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Table 3 Adipose tissue genes responsive to feeding of a high-fructose diet (HFrD) or HFrD supplemented with NDGA (HFrD-NDGA)

From: Microarray analysis of gene expression in liver, adipose tissue and skeletal muscle in response to chronic dietary administration of NDGA to high-fructose fed dyslipidemic rats

Gene symbol/GenBank accession/Gene ID Entrez gene name HFrD/Chow
(Fold-change)
HFrD-NDGA/HFrD
(Fold-change)
  Fatty Acid Transport   
Slc27a1
Acc: NM_053580.2
ID: 94172
Soluble carrier family 27 (fatty acid transporter), member 1 (FATP1) 0.626371↓
(p = 0.000005)
1.243585↑
(p = 0.035818)
Slc27a2
Acc: NM_031736.1
ID: 65192
Soluble carrier family 27 (fatty acid transporter), member 2 (FATP2) 0.843521
(p = 0.704995)
  Acyl-CoA Synthetases   
Acsl1
Acc: NM_012820.1
ID: 25288
Acyl-CoA synthetase long-chain family member 1 (ACS, Acas, COAA, Facl2) 0.871766
(p = 0.143945)
1.022277
(p = 0.780026)
Acsl4
Acc: NM_053623.1
ID: 113976
Acyl-CoA synthetase long-chain family member 4 (ACS4, Facl4) 0.878305
(p = 0.54153)
0.964436
(p = 0.62090)
Acsm3
Acc: NM_033231.1
ID: 24763
Acyl-CoA synthetase medium-chain family member 3 (Sa, Sah) 0.987186
(p = 0.961215)
0.805024
(p = 0.413656)
Acss2
Acc: NM_001107793.1
ID: 311569
Acyl-CoA synthetase short chain family member 2 (Acss2) 0.966705
(p = 0.717211)
0.884133
(p = 0.161879)
  Fatty Acid Oxidation   
Cpt1a
Acc: NM_031559.2
ID: 25757
Carnitine palmitoyltransferase 1a,
liver (CPT-1a)
0.929886
(p = 0.346192)
0.971389
(p = 0.737175)
Cpt1b
Acc: NM_013200.1
ID: 25756
Carnitine palmitoyltransferase 1b,
muscle (CPT-1B, M-CPT1)
0.705154↓
(p = 0.000182)
1.080327
(p = 0.411449)
Cpt1c
Acc: NM_001034925.2
ID: 308579
Carnitine palmitoyltransferase 1c (CPT 1C, CPT1-B, CPTI-B) 0.912484
(p = 0.292825)
1.076052
(p = 0.61451)
Cpt2
Acc: NM_012930.1
ID: 25413
Carnitine palmitoyltransferase 2
(CPTII)
1.058655
(p = 0.394189)
1.03461
(p = 0.630057)
Acox1
Acc: NM_017340.2
ID: 506811
Acyl-CoA oxidase, palmitoyl (RATACOA1) 1.291301↑
(p = 0.000954)
1.086216
(p = 0.293942)
Acadl
Acc: NM_012819.1
ID: 25287
Acyl-CoA dehydrogenase, long chain (ACOADA, LCAD) 1.024278
(p = 0.778232)
0.976708
(p = 0.800795)
Acadm
Acc: NM_016986.2
ID: 24158
Acyl-CoA dehydrogenase, C-4 to C-12 straight chain (MCAD) 1.017514
(p = 0.84005)
0.917314
(p = 0.340538)
Acads
Acc: NM_022512.1
ID: 64304
Acyl-Coa dehydrogenase, C-2 to C-3 short chain (Scad) 0.645793↓
(p = 0.000149)
1.280965
(p = 0.065028)
Acadsb
Acc: NM_013084.1
ID: 25618
Acyl-CoA dehydrogenase, short/branched chain 0.775064
(p = 0.065038)
1.804414↑
(p = 0.00009)
Acadvl
Acc: NM_012891.1
ID: 25363
Acyl-CoA dehydrogenase very long chain (VLCAD) 0.785093↓
(p = 0.006311)
1.285064↑
(p = 0.003725)
Eci1
Acc: NM_017306.4
ID: 29740
Enoyl-CoA delta isomerase 1(Deci) 0.978982
(p = 0.785245)
1.134394
(p = 0.11201)
Echs1
Acc: NM_078623.2
ID: 140547
Enoy-CoA hydratase, short chain 1,
