From: Do metabolic syndrome and its components have an impact on bone mineral density in adolescents?
Study | Country | Sample | Design | Outcome measures | Results - association between MetS or risk factors and bone mass |
---|---|---|---|---|---|
Afghani et al. [15] | California/USA | 184 overweight (8 to 13 years) | Cross-sectional | BMC using DXA | Insulin resistance↓ body BMC |
Pollock et al. [16] | Georgia/USA | 140 overweight (7 to 11 years) | Cross-sectional | BMC and BMD using DXA | Pre-diabetes ↓BMC and BMD Hyperinsulinemia ↓BMC and BMD |
Pollock et al. [4] | Georgia/USA | 143 overweight adolescents with cardiometabolic risk factors (14 to 18 years) | Cross-sectional | BMC using DXA | ↑HDL-c ↑BMC ≥2 MetS components ↓BMC Increased WC ↑visceral adipose tissue, fasting insulin and HOMA-IR ↓total body BMC |
Lawlor et al. [5] | United Kingdom | 2035 adolescents (15 years) | Cross-sectional | BMD and BMC using DXA | Hypertriglyceridemia ↑BMD, BMC and in boys Reduced HDL and insulin resistance ↓total body BMD, BMC |
Lee et al. [14] | South Korea | 618 adolescents (10 to 19 years) | Cross-sectional | BMC using DXA | HOMA-IR ↓BMC in boys |
Nóbrega da Silva et al. [7] | Brazil | 270 overweight adolescents (10 to 16 years) | Cross-sectional | BMD using DXA | MetS (+)↓BMD/kg weight lumbar spine, left proximal femur, total and subtotal body Increased WC ↓BMD (lumbar spine and total body) in both genders Hypertriglyceridemia ↓BMD (lumbar spine and total body) in girls. |