cassette, subfamily D (ALD), member 3 (PMP70, Pxmp1) 1.071230
(p = 0.315252)
1.178834
(p = 0.074443)
Abcg2
Acc: NM_181381.2
ID: 312382
ATP-binding cassette, subfamily G (WHITE), member 2 (BCRP1) 0.940064
(p = 0.737683)
Abcg5
Acc: NM_053754.2
ID: 114628
ATP-binding cassette, subfamily G (WHITE), member 5 0.980266
(p = 0.916333)
0.810473
(p = 506217)
Apoa4
Acc: NM_012737.1
ID: 25080
Apolipoprotein A-IV (Apo-AIV, ApoA-IV, ApoAIV) 0.886124
(p = 637386)
1.397129
(p = 0.121159)
Apob
Acc: NM_019287.2
ID: 54225
Apolipoprotein B (Aa1064, AC1-060, Apo B-100, ApoB-100, ApoB-48) 0.726099
(p = 0.275237)
5.457586↑
(p = 5.48E-13)
Apoc2
Acc: NM_001085352.1
ID: 292697
Apolipoprotein C-II (RGD1560725) 0.935620
(p = 0.636398)
3.570020↑
(p = 2.22E-17)
Apoc3
Acc: NM_012501.1
ID: 24207
Apolipoprotein C-III (ApoC-III, apo-CIII) 0.912894
(p = 0.302897)
8.022169↑
(p = 6.3E-25)
Apoe
Acc: NM_138828.2
ID: 25728
Apolipoprotein E (APOEA) 1.177138
(p = 0.066475)
0.419997↓
(p = 1.01E-13)
Apof
Acc: NM_001024351.1
ID: 500761
Apolipoprotein F
Lpl
Acc: NM_012498.2
ID: 24539
Lipoprotein lipase 0.985218
(p = 0.852647)
0.543580↓
(p = 4.93E-12)
Vldlr
Acc: NM_013155.2
ID: 25696
Very low density lipoprotein receptor 1.062438
(p = 0.461893)
Or
0.888362
(p = 0.228697)
1.091786
(p = 0.205328)
Or
1.200139↑
(p = 0.030468)
Ppt1
Acc: NM_022502.2
ID: 29411
Palmitoyl-protein thioesterase 1 (Ppt) 0.959614
(p = 0.555592)
0.505612↓
(p = 5.61E-15)
(p = 0.192733)
  Central Metabolic Regulators (Lipid Transcription Factors)   
Foxa1
Acc: NM_012742.1
ID: 25098
Forkhead box A1 0.861648
(p = 0.59303)
0.790538
(p = 0.286379)
Hnf4a
Acc: NM_022180.1
ID: 25735
Hepatocyte nuclear factor 4, alpha (Hnf4alpha, Hnf4a) 0.969862
(p = 0.899345)
0.897382
(p = 0.784789)
Mlxipl
Acc: NM_133552.1
ID: 171078
MLX interacting protein-like (ChREBP, WS-bHLH, Wbscr14, bHLHd14) 0.644817↓
(p = 1.16E-08)
0.923704
(p = 0.439391)
Nr1h3
Acc: NM_031627.2
ID: 58852
Nuclear receptor subfamily 1, group H, member 3 (LXRalpha) 1.002888
(p = 0.964985)
1.708129↑
(p = 0.000001)
Ppara
Acc: NM_013196.1
ID: 25747
Peroxisome proliferator activated receptor alpha (PPAR) 0.897809
(p = 0.394852)
2.537218↑
(p = 0.000000)
Ppard
Acc: NM_013141.2
ID: 25682
Peroxisome proliferator activated receptor delta (Pparb) 1.000165
(p = 0.998956)
and
0.991657
(p = 0.964720)
1.428902↑
(p = 0.005855)
and
1.167184
(p = 0.271325)
Pparg
Acc: NM_013124.3 NM_001145366.1
NM_001145367.1
ID: 25664
Peroxisome proliferator activated receptor gamma 0.801471↓
(p = 0.003078)
0.924624
(p = 0.447736)
Ppargc1a
Acc: NM_031347.1
ID: 83516
Peroxisome proliferator activated receptor gamma, coactivator 1 alpha (Ppargc1) 0.719326
(p = 0.192474)
1.479666
(p = 0.067544)
Ppargc1b
Acc: NM_176075.2
ID: 291567
Peroxisome proliferator activated receptor, coactivator 1 beta (PGC1beta, Perc) 1.020089
(p = 0.82730)
0.633941↓
(p = 0.001608)
Srebf1
Acc: XM_213329.5
XM_001075680.2
ID: 78968
Sterol regulatory element binding transcription factor 1 (ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1) 0.986205
(p = 0.859100)
and
1.018349
(p = 0.853102)
1.837534↑
(p = 9.10E-08)
and
1.865578↑
(p = 0.000003)
Srebf2
Acc: NM_001033694.1
ID: 300095
Sterol regulatory element binding transcription factor 2 (SREBP-2, SREBP2-retired, Srebf2) 1.028776
(p = 0.707159)
0.82597
(p = 0.471771)
Xbp1
Acc: NM_001004210.1
ID: 289754
X-box binding protein 1 (HTF) 1.055655
(p = 0.434625)
1.317409↑
(p = 0.000651)