|
Group
|
Stab
|
5’ rep
|
15’ rep
|
30’ rep
|
45’ rep
|
60’ rep
|
Number
|
---|
LVDP (mmHg)
|
wt ND
|
101 ± 7
|
56 ± 13#
|
63 ± 7#
|
56 ± 4#
|
54 ± 5#
|
51 ± 4#
|
8
|
wt HFD
|
119 ± 8
|
94 ± 9#
|
104 ± 8
|
95 ± 5*
|
85 ± 5#,*
|
74 ± 4#
|
16
|
Epac1−/−
ND
|
116 ± 4
|
72 ± 14#
|
73 ± 7#
|
75 ± 8#
|
77 ± 11#
|
71 ± 8#
|
6
|
Epac1−/−
HFD
|
122 ± 14
|
89 ± 23#
|
81 ± 16#
|
76 ± 15#
|
82 ± 13#
|
69 ± 11#
|
6
|
Epac2−/−
ND
|
101 ± 8
|
90 ± 8
|
92 ± 14
|
89 ± 12
|
87 ± 12
|
88 ± 13
|
6
|
Epac2−/−
HFD
|
108 ± 7
|
81 ± 8
|
92 ± 12
|
91 ± 9
|
80 ± 8
|
78 ± 9
|
10
|
HR (bpm)
|
wt ND
|
255 ± 22
|
164 ± 28
|
173 ± 31
|
193 ± 29
|
204 ± 31
|
208 ± 27
|
8
|
wt HFD
|
260 ± 20
|
215 ± 24
|
214 ± 24
|
196 ± 20$
|
195 ± 20
|
211 ± 24
|
16
|
Epac1−/−
ND
|
268 ± 28
|
269 ± 44
|
271 ± 42
|
269 ± 45
|
272 ± 39
|
288 ± 39
|
6
|
Epac1−/−
HFD
|
288 ± 24
|
259 ± 57
|
247 ± 38
|
254 ± 37
|
233 ± 43
|
244 ± 41
|
6
|
Epac2−/−
ND
|
300 ± 39
|
313 ± 41
|
325 ± 60
|
338 ± 50
|
317 ± 51
|
315 ± 42
|
6
|
Epac2−/−
HFD
|
316 ± 29
|
295 ± 33
|
280 ± 37
|
272 ± 27
|
288 ± 29
|
286 ± 27
|
10
|
dP/dtmin (mmHg/s)
|
wt ND
|
−3926 ± 629
|
−1287 ± 365#
|
−1549 ± 334#
|
−1511 ± 308#
|
−1642 ± 248#
|
−1954 ± 646#
|
8
|
wt HFD
|
−4973 ± 363
|
−2742 ± 237#
|
−3096 ± 298#
|
−3024 ± 265#*
|
−2804 ± 239#
|
−2501 ± 183#
|
16
|
Epac1−/−
ND
|
−4342 ± 325
|
−2378 ± 512#
|
−2408 ± 271#
|
−2464 ± 209#
|
−2458 ± 270#
|
−2457 ± 244#
|
6
|
Epac1−/−
HFD
|
−4620 ± 691
|
−2633 ± 664
|
−2629 ± 553
|
−2522 ± 632
|
−2632 ± 539
|
−2205 ± 464#
|
6
|
Epac2−/−
ND
|
−4325 ± 159
|
−3026 ± 342#
|
−2866 ± 298#
|
−3243 ± 260#*
|
−3106 ± 182#
|
−3284 ± 243#
|
6
|
Epac2−/−
HFD
|
−5031 ± 715
|
−2997 ± 659#
|
−3352 ± 601*
|
−3074 ± 390#*
|
−3037 ± 381#*
|
−2771 ± 327#
|
10
|
dP/dtmax (mmHg/s)
|
wt ND
|
6327 ± 997
|
2701 ± 790#
|
3149 ± 648#
|
2717 ± 368#
|
2635 ± 297#
|
2465 ± 355#
|
8
|
wt HFD
|
7195 ± 846
|
4632 ± 451#
|
5267 ± 549#
|
4784 ± 404#
|
4034 ± 353#
|
3731 ± 276#
$
|
16
|
Epac1−/−
ND
|
7208 ± 923
|
3486 ± 848#
|
3590 ± 490#
|
3875 ± 541#
|
3287 ± 445#
|
3414 ± 426#
|
6
|
Epac1−/−
HFD
|
6522 ± 1226
|
4393 ± 1251
|
3916 ± 922
|
4038 ± 803
|
3844 ± 789
|
3377 ± 795
|
6
|
Epac2−/−
ND
|
6958 ± 427
|
5586 ± 1082
|
5275 ± 865
|
5850 ± 310
|
4934 ± 363
|
6107 ± 275*
|
6
|
Epac2−/−
HFD
|
6808 ± 935
|
4452 ± 617
|
5198 ± 771
|
4742 ± 691
|
4418 ± 629
|
4262 ± 661
|
10
|
-
#
p < 0.05 vs corresponding pre-ischemic stabilization value, *
p < 0.05 vs. wt ND, $
p < 0.05 vs. Epac2−/−
ND