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Table 2 Changes in the platelet chemokine levels in the participants

From: Effects of purified anthocyanin supplementation on platelet chemokines in hypocholesterolemic individuals: a randomized controlled trial

 

Placebo (n = 73)

Anthocyanins (n = 73)

P-valueb

Baseline

12 wk

24 wk

Mean change,% (95% CI)a

Baseline

12 wk

24 wk

Mean change,% (95% CI)a

CXCL7 (ng/ml)

167.63 ± 38.78

165.82 ± 37.83

166.20 ± 31.92

4.22

170.52 ± 44.86

157.76 ± 43.21

138.83 ± 30.49c

−12.32

0.011

(−2.33 to 11.05)

(−19.25 to −5.00)d

CXCL5 (pg/ml)

159.43 ± 29.35

157.85 ± 31.80

157.32 ± 29.74

1.93

160.40 ± 36.26

150.78 ± 28.98 c

137.61 ± 26.14c

−9.95

0.006

(−4.18 to 9.28)

(−15.84 to −3.56)d

CXCL8 (pg/ml)

22.97 ± 2.73

22.91 ± 2.51

22.97 ± 4.24

0.66

22.93 ± 1.96

22.32 ± 1.61 c

21.40 ± 1.07c

−6.07

0.016

(−2.99 to 4.88)

(−8.15 to −4.23)d

CXCL12 (ng/mL)

2.16 ± 0.53

2.15 ± 0.51

2.14 ± 0.46

5.43

2.19 ± 0.56

2.11 ± 0.34

1.86 ± 0.47c

−8.11

0.020

(−2.03 to 14.16)

(−15.98 to −0.30)d

CCL2 (pg/mL)

504.99 ± 165.34

502.68 ± 157.33

515.76 ± 132.04

12.84

502.97 ± 139.91

476.96 ± 113.74

414.61 ± 87.14c

−11.63

0.014

(1.05 to 27.23)

(−18.16 to −4.85)d

CXCL4L1 (pg/ml)

124.29 ± 88.87

134.00 ± 69.82

135.16 ± 75.07

0.08

126.52 ± 67.05

126.44 ± 75.21

112.27 ± 86.78

−0.80

0.769

(−0.21 to 0.35)

(−2.07 to 0.06)

CXCL1 (ng/ml)

20.96 ± 3.15

21.94 ± 2.38

22.92 ± 3.67

0.07

21.30 ± 4.71

21.00 ± 3.37

21.07 ± 1.79

−0.02

0.529

(−0.06 to 0.19)

(−0.24 to 0.16)

PAI-1 (ng/ml)

101.52 ± 41.81

106.13 ± 48.55

108.84 ± 14.31

0.08

104.07 ± 52.84

107.16 ± 36.38

99.62 ± 42.35

−0.44

0.888

(−0.10 to 0.29)

(−1.34 to 0.20)

MIF (ng/ml)

32.91 ± 10.02

30.46 ± 9.54

29.51 ± 14.58

−9.90

32.69 ± 13.94

31.26 ± 8.53

26.93 ± 10.56

2.65

0.801

(−25.96 to 7.13)

(−32.90 to 39.14)

  1. The data are expressed as the mean ± SD
  2. No significant differences in any variable were observed between the two groups at baseline, as determined using unpaired Student’s t-test
  3. aCalculated as (value at week 24 – value at baseline)/value at baseline × 100
  4. bThe effects of the intervention on these variables were evaluated by repeated-measures ANOVA
  5. c P < 0.05 vs. baseline, as assessed by paired Student’s t-test
  6. d P < 0.05 vs. percentage changes in the placebo group, as assessed by unpaired Student’s t-test