Table 2 Association of the lipoprotein lipase single nucleotide polymorphisms (SNPs) with HDL-C levels
Association of the SNPs with HDL-C levels (continuous variable) | ||
SNP | HDL-C levels (means ± SD) | |
SNP rs4922115 | ||
 GG | 1.1 ± 0.3 | |
 GA | 1.1 ± 0.2 | |
 AA | 1.1 ± 0.2 | |
Dominant model (GG vs GA + AA) (P value) | 0.02 | |
SNP rs1121923 | ||
 CC | 1.1 ± 0.3 | |
 CT | 1.2 ± 0.3 | |
 TT | 1.0 ± 0.2 | |
Dominant model (CC vs CT + TT) (P value) | 0.02 | |
SNP rs328 | ||
 CC | 1.1 ± 0.3 | |
 CG | 1.2 ± 0.3 | |
 GG | 1.2 ± 0.2 | |
Dominant model (CC vs CG + GG) (P value) | 0.0004 | |
SNP rs285 | ||
 CC | 1.1 ± 0.3 | |
 CT | 1.1 ± 0.2 | |
 TT | 1.2 ± 0.2 | |
Dominant model (CC vs CT + TT) (P value) | 0.03 | |
Association of the SNPs with HDL-C (categorical variable) | ||
| Â | Low HDL-C levels Number (%) | Normal HDL-C levels Number (%) |
SNP rs4922115 | ||
 GG | 366 (65%) | 497 (71.3%) |
 GA | 171 (30.4%) | 167 (25.3%) |
 AA | 26 (4.6%) | 24 (3.4%) |
Dominant model (GG vs GA + AA) (P value) | 0.02 | |
SNP rs1121923 | ||
 CC | 530 (91.7%) | 642 (84.7%) |
 CT | 45 (7.8%) | 112 (14.8%) |
 TT | 3 (0.5%) | 4 (0.5%) |
Dominant model (CC vs CT + TT) (P value) | 0.1 | |
SNP rs328 | ||
 CC | 336 (78.3%) | 540 (69.8%) |
 CG | 88 (20.5%) | 215 (27.8%) |
 GG | 5 (1.2%) | 19 (2.5%) |
Dominant model (CC vs CG + GG) (P value) | 0.001 | |
SNP rs285 | ||
 CC | 336 (45.6%) | 421 (38%) |
 CT | 330 (44.8%) | 515 (46.5%) |
 TT | 71 (9.6%) | 171 (15.4%) |
Dominant model (CC vs CT + TT) (P value) | 0.001 | |