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Fig. 2 | Nutrition & Metabolism

Fig. 2

From: Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling

Fig. 2

Glucose tolerance test after long-term feeding of an obesogenic high fat diet. Blood glucose levels during an intraperitoneal glucose tolerance test (ipGTT) in wild type (wt), Epac1 deficient (Epac1−/−) and Epac2 deficient (Epac2−/−) mice; before initiation of the feeding experiment (baseline) (a, left panel), and after 28 weeks of exposure to either a normal chow diet (ND) or a high fat diet (HFD) in Epac1−/− (b, left panel) and Epac2−/− mice (c, left panel). The area under the curves (AUC) indicate the total blood glucose variation during the ipGTT (a-c, right panels). Values are mean ± SEM. *p < 0.05 vs. wt ND. p < 0.05 vs. Epac1−/− ND. ¤ p < 0.05 vs. Epac1−/− HFD. $ p < 0.05 vs. Epac2−/− ND. £ p < 0.05 vs. Epac2−/− HFD

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