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Table 3 Adipose tissue genes responsive to feeding of a high-fructose diet (HFrD) or HFrD supplemented with NDGA (HFrD-NDGA)

From: Microarray analysis of gene expression in liver, adipose tissue and skeletal muscle in response to chronic dietary administration of NDGA to high-fructose fed dyslipidemic rats

Gene symbol/GenBank accession/Gene ID

Entrez gene name

HFrD/Chow

(Fold-change)

HFrD-NDGA/HFrD

(Fold-change)

 

Fatty Acid Transport

  

Slc27a1

Acc: NM_053580.2

ID: 94172

Soluble carrier family 27 (fatty acid transporter), member 1 (FATP1)

0.626371↓

(p = 0.000005)

1.243585↑

(p = 0.035818)

Slc27a2

Acc: NM_031736.1

ID: 65192

Soluble carrier family 27 (fatty acid transporter), member 2 (FATP2)

─

0.843521

(p = 0.704995)

 

Acyl-CoA Synthetases

  

Acsl1

Acc: NM_012820.1

ID: 25288

Acyl-CoA synthetase long-chain family member 1 (ACS, Acas, COAA, Facl2)

0.871766

(p = 0.143945)

1.022277

(p = 0.780026)

Acsl4

Acc: NM_053623.1

ID: 113976

Acyl-CoA synthetase long-chain family member 4 (ACS4, Facl4)

0.878305

(p = 0.54153)

0.964436

(p = 0.62090)

Acsm3

Acc: NM_033231.1

ID: 24763

Acyl-CoA synthetase medium-chain family member 3 (Sa, Sah)

0.987186

(p = 0.961215)

0.805024

(p = 0.413656)

Acss2

Acc: NM_001107793.1

ID: 311569

Acyl-CoA synthetase short chain family member 2 (Acss2)

0.966705

(p = 0.717211)

0.884133

(p = 0.161879)

 

Fatty Acid Oxidation

  

Cpt1a

Acc: NM_031559.2

ID: 25757

Carnitine palmitoyltransferase 1a,

liver (CPT-1a)

0.929886

(p = 0.346192)

0.971389

(p = 0.737175)

Cpt1b

Acc: NM_013200.1

ID: 25756

Carnitine palmitoyltransferase 1b,

muscle (CPT-1B, M-CPT1)

0.705154↓

(p = 0.000182)

1.080327

(p = 0.411449)

Cpt1c

Acc: NM_001034925.2

ID: 308579

Carnitine palmitoyltransferase 1c (CPT 1C, CPT1-B, CPTI-B)

0.912484

(p = 0.292825)

1.076052

(p = 0.61451)

Cpt2

Acc: NM_012930.1

ID: 25413

Carnitine palmitoyltransferase 2

(CPTII)

1.058655

(p = 0.394189)

1.03461

(p = 0.630057)

Acox1

Acc: NM_017340.2

ID: 506811

Acyl-CoA oxidase, palmitoyl (RATACOA1)

1.291301↑

(p = 0.000954)

1.086216

(p = 0.293942)

Acadl

Acc: NM_012819.1

ID: 25287

Acyl-CoA dehydrogenase, long chain (ACOADA, LCAD)

1.024278

(p = 0.778232)

0.976708

(p = 0.800795)

Acadm

Acc: NM_016986.2

ID: 24158

Acyl-CoA dehydrogenase, C-4 to C-12 straight chain (MCAD)

1.017514

(p = 0.84005)

0.917314

(p = 0.340538)

Acads

Acc: NM_022512.1

ID: 64304

Acyl-Coa dehydrogenase, C-2 to C-3 short chain (Scad)

0.645793↓

(p = 0.000149)

1.280965

(p = 0.065028)

Acadsb

Acc: NM_013084.1

ID: 25618

Acyl-CoA dehydrogenase, short/branched chain

0.775064

(p = 0.065038)

1.804414↑

(p = 0.00009)

Acadvl

Acc: NM_012891.1

ID: 25363

Acyl-CoA dehydrogenase very long chain (VLCAD)

0.785093↓

(p = 0.006311)

1.285064↑

(p = 0.003725)

Eci1

Acc: NM_017306.4

ID: 29740

Enoyl-CoA delta isomerase 1(Deci)

0.978982

(p = 0.785245)

1.134394

(p = 0.11201)

Echs1

Acc: NM_078623.2

ID: 140547

Enoy-CoA hydratase, short chain 1,

mitochondrial

0.764837↓

(p = 0.007566)

1.220593

(p = 0.080591)

Ehhadh

Acc: NM_133606.1

ID: 171142

Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase

0.64736↓

(p = 0.000141)

