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Table 6 Associations of obesity (based on different obesity indices) with hypertension and insulin resistance layered by I/D genotypes

From: Angiotensin-converting enzyme insertion/deletion polymorphism association with obesity and some related disorders in Egyptian females: a case-control observational study

Polymorph Obesity Hypertension Insulin resistance
Hypertensive Normotensive Resistant Sensitive
DD Large WHR (37) 23 (62.2 %) 14 (37.8 %) 30 (81.1 %) 7 (18.9 %)
Normal WHR (13) 5 (38.5 %) 8 (61.5 %) 9 (69.2 %) 4 (30.8 %)
  χ 2 = 2.19, p = 0.14 Fisher's exact: p = 0.45
I-carriers Large WHR (18) 11 (61.1 %) 7 (38.9 %) 14 (77.8 %) 4 (22.2 %)
Normal WHR (12) 1 (8.3 %) 11 (91.7 %) 9 (75.0 %) 3 (25.0 %)
  Fisher's exact: p = 0.007* OR = 17.29, CI = 1.81–164.96 Fisher's exact: p = 1.00
DD Large C-index (32) 19 (59.4 %) 13 (40.6 %) 25 (78.1 %) 7 (21.9 %)
Normal C-index (18) 9 (50.0 %) 9 (50.0 %) 14 (77.8 %) 4 (22.2 %)
  χ 2 = 0.41, p = 0.52 Fisher's exact: p = 1.00
I-carriers Large C-index (12) 8 (66.7 %) 4 (33.3 %) 9 (75.0 %) 3 (25.0 %)
Normal C-index (18) 4 (22.2 %) 14 (77.8 %) 14 (77.8 %) 4 (22.2 %)
  Fisher's exact: p = 0.024* OR = 7.00, CI = 1.36–35.93 Fisher's exact: p = 1.00
DD Obese BMI (33) 19 (57.6 %) 14 (42.4 %) 31 (91.2 %) 3 (8.8 %)
Normal BMI (17) 9 (52.9 %) 8 (47.1 %) 8 (50.0 %) 8 (50.0 %)
  χ 2 = 0.10, p = 0.75 Fisher's exact: p = 0.004* OR = 8.89, CI = 1.94–40.71
I-carriers Obese BMI (18) 9 (50.0 %) 9 (50.0 %) 15 (83.3 %) 3 (16.7 %)
Normal BMI (12) 3 (25.0 %) 9 (75.0 %) 8 (66.7 %) 4 (33.3 %)
  Fisher's exact: p = 0.26 Fisher's exact: p = 0.39
DD Large WC (37) 23 (62.2 %) 14 (40.0 %) 33 (89.2 %) 4 (10.8 %)
Normal WC (13) 5 (38.5 %) 8 (53.3 %) 6 (46.2 %) 7 (53.8 %)
  χ 2 = 2.19, p = 0.14 Fisher's exact: p = 0.003* OR = 9.63, CI = 2.14–43.36
I-carriers Large WC (20) 10 (50.0 %) 10 (50.0 %) 17 (85.0 %) 3 (15.0 %)
Normal WC (10) 2 (20.0 %) 8 (80.0 %) 6 (60.0 %) 5 (40.0 %)
  Fisher's exact: p = 0.24 Fisher's exact: p = 0.18
DD Large WHtR (43) 25 (58.1 %) 18 (41.9 %) 36 (83.7 %) 7 (16.3 %)
Normal WHtR (7) 3 (42.9 %) 4 (57.1 %) 3 (42.9 %) 4 (57.1 %)
  Fisher's exact: p = 0.68 Fisher's exact: p = 0.034* OR = 6.86, CI = 1.25–37.61
I-carriers Large WHtR (26) 12 (46.2 %) 14 (53.8 %) 19 (73.1 %) 7 (26.9 %)
Normal WHtR (4) 0 (0 %) 4 (100 %) 4 (100 %) 0 (0 %)
  Fisher's exact: p = 0.13 Fisher's exact: p = 0.55
  1. Data are presented as number (percentage)
  2. *: significant difference at p < 0.05
  3. DD homozygous deletion genotype, I-carriers homozygous and heterozygous insertion genotypes, BMI: body mass index, WC waist circumference, WHtR waist/height ratio, WHR waist/hip ratio, C-index conicity index, χ 2 chi square, OR odds ratio, CI confidence intervals