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Table 4 Changes in the inflammatory cytokine levels in the participants

From: Effects of purified anthocyanin supplementation on platelet chemokines in hypocholesterolemic individuals: a randomized controlled trial

  Placebo (n = 73) Anthocyanin (n = 73) P-valueb
Baseline 12 wk 24 wk Mean change, % (95% CI)a Baseline 12 wk 24 wk Mean change, % (95% CI)a
hsCRP (mg/L) 2.26 2.23 2.19 −2.5 2.25 1.95 1.74 −21.6 0.001
(0.97 to 3.72) (1.08 to 3.76) (0.93 to 3.82) (−7.0 to 2.1) (1.06 to 4.25) (0.92 to 2.84)c (0.86 to 2.60) (–37.5 to –5.7)d
TNF-α (pg/mL) 18.0 ± 6.0 19.1 ± 6.7 18.5 ± 5.4 2.8 (−3.4 to 9.1) 18.7 ± 6.4 17.9 ± 5.1 18.4 ± 5.6 −1.6 (−5.6 to 3.4) 0.673
IL-1β (pg/mL) 4.77 ± 1.71 4.23 ± 0.91 4.71 ± 1.60 −1.3 (−5.3 to 2.7) 5.18 ± 2.11 4.62 ± 1.20c 4.51 ± 1.60c −12.8 (−24.4 to −1.2)d 0.019
sP-selectin (ng/mL) 149.9 ± 42.7 139.9 ± 39.0 139.9 ± 39.0 −2.4 (−15.4 to 10.6) 150.9 ± 37.0 144.4 ± 35.3 134.6 ± 32.8 −5.9 (−17.7 to 6.0)d 0.027
  1. The data are expressed as the mean ± SD
  2. No significant differences in any variable were observed between the two groups at baseline, as determined using unpaired Student’s t-test
  3. a Calculated as (value at week 24 – value at baseline)/value at baseline × 100
  4. b The effects of the intervention on these variables were evaluated by repeated-measures ANOVA
  5. c P < 0.05 vs. baseline, as assessed by paired Student’s t-test
  6. d P < 0.05 vs. percentage changes in the placebo group, as assessed by unpaired Student’s t-test
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