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Table 4 Status of the target gene expression, diets and sex of offspring

From: Comparison of maternal isocaloric high carbohydrate and high fat diets on osteogenic and adipogenic genes expression in adolescent mice offspring

Gene

Variable’s level

Ba

SE

p value

OR (95 % CI)

Runx2

Diets

LF-HCD

-

-

0.9

1

HF-LCD

−40.6

1.3

0.001 (0.001, 0.001)

Sex

Female

-

-

0.9

1

Male

−18.4

9.1

0.001 (0.001, 0.001)

OPG

Diets

LF-HCD

-

-

<0.001*

1

HF-LCD

−3.7

0.95

0.02 (0.004, 0.16)

Sex

Female

-

-

0.19

1

Male

1.2

0.89

3.2 (0.55, 18.3)

OPG/RANK-L

Diets

LF-HCD

-

-

0.12

1

HF-LCD

−1.01

0.65

0.36 (0.1, 1.31)

Sex

Female

-

-

0.02*

1

Male

−1.6

0.7

0.2 (0.05, 0.78)

Ctnnb1

Diets

LF-HCD

-

-

<0.001*

1

HF-LCD

−3.5

0.88

0.03 (0.005, 0.17)

Sex

Female

-

-

0.6

1

Male

0.44

0.82

1.5 (0.31, 7.73)

PPARɤ2

Diets

LF-HCD

-

-

0.004*

1

HF-LCD

1.95

0.68

7.1 (1.83, 27.1)

Sex

Female

-

-

0.13

1

Male

1.04

0.69

2.8 (0.73, 11.1)

FASN

Diets

LF-HCD

-

-

0.99

1

HF-LCD

21.9

817

0.001 (0.001, 0.001)

Sex

Female

-

-

0.56

1

Male

0.51

0.87

1.66 (0.3, 9.3)

AdipoQ

Diets

LF-HCD

-

-

<0.001*

1

HF-LCD

2.8

0.74

15.8 (3.7, 67.4)

Sex

Female

-

-

0.4

1

Male

−0.62

0.74

0.53 (0.125, 2.3)

Lep

Diets

LF-HCD

-

-

0.99

1

HF-LCD

40.1

102

0.001 (0.001, 0.001)

Sex

Female

-

-

0.99

1

Male

−19.7

72

0.001 (0.001, 0.001)

LPL

Diets

LF-HCD

-

-

0.03*

1

HF-LCD

1.44

0.68

4.2 (1.1, 16.2)

Sex

Female

-

-

0.87

1

Male

0.11

0.66

1.1 (0.3, 4.1)

  1. p values are calculated with the logistic regression model
  2. LF-HCD low fat-high carbohydrate diet, HF-LCD high fat-low carbohydrate diet, OR odds ratio, CI confidence interval, OPG osteoprotegerin, RANK-L nuclear factor (NF-kB) ligand, PPRRɤ2 Peroxisome proliferator-activated receptor gamma 2, FASN fatty acid synthase, AdipoQ adiponectin, Lep leptin, LPL lipoprotein lipase
  3. aEstimated regression coefficients and corresponded standard errors of logistic regression model
  4. *significant differences adjusted for maternal diet and/or sex of offspring