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Table 3 Glycemic and hormonal responses during oral glucose tolerance tests (OGTT) in study arm 2

From: Hormonal responses to non-nutritive sweeteners in water and diet soda

Variable Seltzer water (mean ± SD) Diet Rite Cola™ (mean ± SD) Diet Mountain Dew™ (mean ± SD) Sucralose and Ace-K (mean ± SD) p-value (ANOVA)
Active GLP-1 AUC (pmol/L/120 min) 1142.9 ± 702.8 1274.5 ± 781.8** 1268.5 ± 739.7 1173.2 ± 755.0 0.087
Active GLP-1 Peak (pmol/L) 14.3 ± 8.1 16.1 ± 9.9 14.5 ± 6.5 14.4 ± 8.6 0.53
Time to Active GLP-1 Peak (minutes) 24.2 ± 24.7 20.0 ± 13.6 23.0 ± 13.7 25.2 ± 22.9 0.73
GIP AUC (pg/mL/120 min) 30926.1 ± 14737.3 33652.6 ± 22175.9 31624.2 ± 16665.2 32132.3 ± 20268.2 0.62
GIP Peak (pg/mL) 335.8 ± 158.9 367.5 ± 260.1 329.6 ± 167.1 351.4 ± 266.5 0.43
Time to GIP Peak (minutes) 60.3 ± 35.5 55 ± 30.7 62.3 ± 40.1 55.5 ± 35.2 0.76
Glucose AUC (umol/L/120 min) 850.2 ± 142.8 873.3 ± 171.4 843.3 ± 170.5 880.6 ± 163.2 0.40
Glucose Peak (umol/L) 8.0 ± 1.4 8.4 ± 1.6 8.1 ± 1.7 8.4 ± 1.6 0.25
Time to Glucose Peak (minutes) 43.5 ± 28.8 44 ± 32.0 37.0 ± 24.4 41.3 ± 24.9 0.45
Insulin AUC (pmol/L/120 min) 55538.4 ± 28652.2 69164.8 ± 44218.6 67883.8 ± 41168.7 68039.7 ± 44373.7 0.53
Insulin Peak (pmol/mL) 734.7 ± 409.9 876.1 ± 490.8 862.4 ± 521.1 882.6 ± 535.5 0.33
Time to Insulin Peak (minutes) 53.9 ± 35.3 53.4 ± 33.1 48.6 ± 29.5 51.0 ± 30.0 0.74
C-Peptide AUC (nmol/L/120 min) 327.7 ± 105.1 342.7 ± 105.9 336.3 ± 109.5 338.7 ± 108.5 0.69
C-Peptide Peak (nmol/L) 3.4 ± 1.1 3.6 ± 1.1 3.5 ± 1.2 3.6 ± 1.2 0.31
Time to C-Peptide Peak (minutes) 76.8 ± 33.7 67.7 ± 30.9 66.0 ± 34.4 67.1 ± 31.9 0.31
Insulin Sensitivity Index 1.29 ± 1.17 1.30 ± 1.06 1.50 ± 1.24 1.43 ± 1.04 0.87
  1. **p < 0.05, *p < 0.01 data presented as pairwise comparisons between each NNS preload and the seltzer water control