Fig. 2

Female C57BL/6J mice fed a low-carbohydrate high-fat (LCHF) diet had impaired cardiac function and early signs of myocardial triglyceride accumulation compared with mice fed regular chow feed (Control). a Cardiac output. b Stroke volume. c Triglyceride content per gram wet cardiac tissue. d Lipoprotein lipase (LPL) activity in cardiac tissue. e Relative expression of genes involved in the transport of fatty acid and glucose in cardiac tissue after normalization to expression in control mice. f Septum wall thickness at diastole and systole at baseline and after 4 weeks on each diet. Data are presented as mean ± SD with n = 7 in each group. **p < 0.01 vs. control at the indicated time point; ^††† p < 0.001 vs. week 0 within each diet group