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Table 2 Hemodynamic parameters

From: Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling

  Group Stab 5’ rep 15’ rep 30’ rep 45’ rep 60’ rep Number
LVDP (mmHg) wt ND 101 ± 7 56 ± 13# 63 ± 7# 56 ± 4# 54 ± 5# 51 ± 4# 8
wt HFD 119 ± 8 94 ± 9# 104 ± 8 95 ± 5* 85 ± 5#,* 74 ± 4# 16
Epac1−/− ND 116 ± 4 72 ± 14# 73 ± 7# 75 ± 8# 77 ± 11# 71 ± 8# 6
Epac1−/− HFD 122 ± 14 89 ± 23# 81 ± 16# 76 ± 15# 82 ± 13# 69 ± 11# 6
Epac2−/− ND 101 ± 8 90 ± 8 92 ± 14 89 ± 12 87 ± 12 88 ± 13 6
Epac2−/− HFD 108 ± 7 81 ± 8 92 ± 12 91 ± 9 80 ± 8 78 ± 9 10
HR (bpm) wt ND 255 ± 22 164 ± 28 173 ± 31 193 ± 29 204 ± 31 208 ± 27 8
wt HFD 260 ± 20 215 ± 24 214 ± 24 196 ± 20$ 195 ± 20 211 ± 24 16
Epac1−/− ND 268 ± 28 269 ± 44 271 ± 42 269 ± 45 272 ± 39 288 ± 39 6
Epac1−/− HFD 288 ± 24 259 ± 57 247 ± 38 254 ± 37 233 ± 43 244 ± 41 6
Epac2−/− ND 300 ± 39 313 ± 41 325 ± 60 338 ± 50 317 ± 51 315 ± 42 6
Epac2−/− HFD 316 ± 29 295 ± 33 280 ± 37 272 ± 27 288 ± 29 286 ± 27 10
dP/dtmin (mmHg/s) wt ND −3926 ± 629 −1287 ± 365# −1549 ± 334# −1511 ± 308# −1642 ± 248# −1954 ± 646# 8
wt HFD −4973 ± 363 −2742 ± 237# −3096 ± 298# −3024 ± 265#* −2804 ± 239# −2501 ± 183# 16
Epac1−/− ND −4342 ± 325 −2378 ± 512# −2408 ± 271# −2464 ± 209# −2458 ± 270# −2457 ± 244# 6
Epac1−/− HFD −4620 ± 691 −2633 ± 664 −2629 ± 553 −2522 ± 632 −2632 ± 539 −2205 ± 464# 6
Epac2−/− ND −4325 ± 159 −3026 ± 342# −2866 ± 298# −3243 ± 260#* −3106 ± 182# −3284 ± 243# 6
Epac2−/− HFD −5031 ± 715 −2997 ± 659# −3352 ± 601* −3074 ± 390#* −3037 ± 381#* −2771 ± 327# 10
dP/dtmax (mmHg/s) wt ND 6327 ± 997 2701 ± 790# 3149 ± 648# 2717 ± 368# 2635 ± 297# 2465 ± 355# 8
wt HFD 7195 ± 846 4632 ± 451# 5267 ± 549# 4784 ± 404# 4034 ± 353# 3731 ± 276# $ 16
Epac1−/− ND 7208 ± 923 3486 ± 848# 3590 ± 490# 3875 ± 541# 3287 ± 445# 3414 ± 426# 6
Epac1−/− HFD 6522 ± 1226 4393 ± 1251 3916 ± 922 4038 ± 803 3844 ± 789 3377 ± 795 6
Epac2−/− ND 6958 ± 427 5586 ± 1082 5275 ± 865 5850 ± 310 4934 ± 363 6107 ± 275* 6
Epac2−/− HFD 6808 ± 935 4452 ± 617 5198 ± 771 4742 ± 691 4418 ± 629 4262 ± 661 10
  1. # p < 0.05 vs corresponding pre-ischemic stabilization value, * p < 0.05 vs. wt ND, $ p < 0.05 vs. Epac2−/− ND
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Nutrition & Metabolism

ISSN: 1743-7075

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