Fig. 2

Glucose tolerance test after long-term feeding of an obesogenic high fat diet. Blood glucose levels during an intraperitoneal glucose tolerance test (ipGTT) in wild type (wt), Epac1 deficient (Epac1^−/−) and Epac2 deficient (Epac2^−/−) mice; before initiation of the feeding experiment (baseline) (a, left panel), and after 28 weeks of exposure to either a normal chow diet (ND) or a high fat diet (HFD) in Epac1^−/− (b, left panel) and Epac2^−/− mice (c, left panel). The area under the curves (AUC) indicate the total blood glucose variation during the ipGTT (a-c, right panels). Values are mean ± SEM. *p < 0.05 vs. wt ND. ^€ p < 0.05 vs. Epac1^−/− ND. ^¤ p < 0.05 vs. Epac1^−/− HFD. ^$ p < 0.05 vs. Epac2^−/− ND. ^£ p < 0.05 vs. Epac2^−/− HFD