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Table 4 Cytokines (pg/mL) at the beginning (V1), after 2 (V2) and 6 weeks (V3) of intervention

From: Evaluation of Lactobacillus coryniformis CECT5711 strain as a coadjuvant in a vaccination process: a randomised clinical trial in healthy adults

 

V1

V2

V3

 

Median

IQR

Median

IQR

Median

IQR

P #

TNF-α

 Control

3.43 a

2.56–4.97

3.83 ab

2.98–4.76

4.03 b

2.80–4.98

0.019

 PRO2

4.20

3.38–5.41

4.63

3.66–5.79

4.07

3.22–6.28

NS

 PRO1

4.23

3.77–5.43

4.35

3.34–5.79

4.60

3.08–6.28

NS

IFN-γ

 Control

6.26 a

2.96–10.75

6.11 b

3.24–12.02

5.97 ab

3.31–12.75

0.049

 PRO2

9.47

2.91–17.46

9.28

4.68–15.94

8.51

5.05–13.77

NS

 PRO1

7.55

3.73–16.36

7.75

4.10–21.40

9.15

4.95–15.72

NS

IL-4

 Control

6.65

3.03–25.23

9.04

2.04–24.57

9.12

2.34–22.38

NS

 PRO2

2.95

0.21–14.60

4.93

0.61–22.78

3.75

1.46–22.42

NS

 PRO1

6.96

1.08–21.74

6.11

1.29–29.09

10.22

2.16–15.38

NS

IL-13

 Control

3.47

0.39–8.46

2.57

0.52–9.57

2.73

1.28–6.18

NS

 PRO2

2.73

0.19–5.44

2.50

0.70–8.77

3.24

0.33–8.55

NS

 PRO1

2.79

0.93–8.50

2.33

0.96–7.21

1.22

0.10–4.73

NS

IL12p70

 Control

3.66

1.22–5.07

4.35

1.85–7.04

4.41

2.41–7.91

NS

 PRO2

5.09

1.40–10.07

5.33

2.72–8.17

4.46

3.03–9.37

NS

 PRO1

5.00

2.67–9.88

4.96

2.17–13.51

5.41

2.79–12.86

NS

IL-10

 Control

21.85 a

11.87–32.52

24.77 ab

16.26–35.42

25.23 b

16.74–42.47

0.030

 PRO2

27.07

13.44–44.61

29.29

19.16–53.47

30.37

19.37–40.75

NS

 PRO1

31.53

20.13–48.29

33.90

16.39–49.96

34.23

16.97–57.00

NS

 IL-6

 Control

1.10

0.46–1.81

1.15

0.57–2.70

1.17

0.56–2.10

NS

 PRO2

2.11

0.76–3.30

2.66

0.63–3.72

1.87

0.68–3.86

NS

 PRO1

1.70

0.79–3.46

1.31

0.79–3.46

1.82

0.97–2.97

NS

  1. Data are expressed as median and interquartile range (IQR. percentile 25-percentil 75). # Differences among visits within each group by Friedman’s test for related samples, also highlighted in bold. Different superscripts mean significant differences between visits (Friedman’s test; P < 0.05)