Fig. 1

Caloric intake, body weight, and body composition of 14 female C57BL/6J mice fed either regular chow feed (Control) or a low-carbohydrate high-fat (LCHF) diet. Mice fed the LCHF diet maintained their body weight until the end of the study but increased their fat mass. a Daily and total caloric intake. During the final week, mice fed the LCHF diet consumed significantly fewer total calories than mice fed the control diet. SD < 8.8 % for both groups at each single data point. b Body weight was measured every third day. SD < 6.8 % and < 6.2 % at each single data point for the control and LCHF-fed mice, respectively. c Body composition and the percentage of total body weight measured prior to the diet switch (week 0) and after 2 and 4 weeks on the diet. Data are presented as the mean ± SD with n = 7 in each group. *p < 0.05, ***p < 0.001 vs. control at the indicated time point; ^††† p < 0.001 vs. week 0 within each diet group; ^‡ p < 0.05 vs. week 2 within each diet group