TY - JOUR AU - de Paula Simino, Laís Angélica AU - de Fante, Thaís AU - Figueiredo Fontana, Marina AU - Oliveira Borges, Fernanda AU - Torsoni, Márcio Alberto AU - Milanski, Marciane AU - Velloso, Lício Augusto AU - Souza Torsoni, Adriana PY - 2017 DA - 2017/02/20 TI - Lipid overload during gestation and lactation can independently alter lipid homeostasis in offspring and promote metabolic impairment after new challenge to high-fat diet JO - Nutrition & Metabolism SP - 16 VL - 14 IS - 1 AB - Nutritional status in early life is critically involved in the metabolic phenotype of offspring. However the changes triggered by maternal consumption of high-fat diet (HFD) in pre- or postnatal period should be better understood. Here we evaluated whether maternal HFD consumption during gestation and lactation could differently affect liver miR-122 and miR-370 expression leading to metabolic damages observed in offspring. Moreover, we investigate whether early overnutrition program offspring to more harmful response to HFD in later life. SN - 1743-7075 UR - https://doi.org/10.1186/s12986-017-0168-4 DO - 10.1186/s12986-017-0168-4 ID - de Paula Simino2017 ER -