mitochondrial
0.764837↓
(p = 0.007566)
1.220593
(p = 0.080591)
Ehhadh
Acc: NM_133606.1
ID: 171142
Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase 0.64736↓
(p = 0.000141)
1.219944
(p = 0.061876)
Eci2
Acc: NM_001006966.1
ID:291075
Enoyl-CoA delta isomerase 2 (Peci) 0.899414
(p = 0.120824)
0.74287↓
(p = 0.000344)
  Fatty Acid Synthesis/ De Novo   
  Lipogenesis   
Gckr
Acc: NM_013120.2
ID: 25658
Glucokinase (hexokinase 4) regulator (GLRE) 0.755501
(p = 0.055196)
1.126918
(p = 0.490323)
Gck
Acc: NM_012565.1
ID: 24385
Glukokinase (GLUKA, RNGK2) 4.265985↑
(p = 6.89E-18)
0.302628↓
(p = 4.47E-11)
Pklr
Acc: NM_012624.3
ID: 24651
Pyruvate kinase, liver and RBC (PK1, PKL, Pklg) 2.097495↑
(p = 0.000451)
0.498737↓
(p = 0.000675)
Acly
Acc: NM_016987.2
NM_001111095.1
ID: 24159
ATP citrate lyase (ACL, Clatp) 1.295435↑
(p = 0.000403)
0.895746
(p = 0.143597)
Fasn
Acc: NM_01332.1
ID: 50761
Fatty acid synthase 1.08142
(p = 0.423101)
0.904824
(p = 0.357733)
Me1
Acc: NM_012600.2
ID: 24552
Malic enzyme 1, NADP(+)-dependent, cytosolic (MOD1) 0.847973
(p = 0.065373)
0.990152
(p = 0.920281)
Me2
Acc: NM_001111095.1
ID: 307270
Malic enzyme 2, NAD(+)-dependent, mitochondrial
Scd1
Acc: NM_139192.2
ID: 246074
Stearyol-Coenzyme A desaturase 1 9.92997↑
(p = 0.00E + 00)
0.367553↓
(p = 3.10E-28)
Elovl1
Acc: NM_001044275.1
ID: 67953.2
ELOVL fatty acid elongase 1 0.696973↓
(p = 0.)
and
1.025883
(p = 0.77018)
1.502326↑
(p = 5.63E-09)
and
1.199776
(p = 0.056696)
Elovl2
Acc: NM_001109118.1
ID: 498728
ELOVL fatty acid elongase 2 0.712072
(p = 0.389679)
0.330644
(p = 0.176175)
Elovl4
Acc: NM_001191796.1
XM_001062735.2
ID: 315851
ELOVL fatty acid elongase 4 1.053677
(p = 0.719414)
0.950803
(p = 0.678269)
Elovl5
Acc: NM_134382.1
ID: 171400
ELOVL fatty acid elongase 5 (rELO1) 1.027579
(p = 0.719414)
2.101966↑
(p = 1.14E-17)
Elovl6
Acc: NM_134383.2
ID: 171402
ELOVL fatty acid elongase 6 (Lce2, rELO2) 0.511033↓
(p = 2.11E-11)
and
1.322709↑
(p = 0.037357)
1.436011↑
(p = 0.001273)
and
0.797587
(p = 0.0795)
Fads1
Acc: NM_053445.2
ID: 84575
Fatty acid desaturase 1 1.16415
(p = 0.102452)
0.828712↓
(p = 0.042428)
Fads2
Acc: NM_031344.2
ID: 83512
Fatty acid desaturase 2 (Fadsd6) 1.036468
(p = 0.84278)
0.890867
(p = 0.485008)
Mlcyd
Acc: NM_053477.1
ID: 85239
Malonyl-CoA decarboxylase 1.06015
(p = 0.581558)
0.800024↓
(p = 0.047506)
  Triglyceride (TG) Synthesis/VLDL-TG Assembly   
Agpat1
Acc: NM_212458.1
ID: 406165
1-Acylglycerol-3-phosphate O-acyltransferase 1 1.733174↑
(p = 0.000011)
0.551598↓
(p = 0.000015)
Agpat2
Acc: NM_001107821.1
ID: 311821
1-Acylglycerol-3-phosphate O-acyltransferase 2 0.890825
(p = 0.154834)
0.98959
(p = 0.895733)
Agpat3
Acc: NM_001106378.1
ID: 311821
1-Acylglycerol-3-phosphate O-acyltransferase 3 0.625706↓
(p = 0.004796)
1.138055
(p = 0.352178)
Agpat6
Acc: NM_001047849.1
ID: 305166
1-Acylglycerol-3-phosphate O-acyltransferase 6 (RGD1310520) 0.668305↓
(p = 0.754188)
1.483745↑
(p = 0.000001)
