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Table 3 Adipose tissue genes responsive to feeding of a high-fructose diet (HFrD) or HFrD supplemented with NDGA (HFrD-NDGA)

From: Microarray analysis of gene expression in liver, adipose tissue and skeletal muscle in response to chronic dietary administration of NDGA to high-fructose fed dyslipidemic rats

Gene symbol/GenBank accession/Gene ID Entrez gene name HFrD/Chow (Fold-change) HFrD-NDGA/HFrD (Fold-change)
  Fatty Acid Transport   
Slc27a1 Acc: NM_053580.2 ID: 94172 Soluble carrier family 27 (fatty acid transporter), member 1 (FATP1) 0.626371↓ (p = 0.000005) 1.243585↑ (p = 0.035818)
Slc27a2 Acc: NM_031736.1 ID: 65192 Soluble carrier family 27 (fatty acid transporter), member 2 (FATP2) 0.843521 (p = 0.704995)
  Acyl-CoA Synthetases   
Acsl1 Acc: NM_012820.1 ID: 25288 Acyl-CoA synthetase long-chain family member 1 (ACS, Acas, COAA, Facl2) 0.871766 (p = 0.143945) 1.022277 (p = 0.780026)
Acsl4 Acc: NM_053623.1 ID: 113976 Acyl-CoA synthetase long-chain family member 4 (ACS4, Facl4) 0.878305 (p = 0.54153) 0.964436 (p = 0.62090)
Acsm3 Acc: NM_033231.1 ID: 24763 Acyl-CoA synthetase medium-chain family member 3 (Sa, Sah) 0.987186 (p = 0.961215) 0.805024 (p = 0.413656)
Acss2 Acc: NM_001107793.1 ID: 311569 Acyl-CoA synthetase short chain family member 2 (Acss2) 0.966705 (p = 0.717211) 0.884133 (p = 0.161879)
  Fatty Acid Oxidation   
Cpt1a Acc: NM_031559.2 ID: 25757 Carnitine palmitoyltransferase 1a, liver (CPT-1a) 0.929886 (p = 0.346192) 0.971389 (p = 0.737175)
Cpt1b Acc: NM_013200.1 ID: 25756 Carnitine palmitoyltransferase 1b, muscle (CPT-1B, M-CPT1) 0.705154↓ (p = 0.000182) 1.080327 (p = 0.411449)
Cpt1c Acc: NM_001034925.2 ID: 308579 Carnitine palmitoyltransferase 1c (CPT 1C, CPT1-B, CPTI-B) 0.912484 (p = 0.292825) 1.076052 (p = 0.61451)
Cpt2 Acc: NM_012930.1 ID: 25413 Carnitine palmitoyltransferase 2 (CPTII) 1.058655 (p = 0.394189) 1.03461 (p = 0.630057)
Acox1 Acc: NM_017340.2 ID: 506811 Acyl-CoA oxidase, palmitoyl (RATACOA1) 1.291301↑ (p = 0.000954) 1.086216 (p = 0.293942)
Acadl Acc: NM_012819.1 ID: 25287 Acyl-CoA dehydrogenase, long chain (ACOADA, LCAD) 1.024278 (p = 0.778232) 0.976708 (p = 0.800795)
Acadm Acc: NM_016986.2 ID: 24158 Acyl-CoA dehydrogenase, C-4 to C-12 straight chain (MCAD) 1.017514 (p = 0.84005) 0.917314 (p = 0.340538)
Acads Acc: NM_022512.1 ID: 64304 Acyl-Coa dehydrogenase, C-2 to C-3 short chain (Scad) 0.645793↓ (p = 0.000149) 1.280965 (p = 0.065028)
Acadsb Acc: NM_013084.1 ID: 25618 Acyl-CoA dehydrogenase, short/branched chain 0.775064 (p = 0.065038) 1.804414↑ (p = 0.00009)
Acadvl Acc: NM_012891.1 ID: 25363 Acyl-CoA dehydrogenase very long chain (VLCAD) 0.785093↓ (p = 0.006311) 1.285064↑ (p = 0.003725)
Eci1 Acc: NM_017306.4 ID: 29740 Enoyl-CoA delta isomerase 1(Deci) 0.978982 (p = 0.785245) 1.134394 (p = 0.11201)
Echs1 Acc: NM_078623.2 ID: 140547 Enoy-CoA hydratase, short chain 1, mitochondrial 0.764837↓ (p = 0.007566) 1.220593 (p = 0.080591)
