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Fig. 5 | Nutrition & Metabolism

Fig. 5

From: Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling

Fig. 5

Cardiac rate-pressure product in the ex vivo perfused mice hearts. The rate-pressure product were calculated (RPP = LVSP x HR) at stabilization and during the post-ischemic reperfusion period in mice exposed to long-term feeding of a ND or HFD in: a wild type (wt), b Epac1 deficient (Epac1−/−) and c Epac2 deficient (Epac2−/−) mice hearts. Values are mean ± SEM. * p < 0.05 vs. wt ND. £ p < 0.05 vs. Epac2−/− HFD. # p < 0.05 vs. corresponding pre-ischemic stabilization value

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