Agpat9
Acc: 001025670.1
ID: 305166
1-Acylglycerol-3-phosphate O-acyltransferase 9 0.702126↓
(p = 0.007365)
1.461539↑
(p = 0.002906)
Mogat1
Acc: NM_001108803.1
ID: 363261
Monoacylglycerol O-acyltransferase 1 0.911577
(p = 0.405954)
0.977825
(p = 0.860977)
Dgat1
Acc: NM_053437.1
ID: 84497
Diacylglycerol O-acyltransferase 1 (ARAT, Dgat) 0.766526↓
(p = 0.033377)
1.35964↑
(p = 0.012554)
Dgat2
Acc: NM_001012345.1
ID: 252900
Diacylglycerol O-acyltransferase 2 (ARAT) 1.000764
(p = 0.992838)
0.890682
(p = 0.159626)
Arf3
Acc: NM_080904.2
ID: 140940
ADP-ribosylation factor 3 (AC1-253) 1.253088↑
(p = 0.000991)
0.745999↓
(p = 0.000289)
  Cholesterol Synthesis/Metabolism   
Acat2
Acc: NM_001006995.1
ID: 308100
Acetyl-CoA acetyltransferase 2 (Acat3, Ab2-076) 1.149942
(p = 0.064026)
0.846982↓
(p = 0.020354)
Hmgcr Acc: NM_013134.2 ID: 25675 3-Hydroxy-3-methylglutaryl-CoA reductase (3H3M) 0.614003↓ (p = 0.000734) 1.212062 (p = 0.155741)
Insig 1
Acc: NM_022392.1
ID: 64194
Insulin induced gene 1 1.046145
(p = 0.573908)
0.618888↓
(p = 0.000006)
Insig 2
Acc: NM_178091.4
ID: 288985
Insulin induced gene 2 0.823541
(p = 0.133816)
1.467193↑
(p = 0.003866)
Ldlr
Acc: NM_175762.2
ID: 300438
Low density lipoprotein receptor (LDLRA) 0.761982
(p = 0.148211)
1.204468
(p = 0.362466)
Mvk
Acc: NM_031063.1
ID: 81727
Mevalonate kinase (Lrbp) 1.024571
(p = 0.839357)
1.168772
(p = 0.150024)
Npc1
Acc: NM_001002025.11
ID: 266732
Niemann-Pick disease, type C1 (Cdig2) 0.838672
(p = 0.861612)
1.21535
(p = 0.847542)
  Proteins Involved in Lipid Clearance   
Abca4
Acc: NM_00110772.1
ID: 310836
ATP-binding cassette, subfamily A (ABC1), member 4 (ABCR)
Abcb4
Acc: NM_012690.1
ID: 24891
ATP-binding cassette, subfamily B (MDR/TAP), member 4 (Mdr2, Pgy3) 1.290231
(p = 0.284859)
0.894225
(p = 0.438512)
Abcb11
Acc: NM_031760.1
ID: 83569
ATP-binding cassette, subfamily B (MDR/TAP), member 11 (Bsep, Spgp) 0.693218
(p = 0.05412)
1.397109
(p = 0.086006)
Abcc3
Acc: NM_080581.1
ID: 140668
ATP-binding cassette, subfamily C (CFTR/MRP), member 3 (Mlp2, Mrp3) 0.930144
(p = 0.499966)
0.930223
(p = 0.509623)
Abcc6
Acc: NM_031013.1
ID: 81642
ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Mrp6) 1.044104
(p = 0.931493)
0.953551
(p = 0.836794)
Abcd1
Acc: NM_001108821.1
ID: 363516
ATP-binding cassette, subfamily D (ALD), member 3 (RGD1562128) 0.981591
(p = 0.867544)
0.973671
(p = 0.807543)
Abcd3
Acc: NM_012804.1
ID: 25270
ATP-binging cassette, subfamily D (ALD), member 3 (PMP70, Pxmp1) 0.775986↓
(p = 0.000407)
1.067058
(p = 0.3708)
Abcg2
Acc: NM_181381.2
ID: 312382
ATP-binding cassette, subfamily G (WHITE), member 2 (BCRP1) 0.840673
(p = 0.694657)
1.966469
(p = 0.051575)
Abcg5
Acc: NM_053754.2
ID: 114628
ATP-binding cassette, subfamily G (WHITE), member 5 1.289574
(p = 0.31897)
0.839246
(p = 0.375668)
Apoa4
Acc: NM_012737.1
ID: 25080
Apolipoprotein A-IV (Apo-AIV, ApoA-IV, ApoAIV) 1.975251↑
(p = 0.005407)
0.701419
(p = 0.119689)