Ehhadh Acc: NM_133606.1 ID: 171142 Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase 0.64736↓ (p = 0.000141) 1.219944 (p = 0.061876)
Eci2 Acc: NM_001006966.1 ID:291075 Enoyl-CoA delta isomerase 2 (Peci) 0.899414 (p = 0.120824) 0.74287↓ (p = 0.000344)
  Fatty Acid Synthesis/ De Novo   
  Lipogenesis   
Gckr Acc: NM_013120.2 ID: 25658 Glucokinase (hexokinase 4) regulator (GLRE) 0.755501 (p = 0.055196) 1.126918 (p = 0.490323)
Gck Acc: NM_012565.1 ID: 24385 Glukokinase (GLUKA, RNGK2) 4.265985↑ (p = 6.89E-18) 0.302628↓ (p = 4.47E-11)
Pklr Acc: NM_012624.3 ID: 24651 Pyruvate kinase, liver and RBC (PK1, PKL, Pklg) 2.097495↑ (p = 0.000451) 0.498737↓ (p = 0.000675)
Acly Acc: NM_016987.2 NM_001111095.1 ID: 24159 ATP citrate lyase (ACL, Clatp) 1.295435↑ (p = 0.000403) 0.895746 (p = 0.143597)
Fasn Acc: NM_01332.1 ID: 50761 Fatty acid synthase 1.08142 (p = 0.423101) 0.904824 (p = 0.357733)
Me1 Acc: NM_012600.2 ID: 24552 Malic enzyme 1, NADP(+)-dependent, cytosolic (MOD1) 0.847973 (p = 0.065373) 0.990152 (p = 0.920281)
Me2 Acc: NM_001111095.1 ID: 307270 Malic enzyme 2, NAD(+)-dependent, mitochondrial
Scd1 Acc: NM_139192.2 ID: 246074 Stearyol-Coenzyme A desaturase 1 9.92997↑ (p = 0.00E + 00) 0.367553↓ (p = 3.10E-28)
Elovl1 Acc: NM_001044275.1 ID: 67953.2 ELOVL fatty acid elongase 1 0.696973↓ (p = 0.) and 1.025883 (p = 0.77018) 1.502326↑ (p = 5.63E-09) and 1.199776 (p = 0.056696)
Elovl2 Acc: NM_001109118.1 ID: 498728 ELOVL fatty acid elongase 2 0.712072 (p = 0.389679) 0.330644 (p = 0.176175)
Elovl4 Acc: NM_001191796.1 XM_001062735.2 ID: 315851 ELOVL fatty acid elongase 4 1.053677 (p = 0.719414) 0.950803 (p = 0.678269)
Elovl5 Acc: NM_134382.1 ID: 171400 ELOVL fatty acid elongase 5 (rELO1) 1.027579 (p = 0.719414) 2.101966↑ (p = 1.14E-17)
Elovl6 Acc: NM_134383.2 ID: 171402 ELOVL fatty acid elongase 6 (Lce2, rELO2) 0.511033↓ (p = 2.11E-11) and 1.322709↑ (p = 0.037357) 1.436011↑ (p = 0.001273) and 0.797587 (p = 0.0795)
Fads1 Acc: NM_053445.2 ID: 84575 Fatty acid desaturase 1 1.16415 (p = 0.102452) 0.828712↓ (p = 0.042428)
Fads2 Acc: NM_031344.2 ID: 83512 Fatty acid desaturase 2 (Fadsd6) 1.036468 (p = 0.84278) 0.890867 (p = 0.485008)
Mlcyd Acc: NM_053477.1 ID: 85239 Malonyl-CoA decarboxylase 1.06015 (p = 0.581558) 0.800024↓ (p = 0.047506)
  Triglyceride (TG) Synthesis/VLDL-TG Assembly   
Agpat1 Acc: NM_212458.1 ID: 406165 1-Acylglycerol-3-phosphate O-acyltransferase 1 1.733174↑ (p = 0.000011) 0.551598↓ (p = 0.000015)
Agpat2 Acc: NM_001107821.1 ID: 311821 1-Acylglycerol-3-phosphate O-acyltransferase 2 0.890825 (p = 0.154834) 0.98959 (p = 0.895733)
Agpat3 Acc: NM_001106378.1 ID: 311821 1-Acylglycerol-3-phosphate O-acyltransferase 3 0.625706↓ (p = 0.004796) 1.138055 (p = 0.352178)
Agpat6 Acc: NM_001047849.1 ID: 305166 1-Acylglycerol-3-phosphate O-acyltransferase 6 (RGD1310520) 0.668305↓ (p = 0.754188) 1.483745↑ (p = 0.000001)
