Skip to main content

Advertisement

Table 3 Association of ACE(I/D) genotype/allele frequencies with hypertension, obesity, insulin resistance and metabolic syndrome

From: Angiotensin-converting enzyme insertion/deletion polymorphism association with obesity and some related disorders in Egyptian females: a case-control observational study

Groups (n) DD ID + II Significance D allele I allele Significance
OH (28) 19 (67.9 %) 9 (32.1 %) χ 2 = 2.898 p = 0.41 45 (80.4 %) 11 (19.6 %) χ 2 = 2.64 p = 0.45
ON (23) 14 (60.9 %) 9 (39.1 %) 35 (76.1 %) 11 (23.9 %)
LH (12) 9 (75.0 %) 3 (25.0 %) 21 (87.5 %) 3 (12.5 %)
LN (17) 8 (47.1 %) 9 (53.9 %) 24 (70.6 %) 10 (29.4 %)
Obese BMI (51) 33 (64.7 %) 18 (35.3 %) χ 2 = 0.29 p = 0.59 80 (78.4 %) 22 (21.6 %) χ 2 = 0.015 p = 0.90
Normal BMI (29) 17 (58.6 %) 12 (41.4 %) 45 (77.6 %) 13 (22.4 %)
Large WC (57) 37 (64.9 %) 20 (35.1 %) χ 2 = 0.49 p = 0.48 90 (78.9 %) 24 (21.1 %) χ 2 = 0.16 p = 0.69
Normal WC (23) 13 (56.5 %) 10 (43.5 %) 35 (76.1 %) 11 (23.9 %)
Large WHR (55) 37 (67.3 %) 18 (32.7 %) χ 2 = 1.71 p = 0.19 89 (80.9 %) 21 (19.1 %) χ 2 = 1.6 p = 0.21
Normal WHR (25) 13 (52.0 %) 12 (48.0 %) 36 (72.0 %) 14 (28.0 %)
Large WHtR (69) 43 (62.3 %) 26 (37.7 %) Fisher's Exact: p = 1.00 107 (77.5 %) 31 (22.5 %) χ 2 = 0.20 p = 0.65
Normal WHtR (11) 7 (63.6 %) 4 (36.4 %) 18 (81.8 %) 4 (18.2 %)
Large C-index (44) 32 (72.7 %) 12 (27.3 %) χ 2 = 3.26 p = 0.071 74 (84.1 %) 14 (15.9 %) χ 2 = 3.07  p = 0.08
Normal C-index (36) 18 (50.0 %) 18 (50.0 %) 51 (70.8 %) 21 (29.2 %)
Hypertensive (40) 28 (70.0 %) 12 (30.0 %) χ 2 = 1.92 p = 0.17 66 (82.5 %) 14 (17.5 %) χ 2 = 1.79 p = 0.18
Normotensive (40) 22 (55.0 %) 18 (45.0 %) 59 (73.8 %) 21 (26.2 %)
Insulin resistant (62) 39 (62.9 %) 23 (37.1 %) χ 2 = 0.02 p = 0.89 99 (79.8 %) 25 (20.2 %) χ 2 = 0.95 p = 0.33
Insulin sensitive (18) 11 (61.1 %) 7 (38.9 %) 26 (72.2 %) 10 (27.8 %)
Positive MetS (45) 27 (60.0 %) 18 (40.0 %) χ 2 = 0.27 p = 0.6 69 (76.7 %) 21 (23.3 %) χ 2 = 0.26 p = 0.61
No MetS (35) 23 (65.7 %) 12 (34.3 %) 56 (80.0 %) 14 (20.0 %)
  1. Data are presented as number (percentage), n (%)
  2. OH obese hypertensive subjects, ON obese normotensive subjects, LH lean hypertensive subjects, LN lean normotensive control subjects, BMI body mass index, WC waist circumference, WHR waist/hip ratio, WHtR waist/height ratio, C-index conicity index, MetS metabolic syndrome, DD homozygous deletion genotype, ID heterozygous insertion deletion genotype, II homozygous insertion genotype, D deletion allele, I insertion allele