1.219944

(p = 0.061876)

Eci2

Acc: NM_001006966.1

ID:291075

Enoyl-CoA delta isomerase 2 (Peci)

0.899414

(p = 0.120824)

0.74287↓

(p = 0.000344)

 

Fatty Acid Synthesis/ De Novo

  
 

Lipogenesis

  

Gckr

Acc: NM_013120.2

ID: 25658

Glucokinase (hexokinase 4) regulator (GLRE)

0.755501

(p = 0.055196)

1.126918

(p = 0.490323)

Gck

Acc: NM_012565.1

ID: 24385

Glukokinase (GLUKA, RNGK2)

4.265985↑

(p = 6.89E-18)

0.302628↓

(p = 4.47E-11)

Pklr

Acc: NM_012624.3

ID: 24651

Pyruvate kinase, liver and RBC (PK1, PKL, Pklg)

2.097495↑

(p = 0.000451)

0.498737↓

(p = 0.000675)

Acly

Acc: NM_016987.2

NM_001111095.1

ID: 24159

ATP citrate lyase (ACL, Clatp)

1.295435↑

(p = 0.000403)

0.895746

(p = 0.143597)

Fasn

Acc: NM_01332.1

ID: 50761

Fatty acid synthase

1.08142

(p = 0.423101)

0.904824

(p = 0.357733)

Me1

Acc: NM_012600.2

ID: 24552

Malic enzyme 1, NADP(+)-dependent, cytosolic (MOD1)

0.847973

(p = 0.065373)

0.990152

(p = 0.920281)

Me2

Acc: NM_001111095.1

ID: 307270

Malic enzyme 2, NAD(+)-dependent, mitochondrial

—

—

Scd1

Acc: NM_139192.2

ID: 246074

Stearyol-Coenzyme A desaturase 1

9.92997↑

(p = 0.00E + 00)

0.367553↓

(p = 3.10E-28)

Elovl1

Acc: NM_001044275.1

ID: 67953.2

ELOVL fatty acid elongase 1

0.696973↓

(p = 0.)

and

1.025883

(p = 0.77018)

1.502326↑

(p = 5.63E-09)

and

1.199776

(p = 0.056696)

Elovl2

Acc: NM_001109118.1

ID: 498728

ELOVL fatty acid elongase 2

0.712072

(p = 0.389679)

0.330644

(p = 0.176175)

Elovl4

Acc: NM_001191796.1

XM_001062735.2

ID: 315851

ELOVL fatty acid elongase 4

1.053677

(p = 0.719414)

0.950803

(p = 0.678269)

Elovl5

Acc: NM_134382.1

ID: 171400

ELOVL fatty acid elongase 5 (rELO1)

1.027579

(p = 0.719414)

2.101966↑

(p = 1.14E-17)

Elovl6

Acc: NM_134383.2

ID: 171402

ELOVL fatty acid elongase 6 (Lce2, rELO2)

0.511033↓

(p = 2.11E-11)

and

1.322709↑

(p = 0.037357)

1.436011↑

(p = 0.001273)

and

0.797587

(p = 0.0795)

Fads1

Acc: NM_053445.2

ID: 84575

Fatty acid desaturase 1

1.16415

(p = 0.102452)

0.828712↓

(p = 0.042428)

Fads2

Acc: NM_031344.2

ID: 83512

Fatty acid desaturase 2 (Fadsd6)

1.036468

(p = 0.84278)

0.890867

(p = 0.485008)

Mlcyd

Acc: NM_053477.1

ID: 85239

Malonyl-CoA decarboxylase

1.06015

(p = 0.581558)

0.800024↓

(p = 0.047506)

 

Triglyceride (TG) Synthesis/VLDL-TG Assembly

  

Agpat1

Acc: NM_212458.1

ID: 406165

1-Acylglycerol-3-phosphate O-acyltransferase 1

1.733174↑

(p = 0.000011)

0.551598↓

(p = 0.000015)

Agpat2

Acc: NM_001107821.1

ID: 311821

1-Acylglycerol-3-phosphate O-acyltransferase 2

0.890825

(p = 0.154834)

0.98959

(p = 0.895733)

Agpat3

Acc: NM_001106378.1

ID: 311821

1-Acylglycerol-3-phosphate O-acyltransferase 3

0.625706↓

(p = 0.004796)

1.138055

(p = 0.352178)

Agpat6

Acc: NM_001047849.1

ID: 305166

1-Acylglycerol-3-phosphate O-acyltransferase 6 (RGD1310520)

0.668305↓

(p = 0.754188)