Apob
Acc: NM_019287.2
ID: 54225
Apolipoprotein B (Aa1064, AC1-060, Apo B-100, ApoB-100, ApoB-48) 0.90111
(p = 0.750761)
1.187596
(p = 0.618021)
Apoc2
Acc: NM_001085352.1
ID: 292697
Apolipoprotein C-II (RGD1560725) 2.057009↑
(p = 0.000592)
0.532413↓
(p = 0.000001)
Apoc3
Acc: NM_012501.1
ID: 24207
Apolipoprotein C-III (ApoC-III, apo-CIII) 0.684698↓
(p = 0.000263)
1.307856↑
(p = 0.008469)
Apoe
Acc: NM_138828.2
ID: 25728
Apolipoprotein E (APOEA) 1.485673↑
(p = 0.000003)
0.778654↓
(p = 0.004399)
Apof
Acc: NM_001024351.1
ID: 500761
Apolipoprotein F
Lpl
Acc: NM_012498.2
ID: 24539
Lipoprotein lipase 1.135422
(p = 0.100839)
0.812916↓
(p = 0.007915)
Vldlr
Acc: NM_013155.2
ID: 25696
Very low density lipoprotein receptor 0.6722↓
(p = 0.000001)
Or
0.486999↓
(p = 8.10E-08)
1.096751
(p = 0.283284)
Or
1.520316↑
(p = 0.002103)
Ppt1
Acc: NM_022502.2
ID: 29411
Palmitoyl-protein thioesterase 1 (Ppt) 0.9252
(p = 0.307699)
1.076592
(p = 0.320819)
(p = 0.192733)
  Central Metabolic Regulators (Lipid Transcription Factors)   
Foxa1
Acc: NM_012742.1
ID: 25098
Forkhead box A1 0.828962
(p = 0.418498)
1.067287
(p = 0.72547)
Hnf4a
Acc: NM_022180.1
ID: 25735
Hepatocyte nuclear factor 4, alpha (Hnf4alpha, Hnf4a) 1.208695
(p = 0.660749)
0.934321
(p = 0.806661)
Mlxipl
Acc: NM_133552.1
ID: 171078
MLX interacting protein-like (ChREBP, WS-bHLH, Wbscr14, bHLHd14) 1.019326
(p = 0.831873)
1.23554↑
(p = 0.015243)
Nr1h3
Acc: NM_031627.2
ID: 58852
Nuclear receptor subfamily 1, group H, member 3 (LXRalpha) 0.898224
(p = 0.132662)
1.22274↑
(p = 0.00316)
Ppara
Acc: NM_013196.1
ID: 25747
Peroxisome proliferator activated receptor alpha (PPAR) 1.042152
(p = 0.702728)
1.34318↑
(p = 0.01657)
Ppard
Acc: NM_013141.2
ID: 25682
Peroxisome proliferator activated receptor delta (Pparb) 1.049635
(p = 0.640966)
and
1.023475
(p = 0.858495)
1.001442
(p = 0.988966)
and
0.929482
(p = 0.61664)
Pparg
Acc: NM_013124.3
NM_001145366.1
NM_001145367.1
ID: 25664
Peroxisome proliferator activated receptor gamma 1.140175
(p = 0.07102)
0.96347
(p = 0.648174)
Ppargc1a
Acc: NM_031347.1
ID: 83516
Peroxisome proliferator activated receptor gamma, coactivator 1 alpha (Ppargc1) 2.166136↑
(p = 0.013221)
0.49897
(p = 0.089406)
Ppargc1b
Acc: NM_176075.2
ID: 291567
Peroxisome proliferator activated receptor, coactivator 1 beta (PGC1beta, Perc) 0.787663↓
(p = 0.007863)
1.092996
(p = 0.296335)
Srebf1
Acc: XM_213329.5
XM_001075680.2
ID: 78968
Sterol regulatory element binding transcription factor 1 (ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1) 0.810661↓
(p = 0.012341)
and
0.885992
(p = 0.449261)
1.17608
(p = 0.063087)
and
1.460992↑
(p = 0.011985)
Srebf2
Acc: NM_001033694.1
ID: 300095
Sterol regulatory element binding transcription factor 2 (SREBP-2, SREBP2-retired, Srebf2) 0.854579
(p = 0.062966)
0.964258
(p = 0.651328)
Xbp1
Acc: NM_001004210.1
ID: 289754
X-box binding protein 1 (HTF) 1.168979
(p = 0.087563)
1.080755
(p = 0.380509)