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Table 2 Hemodynamic parameters

From: Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling

 

Group

Stab

5’ rep

15’ rep

30’ rep

45’ rep

60’ rep

Number

LVDP (mmHg)

wt ND

101 ± 7

56 ± 13#

63 ± 7#

56 ± 4#

54 ± 5#

51 ± 4#

8

wt HFD

119 ± 8

94 ± 9#

104 ± 8

95 ± 5*

85 ± 5#,*

74 ± 4#

16

Epac1−/− ND

116 ± 4

72 ± 14#

73 ± 7#

75 ± 8#

77 ± 11#

71 ± 8#

6

Epac1−/− HFD

122 ± 14

89 ± 23#

81 ± 16#

76 ± 15#

82 ± 13#

69 ± 11#

6

Epac2−/− ND

101 ± 8

90 ± 8

92 ± 14

89 ± 12

87 ± 12

88 ± 13

6

Epac2−/− HFD

108 ± 7

81 ± 8

92 ± 12

91 ± 9

80 ± 8

78 ± 9

10

HR (bpm)

wt ND

255 ± 22

164 ± 28

173 ± 31

193 ± 29

204 ± 31

208 ± 27

8

wt HFD

260 ± 20

215 ± 24

214 ± 24

196 ± 20$

195 ± 20

211 ± 24

16

Epac1−/− ND

268 ± 28

269 ± 44

271 ± 42

269 ± 45

272 ± 39

288 ± 39

6

Epac1−/− HFD

288 ± 24

259 ± 57

247 ± 38

254 ± 37

233 ± 43

244 ± 41

6

Epac2−/− ND

300 ± 39

313 ± 41

325 ± 60

338 ± 50

317 ± 51

315 ± 42

6

Epac2−/− HFD

316 ± 29

295 ± 33

280 ± 37

272 ± 27

288 ± 29

286 ± 27

10

dP/dtmin (mmHg/s)

wt ND

−3926 ± 629

−1287 ± 365#

−1549 ± 334#

−1511 ± 308#

−1642 ± 248#

−1954 ± 646#

8

wt HFD

−4973 ± 363

−2742 ± 237#

−3096 ± 298#

−3024 ± 265#*

−2804 ± 239#

−2501 ± 183#

16

Epac1−/− ND

−4342 ± 325

−2378 ± 512#

−2408 ± 271#

−2464 ± 209#

−2458 ± 270#

−2457 ± 244#

6

Epac1−/− HFD

−4620 ± 691

−2633 ± 664

−2629 ± 553

−2522 ± 632

−2632 ± 539

−2205 ± 464#

6

Epac2−/− ND

−4325 ± 159

−3026 ± 342#

−2866 ± 298#

−3243 ± 260#*

−3106 ± 182#

−3284 ± 243#

6

Epac2−/− HFD

−5031 ± 715

−2997 ± 659#

−3352 ± 601*

−3074 ± 390#*

−3037 ± 381#*

−2771 ± 327#

10

dP/dtmax (mmHg/s)

wt ND

6327 ± 997

2701 ± 790#

3149 ± 648#

2717 ± 368#

2635 ± 297#

2465 ± 355#

8

wt HFD

7195 ± 846

4632 ± 451#

5267 ± 549#

4784 ± 404#

4034 ± 353#

3731 ± 276# $

16

Epac1−/− ND

7208 ± 923

3486 ± 848#

3590 ± 490#

3875 ± 541#

3287 ± 445#

3414 ± 426#

6

Epac1−/− HFD

6522 ± 1226

4393 ± 1251

3916 ± 922

4038 ± 803

3844 ± 789

3377 ± 795

6

Epac2−/− ND

6958 ± 427

5586 ± 1082

5275 ± 865

5850 ± 310

4934 ± 363

6107 ± 275*

6

Epac2−/− HFD

6808 ± 935

4452 ± 617

5198 ± 771

4742 ± 691

4418 ± 629

4262 ± 661

10

  1. # p < 0.05 vs corresponding pre-ischemic stabilization value, * p < 0.05 vs. wt ND, $ p < 0.05 vs. Epac2−/− ND