1.483745↑

(p = 0.000001)

Agpat9

Acc: 001025670.1

ID: 305166

1-Acylglycerol-3-phosphate O-acyltransferase 9

0.702126↓

(p = 0.007365)

1.461539↑

(p = 0.002906)

Mogat1

Acc: NM_001108803.1

ID: 363261

Monoacylglycerol O-acyltransferase 1

0.911577

(p = 0.405954)

0.977825

(p = 0.860977)

Dgat1

Acc: NM_053437.1

ID: 84497

Diacylglycerol O-acyltransferase 1 (ARAT, Dgat)

0.766526↓

(p = 0.033377)

1.35964↑

(p = 0.012554)

Dgat2

Acc: NM_001012345.1

ID: 252900

Diacylglycerol O-acyltransferase 2 (ARAT)

1.000764

(p = 0.992838)

0.890682

(p = 0.159626)

Arf3

Acc: NM_080904.2

ID: 140940

ADP-ribosylation factor 3 (AC1-253)

1.253088↑

(p = 0.000991)

0.745999↓

(p = 0.000289)

 

Cholesterol Synthesis/Metabolism

  

Acat2

Acc: NM_001006995.1

ID: 308100

Acetyl-CoA acetyltransferase 2 (Acat3, Ab2-076)

1.149942

(p = 0.064026)

0.846982↓

(p = 0.020354)

Hmgcr Acc: NM_013134.2 ID: 25675

3-Hydroxy-3-methylglutaryl-CoA reductase (3H3M)

0.614003↓ (p = 0.000734)

1.212062 (p = 0.155741)

Insig 1

Acc: NM_022392.1

ID: 64194

Insulin induced gene 1

1.046145

(p = 0.573908)

0.618888↓

(p = 0.000006)

Insig 2

Acc: NM_178091.4

ID: 288985

Insulin induced gene 2

0.823541

(p = 0.133816)

1.467193↑

(p = 0.003866)

Ldlr

Acc: NM_175762.2

ID: 300438

Low density lipoprotein receptor (LDLRA)

0.761982

(p = 0.148211)

1.204468

(p = 0.362466)

Mvk

Acc: NM_031063.1

ID: 81727

Mevalonate kinase (Lrbp)

1.024571

(p = 0.839357)

1.168772

(p = 0.150024)

Npc1

Acc: NM_001002025.11

ID: 266732

Niemann-Pick disease, type C1 (Cdig2)

0.838672

(p = 0.861612)

1.21535

(p = 0.847542)

 

Proteins Involved in Lipid Clearance

  

Abca4

Acc: NM_00110772.1

ID: 310836

ATP-binding cassette, subfamily A (ABC1), member 4 (ABCR)

─

─

Abcb4

Acc: NM_012690.1

ID: 24891

ATP-binding cassette, subfamily B (MDR/TAP), member 4 (Mdr2, Pgy3)

1.290231

(p = 0.284859)

0.894225

(p = 0.438512)

Abcb11

Acc: NM_031760.1

ID: 83569

ATP-binding cassette, subfamily B (MDR/TAP), member 11 (Bsep, Spgp)

0.693218

(p = 0.05412)

1.397109

(p = 0.086006)

Abcc3

Acc: NM_080581.1

ID: 140668

ATP-binding cassette, subfamily C (CFTR/MRP), member 3 (Mlp2, Mrp3)

0.930144

(p = 0.499966)

0.930223

(p = 0.509623)

Abcc6

Acc: NM_031013.1

ID: 81642

ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Mrp6)

1.044104

(p = 0.931493)

0.953551

(p = 0.836794)

Abcd1

Acc: NM_001108821.1

ID: 363516

ATP-binding cassette, subfamily D (ALD), member 3 (RGD1562128)

0.981591

(p = 0.867544)

0.973671

(p = 0.807543)

Abcd3

Acc: NM_012804.1

ID: 25270

ATP-binging cassette, subfamily D (ALD), member 3 (PMP70, Pxmp1)

0.775986↓

(p = 0.000407)

1.067058

(p = 0.3708)

Abcg2

Acc: NM_181381.2

ID: 312382

ATP-binding cassette, subfamily G (WHITE), member 2 (BCRP1)

0.840673

(p = 0.694657)

1.966469

(p = 0.051575)

Abcg5

Acc: NM_053754.2

ID: 114628

ATP-binding cassette, subfamily G (WHITE), member 5

1.289574

(p = 0.31897)

0.839246

(p = 0.375668)

Apoa4

Acc: NM_012737.1

ID: 25080

Apolipoprotein A-IV (Apo-AIV, ApoA-IV, ApoAIV)