Agpat9 Acc: 001025670.1 ID: 305166 1-Acylglycerol-3-phosphate O-acyltransferase 9 0.702126↓ (p = 0.007365) 1.461539↑ (p = 0.002906)
Mogat1 Acc: NM_001108803.1 ID: 363261 Monoacylglycerol O-acyltransferase 1 0.911577 (p = 0.405954) 0.977825 (p = 0.860977)
Dgat1 Acc: NM_053437.1 ID: 84497 Diacylglycerol O-acyltransferase 1 (ARAT, Dgat) 0.766526↓ (p = 0.033377) 1.35964↑ (p = 0.012554)
Dgat2 Acc: NM_001012345.1 ID: 252900 Diacylglycerol O-acyltransferase 2 (ARAT) 1.000764 (p = 0.992838) 0.890682 (p = 0.159626)
Arf3 Acc: NM_080904.2 ID: 140940 ADP-ribosylation factor 3 (AC1-253) 1.253088↑ (p = 0.000991) 0.745999↓ (p = 0.000289)
  Cholesterol Synthesis/Metabolism   
Acat2 Acc: NM_001006995.1 ID: 308100 Acetyl-CoA acetyltransferase 2 (Acat3, Ab2-076) 1.149942 (p = 0.064026) 0.846982↓ (p = 0.020354)
Hmgcr Acc: NM_013134.2 ID: 25675 3-Hydroxy-3-methylglutaryl-CoA reductase (3H3M) 0.614003↓ (p = 0.000734) 1.212062 (p = 0.155741)
Insig 1 Acc: NM_022392.1 ID: 64194 Insulin induced gene 1 1.046145 (p = 0.573908) 0.618888↓ (p = 0.000006)
Insig 2 Acc: NM_178091.4 ID: 288985 Insulin induced gene 2 0.823541 (p = 0.133816) 1.467193↑ (p = 0.003866)
Ldlr Acc: NM_175762.2 ID: 300438 Low density lipoprotein receptor (LDLRA) 0.761982 (p = 0.148211) 1.204468 (p = 0.362466)
Mvk Acc: NM_031063.1 ID: 81727 Mevalonate kinase (Lrbp) 1.024571 (p = 0.839357) 1.168772 (p = 0.150024)
Npc1 Acc: NM_001002025.11 ID: 266732 Niemann-Pick disease, type C1 (Cdig2) 0.838672 (p = 0.861612) 1.21535 (p = 0.847542)
  Proteins Involved in Lipid Clearance   
Abca4 Acc: NM_00110772.1 ID: 310836 ATP-binding cassette, subfamily A (ABC1), member 4 (ABCR)
Abcb4 Acc: NM_012690.1 ID: 24891 ATP-binding cassette, subfamily B (MDR/TAP), member 4 (Mdr2, Pgy3) 1.290231 (p = 0.284859) 0.894225 (p = 0.438512)
Abcb11 Acc: NM_031760.1 ID: 83569 ATP-binding cassette, subfamily B (MDR/TAP), member 11 (Bsep, Spgp) 0.693218 (p = 0.05412) 1.397109 (p = 0.086006)
Abcc3 Acc: NM_080581.1 ID: 140668 ATP-binding cassette, subfamily C (CFTR/MRP), member 3 (Mlp2, Mrp3) 0.930144 (p = 0.499966) 0.930223 (p = 0.509623)
Abcc6 Acc: NM_031013.1 ID: 81642 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Mrp6) 1.044104 (p = 0.931493) 0.953551 (p = 0.836794)
Abcd1 Acc: NM_001108821.1 ID: 363516 ATP-binding cassette, subfamily D (ALD), member 3 (RGD1562128) 0.981591 (p = 0.867544) 0.973671 (p = 0.807543)
Abcd3 Acc: NM_012804.1 ID: 25270 ATP-binging cassette, subfamily D (ALD), member 3 (PMP70, Pxmp1) 0.775986↓ (p = 0.000407) 1.067058 (p = 0.3708)
Abcg2 Acc: NM_181381.2 ID: 312382 ATP-binding cassette, subfamily G (WHITE), member 2 (BCRP1) 0.840673 (p = 0.694657) 1.966469 (p = 0.051575)
Abcg5 Acc: NM_053754.2 ID: 114628 ATP-binding cassette, subfamily G (WHITE), member 5 1.289574 (p = 0.31897) 0.839246 (p = 0.375668)
Apoa4 Acc: NM_012737.1 ID: 25080 Apolipoprotein A-IV (Apo-AIV, ApoA-IV, ApoAIV) 1.975251↑ (p = 0.005407) 0.701419 (p = 0.119689)
