Metabolic gene expression profile in circulating mononuclear cells reflects obesity-associated metabolic inflexibility

Table 1 Baseline characteristics of study participants after a 10-h overnight fast

	Lean subjects	Obese subjects	P	Adjusted P *
Age (years)	23.2 ± 0.2	28.6 ± 1.4	0.002
BMI (kg/m²)	22.0 ± 0.2	30.2 ± 0.8	<0.001	<0.001
Waist Circumference (cm)	79.9 ± 0.5	100.8 ± 1.0	<0.001	<0.001
Fasting Blood Glucose (mmol/l)	4.33 ± 0.05	4.68 ± 0.12	0.026	0.459
Fasting Serum Insulin (mU/l)	4.31 ± 0.52	21.04 ± 2.27	<0.001	<0.001
Fasting Total Cholesterol (mmol/l)	5.09 ± 0.27	5.28 ± 0.40	0.697	0.791
Fasting LDL-Cholesterol (mmol/l)	3.09 ± 0.29	3.20 ± 0.35	0.823	0.730
Fasting HDL-Cholesterol (mmol/l)	1.71 ± 0.08	1.19 ± 0.06	0.001	0.005
Fasting Triglyceride (mmol/l)	0.62 ± 0.07	1.98 ± 0.24	<0.001	0.007
Fasting NEFA (mmol/l)^a	0.41 ± 0.04	0.49 ± 0.03	0.037	0.392
HOMA-IR	0.83 ± 0.10	4.34 ± 0.41	<0.001	<0.001
Fasting RQ	0.79 ± 0.01	0.78 ± 0.01	0.784	0.463

Data are presented as the means ± SEM; * age-adjusted, ^alog transformed comparison of the mean; BMI body mass index, LDL low-density lipoprotein, HDL high-density lipoprotein, HOMA-IR homeostasis model assessment for insulin resistance, NEFA nonesterified fatty acids, RQ respiratory quotient

ISSN: 1743-7075