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Table 2 Independent samples t-tests comparing time-corrected paraxanthine/caffeine ratios by age, body mass index, caffeine intake, contraceptive pill, CYP1A2 inducibility, gender, insulin administration, long-term medication, smoking status

From: Assessment of CYP1A2 enzyme activity in relation to type-2 diabetes and habitual caffeine intake

  Group N Time-corrected paraxanthine/caffeine ratio p value
Age ≤59.3 years 77 0.604 (±0.364) 0.290
>59.3 years 126 0.561 (±0.438)
BMI ≤24.9 kg/m2 117 0.560 (±0.415) 0.580
>24.9 kg/m2 84 0.603 (±0.408)
Caffeine Intake ≤288 mg/day 139 0.535 (±0.431) 0.010
>288 mg/day 64 0.669 (±0.350)
Contraceptive Pill No 194 0.579 (±0.417) 0.979
Yes 9 0.545 (±0.282)
CYP1A2 Inducibility Less (C/A and C/C genotypes) 103 0.552 (±0.430) 0.284
High (A/A genotype) 97 0.609 (±0.394)
Gender Male 87 0.631 (±0.467) 0.237
Female 116 0.537 (±0.360)
Insulin Administration No 184 0.557 (±0.414) 0.016
Yes 19 0.770 (±0.336)
Medication No 74 0.510 (±0.311) 0.187
Yes 129 0.616 (±0.456)
Smoking Status Non Smoking 182 0.573 (±0.410) 0.896
Smoking 21 0.617 (±0.430)
  1. Values are given as mean (±SD). Independent samples t-tests were applied to time-corrected paraxanthine/caffeine ratios transformed by square root to approximate a normal distribution. Statistical data reported assumed equal variances. P-values reflected a 2-tailed test. Results are reported to 3 decimal places