Apob Acc: NM_019287.2 ID: 54225 Apolipoprotein B (Aa1064, AC1-060, Apo B-100, ApoB-100, ApoB-48) 0.90111 (p = 0.750761) 1.187596 (p = 0.618021)
Apoc2 Acc: NM_001085352.1 ID: 292697 Apolipoprotein C-II (RGD1560725) 2.057009↑ (p = 0.000592) 0.532413↓ (p = 0.000001)
Apoc3 Acc: NM_012501.1 ID: 24207 Apolipoprotein C-III (ApoC-III, apo-CIII) 0.684698↓ (p = 0.000263) 1.307856↑ (p = 0.008469)
Apoe Acc: NM_138828.2 ID: 25728 Apolipoprotein E (APOEA) 1.485673↑ (p = 0.000003) 0.778654↓ (p = 0.004399)
Apof Acc: NM_001024351.1 ID: 500761 Apolipoprotein F
Lpl Acc: NM_012498.2 ID: 24539 Lipoprotein lipase 1.135422 (p = 0.100839) 0.812916↓ (p = 0.007915)
Vldlr Acc: NM_013155.2 ID: 25696 Very low density lipoprotein receptor 0.6722↓ (p = 0.000001) Or 0.486999↓ (p = 8.10E-08) 1.096751 (p = 0.283284) Or 1.520316↑ (p = 0.002103)
Ppt1 Acc: NM_022502.2 ID: 29411 Palmitoyl-protein thioesterase 1 (Ppt) 0.9252 (p = 0.307699) 1.076592 (p = 0.320819) (p = 0.192733)
  Central Metabolic Regulators (Lipid Transcription Factors)   
Foxa1 Acc: NM_012742.1 ID: 25098 Forkhead box A1 0.828962 (p = 0.418498) 1.067287 (p = 0.72547)
Hnf4a Acc: NM_022180.1 ID: 25735 Hepatocyte nuclear factor 4, alpha (Hnf4alpha, Hnf4a) 1.208695 (p = 0.660749) 0.934321 (p = 0.806661)
Mlxipl Acc: NM_133552.1 ID: 171078 MLX interacting protein-like (ChREBP, WS-bHLH, Wbscr14, bHLHd14) 1.019326 (p = 0.831873) 1.23554↑ (p = 0.015243)
Nr1h3 Acc: NM_031627.2 ID: 58852 Nuclear receptor subfamily 1, group H, member 3 (LXRalpha) 0.898224 (p = 0.132662) 1.22274↑ (p = 0.00316)
Ppara Acc: NM_013196.1 ID: 25747 Peroxisome proliferator activated receptor alpha (PPAR) 1.042152 (p = 0.702728) 1.34318↑ (p = 0.01657)
Ppard Acc: NM_013141.2 ID: 25682 Peroxisome proliferator activated receptor delta (Pparb) 1.049635 (p = 0.640966) and 1.023475 (p = 0.858495) 1.001442 (p = 0.988966) and 0.929482 (p = 0.61664)
Pparg Acc: NM_013124.3 NM_001145366.1 NM_001145367.1 ID: 25664 Peroxisome proliferator activated receptor gamma 1.140175 (p = 0.07102) 0.96347 (p = 0.648174)
Ppargc1a Acc: NM_031347.1 ID: 83516 Peroxisome proliferator activated receptor gamma, coactivator 1 alpha (Ppargc1) 2.166136↑ (p = 0.013221) 0.49897 (p = 0.089406)
Ppargc1b Acc: NM_176075.2 ID: 291567 Peroxisome proliferator activated receptor, coactivator 1 beta (PGC1beta, Perc) 0.787663↓ (p = 0.007863) 1.092996 (p = 0.296335)
Srebf1 Acc: XM_213329.5 XM_001075680.2 ID: 78968 Sterol regulatory element binding transcription factor 1 (ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1) 0.810661↓ (p = 0.012341) and 0.885992 (p = 0.449261) 1.17608 (p = 0.063087) and 1.460992↑ (p = 0.011985)
Srebf2 Acc: NM_001033694.1 ID: 300095 Sterol regulatory element binding transcription factor 2 (SREBP-2, SREBP2-retired, Srebf2) 0.854579 (p = 0.062966) 0.964258 (p = 0.651328)
Xbp1 Acc: NM_001004210.1 ID: 289754 X-box binding protein 1 (HTF) 1.168979 (p = 0.087563) 1.080755 (p = 0.380509)