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Table 4 Changes in the inflammatory cytokine levels in the participants

From: Effects of purified anthocyanin supplementation on platelet chemokines in hypocholesterolemic individuals: a randomized controlled trial

 

Placebo (n = 73)

Anthocyanin (n = 73)

P-valueb

Baseline

12 wk

24 wk

Mean change, % (95% CI)a

Baseline

12 wk

24 wk

Mean change, % (95% CI)a

hsCRP (mg/L)

2.26

2.23

2.19

−2.5

2.25

1.95

1.74

−21.6

0.001

(0.97 to 3.72)

(1.08 to 3.76)

(0.93 to 3.82)

(−7.0 to 2.1)

(1.06 to 4.25)

(0.92 to 2.84)c

(0.86 to 2.60)

(–37.5 to –5.7)d

TNF-α (pg/mL)

18.0 ± 6.0

19.1 ± 6.7

18.5 ± 5.4

2.8 (−3.4 to 9.1)

18.7 ± 6.4

17.9 ± 5.1

18.4 ± 5.6

−1.6 (−5.6 to 3.4)

0.673

IL-1β (pg/mL)

4.77 ± 1.71

4.23 ± 0.91

4.71 ± 1.60

−1.3 (−5.3 to 2.7)

5.18 ± 2.11

4.62 ± 1.20c

4.51 ± 1.60c

−12.8 (−24.4 to −1.2)d

0.019

sP-selectin (ng/mL)

149.9 ± 42.7

139.9 ± 39.0

139.9 ± 39.0

−2.4 (−15.4 to 10.6)

150.9 ± 37.0

144.4 ± 35.3

134.6 ± 32.8

−5.9 (−17.7 to 6.0)d

0.027

  1. The data are expressed as the mean ± SD
  2. No significant differences in any variable were observed between the two groups at baseline, as determined using unpaired Student’s t-test
  3. a Calculated as (value at week 24 – value at baseline)/value at baseline × 100
  4. b The effects of the intervention on these variables were evaluated by repeated-measures ANOVA
  5. c P < 0.05 vs. baseline, as assessed by paired Student’s t-test
  6. d P < 0.05 vs. percentage changes in the placebo group, as assessed by unpaired Student’s t-test
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Nutrition & Metabolism

ISSN: 1743-7075

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