1.975251↑

(p = 0.005407)

0.701419

(p = 0.119689)

Apob

Acc: NM_019287.2

ID: 54225

Apolipoprotein B (Aa1064, AC1-060, Apo B-100, ApoB-100, ApoB-48)

0.90111

(p = 0.750761)

1.187596

(p = 0.618021)

Apoc2

Acc: NM_001085352.1

ID: 292697

Apolipoprotein C-II (RGD1560725)

2.057009↑

(p = 0.000592)

0.532413↓

(p = 0.000001)

Apoc3

Acc: NM_012501.1

ID: 24207

Apolipoprotein C-III (ApoC-III, apo-CIII)

0.684698↓

(p = 0.000263)

1.307856↑

(p = 0.008469)

Apoe

Acc: NM_138828.2

ID: 25728

Apolipoprotein E (APOEA)

1.485673↑

(p = 0.000003)

0.778654↓

(p = 0.004399)

Apof

Acc: NM_001024351.1

ID: 500761

Apolipoprotein F

─

─

Lpl

Acc: NM_012498.2

ID: 24539

Lipoprotein lipase

1.135422

(p = 0.100839)

0.812916↓

(p = 0.007915)

Vldlr

Acc: NM_013155.2

ID: 25696

Very low density lipoprotein receptor

0.6722↓

(p = 0.000001)

Or

0.486999↓

(p = 8.10E-08)

1.096751

(p = 0.283284)

Or

1.520316↑

(p = 0.002103)

Ppt1

Acc: NM_022502.2

ID: 29411

Palmitoyl-protein thioesterase 1 (Ppt)

0.9252

(p = 0.307699)

1.076592

(p = 0.320819)

(p = 0.192733)

 

Central Metabolic Regulators (Lipid Transcription Factors)

  

Foxa1

Acc: NM_012742.1

ID: 25098

Forkhead box A1

0.828962

(p = 0.418498)

1.067287

(p = 0.72547)

Hnf4a

Acc: NM_022180.1

ID: 25735

Hepatocyte nuclear factor 4, alpha (Hnf4alpha, Hnf4a)

1.208695

(p = 0.660749)

0.934321

(p = 0.806661)

Mlxipl

Acc: NM_133552.1

ID: 171078

MLX interacting protein-like (ChREBP, WS-bHLH, Wbscr14, bHLHd14)

1.019326

(p = 0.831873)

1.23554↑

(p = 0.015243)

Nr1h3

Acc: NM_031627.2

ID: 58852

Nuclear receptor subfamily 1, group H, member 3 (LXRalpha)

0.898224

(p = 0.132662)

1.22274↑

(p = 0.00316)

Ppara

Acc: NM_013196.1

ID: 25747

Peroxisome proliferator activated receptor alpha (PPAR)

1.042152

(p = 0.702728)

1.34318↑

(p = 0.01657)

Ppard

Acc: NM_013141.2

ID: 25682

Peroxisome proliferator activated receptor delta (Pparb)

1.049635

(p = 0.640966)

and

1.023475

(p = 0.858495)

1.001442

(p = 0.988966)

and

0.929482

(p = 0.61664)

Pparg

Acc: NM_013124.3

NM_001145366.1

NM_001145367.1

ID: 25664

Peroxisome proliferator activated receptor gamma

1.140175

(p = 0.07102)

0.96347

(p = 0.648174)

Ppargc1a

Acc: NM_031347.1

ID: 83516

Peroxisome proliferator activated receptor gamma, coactivator 1 alpha (Ppargc1)

2.166136↑

(p = 0.013221)

0.49897

(p = 0.089406)

Ppargc1b

Acc: NM_176075.2

ID: 291567

Peroxisome proliferator activated receptor, coactivator 1 beta (PGC1beta, Perc)

0.787663↓

(p = 0.007863)

1.092996

(p = 0.296335)

Srebf1

Acc: XM_213329.5

XM_001075680.2

ID: 78968

Sterol regulatory element binding transcription factor 1 (ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1)

0.810661↓

(p = 0.012341)

and

0.885992

(p = 0.449261)

1.17608

(p = 0.063087)

and

1.460992↑

(p = 0.011985)

Srebf2

Acc: NM_001033694.1

ID: 300095

Sterol regulatory element binding transcription factor 2 (SREBP-2, SREBP2-retired, Srebf2)

0.854579

(p = 0.062966)

0.964258

(p = 0.651328)

Xbp1

Acc: NM_001004210.1

ID: 289754

X-box binding protein 1 (HTF)

1.168979

(p = 0.087563)

1.080755

(p = 0.380509)