Animal models of metabolic syndrome: a review

Nutrition & Metabolism

Table 3 Effects of different diet combinations on the development of MetS

Researchers (Year)	Types of diet	Treatment length	Strains of animal	Components of metabolic syndrome
Researchers (Year)	Types of diet	Treatment length	Strains of animal	Obesity	Hyperglycemia	Hypertension	Dyslipidemia
Poudyal et al. [29]	High-carbohydrate high-fat diet	16 weeks	Male Wistar rats	✓	✓	✓	✓
Panchal et al. [30]	High-carbohydrate high-fat diet	16 weeks	Male Wistar rats	✓	✓	✓	✓
Hao et al. [31]	High-carbohydrate high-fat diet	14 weeks	Male Wistar rats	✓	✓	✓	✓
Senaphan et al. [22]	High-carbohydrate high-fat diet	16 weeks	Male Sprague-Dawley rats	✗	✓	✓	✓
Dissard et al. [117]	High-fat high-fructose diet	32 weeks	Male C57BL/6 mice	✓	✓	✗	✓
Barrios-Ramos et al. [118]	Hypercholesterolemic diet & fructose drinking water	4 weeks	Male Wistar rats	✓	✓	✓	✓
Gancheva et al. [116]	High-fat high-fructose diet	8 weeks	Male Wistar rats	✓	✓	-	✓
Yang et al. [119]	High-fat high sucrose diet	4 weeks	Male C57BL/6 J mice	✓	✓	-	✓
Zhou et al. [120]	High-sucrose high-fat diet	48 weeks	Male Sprague-Dawley rats	✓	✓	-	✓

Table represents the effects of different diet combinations on each component of MetS. The symbol ‘✓’ and ‘✗’ indicate the presence and absence of significant effect of the sign of MetS respectively, while ‘-’ indicates the effects on the component not being evaluated in the study

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