Skip to main content

Advertisement

Table 4 Status of the target gene expression, diets and sex of offspring

From: Comparison of maternal isocaloric high carbohydrate and high fat diets on osteogenic and adipogenic genes expression in adolescent mice offspring

Gene Variable’s level Ba SE p value OR (95 % CI)
Runx2 Diets LF-HCD - - 0.9 1
HF-LCD −40.6 1.3 0.001 (0.001, 0.001)
Sex Female - - 0.9 1
Male −18.4 9.1 0.001 (0.001, 0.001)
OPG Diets LF-HCD - - <0.001* 1
HF-LCD −3.7 0.95 0.02 (0.004, 0.16)
Sex Female - - 0.19 1
Male 1.2 0.89 3.2 (0.55, 18.3)
OPG/RANK-L Diets LF-HCD - - 0.12 1
HF-LCD −1.01 0.65 0.36 (0.1, 1.31)
Sex Female - - 0.02* 1
Male −1.6 0.7 0.2 (0.05, 0.78)
Ctnnb1 Diets LF-HCD - - <0.001* 1
HF-LCD −3.5 0.88 0.03 (0.005, 0.17)
Sex Female - - 0.6 1
Male 0.44 0.82 1.5 (0.31, 7.73)
PPARɤ2 Diets LF-HCD - - 0.004* 1
HF-LCD 1.95 0.68 7.1 (1.83, 27.1)
Sex Female - - 0.13 1
Male 1.04 0.69 2.8 (0.73, 11.1)
FASN Diets LF-HCD - - 0.99 1
HF-LCD 21.9 817 0.001 (0.001, 0.001)
Sex Female - - 0.56 1
Male 0.51 0.87 1.66 (0.3, 9.3)
AdipoQ Diets LF-HCD - - <0.001* 1
HF-LCD 2.8 0.74 15.8 (3.7, 67.4)
Sex Female - - 0.4 1
Male −0.62 0.74 0.53 (0.125, 2.3)
Lep Diets LF-HCD - - 0.99 1
HF-LCD 40.1 102 0.001 (0.001, 0.001)
Sex Female - - 0.99 1
Male −19.7 72 0.001 (0.001, 0.001)
LPL Diets LF-HCD - - 0.03* 1
HF-LCD 1.44 0.68 4.2 (1.1, 16.2)
Sex Female - - 0.87 1
Male 0.11 0.66 1.1 (0.3, 4.1)
  1. p values are calculated with the logistic regression model
  2. LF-HCD low fat-high carbohydrate diet, HF-LCD high fat-low carbohydrate diet, OR odds ratio, CI confidence interval, OPG osteoprotegerin, RANK-L nuclear factor (NF-kB) ligand, PPRRɤ2 Peroxisome proliferator-activated receptor gamma 2, FASN fatty acid synthase, AdipoQ adiponectin, Lep leptin, LPL lipoprotein lipase
  3. aEstimated regression coefficients and corresponded standard errors of logistic regression model
  4. *significant differences adjusted for maternal diet and/or sex of offspring